The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
A hierarchical classification of polysaccharide lyases for glycogenomics
Open accessAbstract
Carbohydrate-active enzymes face huge substrate diversity in a highly selective manner using only a limited number of available folds. They are therefore subjected to multiple divergent and convergent evolutionary events. This and their frequent modularity render their functional annotation in genomes difficult in a number of cases. In the present paper, a classification of polysaccharide lyases (the enzymes that cleave polysaccharides using an elimination instead of a hydrolytic mechanism) is shown thoroughly for the first time. Based on the analysis of a large panel of experimentally characterized polysaccharide lyases, we examined the correlation of various enzyme properties with the three levels of the classification: fold, family and subfamily. The resulting hierarchical classification, which should help annotate relevant genes in genomic efforts, is available and constantly updated at the Carbohydrate-Active Enzymes Database (http://www.cazy.org).
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Cited by
The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
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Polysaccharide Utilization Loci: Fueling Microbial Communities
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Metadata
- Authors
- Lombard, V., Bernard, T., Rancurel, C., Brumer, H., Coutinho, P. M., & Henrissat, B.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2010-11-25
- Volume
- 432
- Issue
- 3
- Pages
- 437-444
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1999558053
- Cited by
- 381
- References
- 51
- FWCI
- 17.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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