Tetrahydrobiopterin: biochemistry and pathophysiology

Werner, Ernst R., Blau, Nenad, Thöny, Beat·2011·Biochemical Journal

DOI 10.1042/bj20110293

Cited by (492)

Items 101–200 of 492

Spaceflight-related ocular changes: the potential role of genetics, and the potential of B vitamins as a countermeasure
Smith, Scott M., Zwart, Sara R. · 2018 · Current Opinion in Clinical Nutrition & Metabolic Care
Tetrahydrobiopterin as a rheostat of cell resistance to oxidant injury
R Steven Traeger, James Woodcock, Sidhartha Tan, Zhongjie Shi, Jeannette M. Vasquez-Vivar · 2024 · Redox Biology
Analysis of Catecholamines and Pterins in Inborn Errors of Monoamine Neurotransmitter Metabolism—From Past to Future
Sabine Jung‐Klawitter, Oya Kuseyri Hübschmann · 2019 · Cells
Tetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy
Jeannette M. Vasquez-Vivar, Zhongjie Shi, Kehuan Luo, Karthikeyan Thirugnanam, Sidhartha Tan · 2017 · Redox Biology
Epigenetic regulation of melatonin receptors in neuropsychiatric disorders
Sarra G. Bahna, Lennard P. Niles · 2017 · British Journal of Pharmacology
Markers of Inflammation and Monoamine Metabolism Indicate Accelerated Aging in Bipolar Disorder
Seline van den Ameele, Dietmar Fuchs, Violette Coppens, Peter de Boer, Maarten Timmers, Bernard Sabbe, Manuel Morrens · 2018 · Frontiers in Psychiatry
Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain Hypersensitivity
Ananda Staats Pires, Vanessa X. Tan, Benjamin Heng, Gilles J. Guillemin, Alexandra Latini · 2020 · Frontiers in Neuroscience
Ferroptosis: Emerging Role in Diseases and Potential Implication of Bioactive Compounds
Giuseppe Tancredi Patanè, Stefano Putaggio, Ester Tellone, Davide Barreca, Silvana Ficarra, Carlo Maffei, Antonella Calderaro, Giuseppina Laganà · 2023 · International Journal of Molecular Sciences
The Genetics of Dystonias
Mark S. LeDoux · 2012 · Advances in genetics
Cuticle Integrity and Biogenic Amine Synthesis in Caenorhabditis elegans Require the Cofactor Tetrahydrobiopterin (BH4)
Curtis M. Loer, Ana C Calvo, Katrin Watschinger, Gabriele Werner‐Felmayer, Delia O’Rourke, Dave Stroud, Amy Tong, Jennifer R Gotenstein, Andrew D. Chisholm, Jonathan Hodgkin et al. · 2015 · Genetics
Larval but not adult xanthophore pigmentation in zebrafish requires GTP cyclohydrolase 2 ( gch2 ) function
Lister, James A. · 2019 · Pigment Cell & Melanoma Research
Role of aromatic amino acids in pathogeneses of diabetic nephropathy in Chinese patients with type 2 diabetes
Zhang Shiti, Xin Li, Huihuan Luo, Zhong‐Ze Fang, Hao Ai · 2020 · Journal of Diabetes and its Complications
The neurobiology of tetrahydrobiopterin biosynthesis: A model for regulation of GTP cyclohydrolase I gene transcription within nigrostriatal dopamine neurons
Gregory Kapatos · 2013 · IUBMB Life
The role of ferroptosis in metabolic diseases
Ling Xie, Bin Fang, Chun Zhang · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Sepiapterin reductase promotes hepatocellular carcinoma progression via FoxO3a/Bim signaling in a nonenzymatic manner
Yao Wu, Hongzhi Du, Meixiao Zhan, Hongxv Wang, Peng Chen, Danyu Du, Xinyi Liu, Xingxv Huang, Pengcheng Ma, Dezheng Peng et al. · 2020 · Cell Death and Disease
Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite
Matthew R. Dent, Anthony W. DeMartino, Jesús Tejero, Mark T. Gladwin · 2021 · Inorganic Chemistry
RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays
Robyn T. Rebbeck, Daniel P. Singh, Kevyn A. Janicek, Donald M. Bers, David Dale Thomas, Bradley S. Launikonis, Rǎzvan L. Cornea · 2020 · Scientific Reports
Melanin and Neuromelanin: Linking Skin Pigmentation and Parkinson's Disease
Talia Krainc, Mariana H.G. Monje, Morgan Kinsinger, Bernabé I. Bustos, Steven J Lubbe · 2022 · Movement Disorders
Disturbed Serotonergic Neurotransmission and Oxidative Stress in Elderly Patients with Delirium
Angelique Egberts, Durk Fekkes, Eline H.A. Wijnbeld, Milly A. van der Ploeg, Jan L.C.M. van Saase, Gijsbertus J. Ziere, Tischa J. M. van der Cammen, Francesco U.S. Mattace-Raso · 2015 · Dementia and Geriatric Cognitive Disorders Extra
Upregulation of AUF1 is involved in the proliferation of esophageal squamous cell carcinoma through GCH1
Yi Gao, Wenjie Wang, Jinming Cao, Fangjun Wang, Yangyang Geng, Jianping Cao, Xiaohui Xu, Jundong Zhou, Pengfei Liu, Shuyu Zhang · 2016 · International Journal of Oncology
RETRACTED: Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo
Mario Vaccaro, Natasha Irrera, Giuseppina Cutroneo, Giuseppina Rizzo, Federico Vaccaro, Giuseppe Anastasi, Francesco Borgia, Serafinella Patrizia Cannavò, Domenica Altavilla, Francesco Squadrito · 2017 · International Journal of Molecular Sciences · Retracted
Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling
Katja Zschiebsch, Caroline Fischer, Geethanjali Pickert, Annett Häußler, Heinfried H. Radeke, Sabine Grösch, Nerea Ferreirós, Gerd Geißlinger, Ernst R. Werner, Irmgard Tegeder · 2016 · Journal of Crohn s and Colitis
Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis
Daniele Cavaleri, Francesco Bartoli, Chiara Alessandra Capogrosso, Pierluca Guzzi, Federico Moretti, Ilaria Riboldi, Błażej Misiak, Taro Kishi, Robert T. Rubín, Dietmar Fuchs et al. · 2022 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain
Daigo Homma, Setsuko Katoh, Hirofumi Tokuoka, Hiroshi Ichinose · 2013 · Journal of Neurochemistry
Dynamic Regulation of Phenylalanine Hydroxylase by Simulated Redox Manipulation
Julian E. Fuchs, Roland G. Huber, Susanne von Grafenstein, Hannes G. Wallnoefer, Gudrun Maria Spitzer, Dietmar Fuchs, Klaus Roman Liedl · 2012 · PLoS ONE
The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification
S. Sailer, Markus Andreas Keller, Ernst R. Werner, Katrin Watschinger · 2021 · Life
Simultaneous quantification of tetrahydrobiopterin, dihydrobiopterin, and biopterin by liquid chromatography coupled electrospray tandem mass spectrometry
Lise Fismen, Torunn Eide, Rune Djurhuus, Asbjørn M. Svardal · 2012 · Analytical Biochemistry
Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy
M. Silva, Daniel Martins, Ana Charrua, Fabiana Piscitelli, Isaura Tavares, C. Morgado, Vincenzo Di Marzo · 2016 · Neuropharmacology
Moderate running exercise prevents excessive immune system activation
Débora da Luz Scheffer, Karina Ghisoni, Aderbal S. Aguiar, Alexandra Latini · 2019 · Physiology & Behavior
Sepiapterin reductase: Characteristics and role in diseases
Yao Wu, Peng Chen, Li Sun, Shengtao Yuan, Zujue Cheng, Ligong Lu, Hongzhi Du, Meixiao Zhan · 2020 · Journal of Cellular and Molecular Medicine
Elevated Levels of Plasma Phenylalanine in Schizophrenia: A Guanosine Triphosphate Cyclohydrolase-1 Metabolic Pathway Abnormality?
Olaoluwa O. Okusaga, Olesja Muravitskaja, Dietmar Fuchs, Ayesha Ashraf, Sarah J. Hinman, Ina Giegling, Annette M. Hartmann, Bettina Konte, Marion Friedl, Jason Eric Schiffman et al. · 2014 · PLoS ONE
Urine sepiapterin excretion as a new diagnostic marker for sepiapterin reductase deficiency
Claudia Carducci, Silvia Santagata, Jennifer Friedman, Elisabetta Pasquini, Carla Carducci, Manuela Tolve, Antonio Angeloni, Vincenzo Leuzzi · 2015 · Molecular Genetics and Metabolism
The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase
Oscar Aubi, Karina S. Prestegård, Kunwar Jung‐KC, Tie-Jun Sten Shi, Ming Ying, Ann Kari Grindheim, Tanja Scherer, Arve Ulvik, Adrian McCann, Endy Spriet et al. · 2021 · Nature Communications
Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line
Diana Balasubramanian, Alicia X. Deng, Kit Doudney, Mark B. Hampton, Martin Alexander Kennedy · 2015 · Neuropharmacology
Pseudoexon exclusion by antisense therapy in 6-pyruvoyl-tetrahydropterin synthase deficiency
Sandra Brasil, Hiu Man Viecelli, David Meili, Anahita Rassi, Lourdes R. Desviat, Belen Pérez, Magdalena Ugarte, Beat Thöny · 2011 · Human Mutation
Novel Interaction of Ornithine Decarboxylase with Sepiapterin Reductase Regulates Neuroblastoma Cell Proliferation
Ingo Lange, Dirk Geerts, David J. Feith, Gábor Mócz, Jan Köster, André S. Bachmann · 2013 · Journal of Molecular Biology
Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice
Anish Engineer, Tana Saiyin, Xiangru Lu, Andrew Stanton Kucey, Bradley L. Urquhart, Thomas A. Drysdale, Kambiz Norozi, Qingping Feng · 2018 · Journal of the American Heart Association
Mutation spectrum of hyperphenylalaninemia candidate genes and the genotype-phenotype correlation in the Chinese population
Ruifang Wang, Nan Shen, Jun Ye, Lianshu Han, Wenjuan Qiu, Huiwen Zhang, Lili Liang, Yu Sun, Yanjie Fan, Lili Wang et al. · 2018 · Clinica Chimica Acta
Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis
Jia Zhou, Lingna Xu, Xiuying Duan, Wei Liu, Xiaocui Zhao, Xi Wang, Weina Shang, Xuefei Fang, Huan Yang, Lijun Jia et al. · 2019 · Science Advances
Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy
Hsiang-En Wu, Shelley L. Baumgardt, Juan Fang, Mark R. Paterson, Yanan Liu, Jianhai Du, Yang Shi, Shigang Qiao, Zeljko J. Bosnjak, David C. Warltier et al. · 2016 · Scientific Reports
Sulfa Drugs Inhibit Sepiapterin Reduction and Chemical Redox Cycling by Sepiapterin Reductase
Shaojun Yang, Yi-Hua Jan, Vladimir M. Mishin, Jason R. Richardson, Muhammad M. Hossain, Ned D. Heindel, Diane E. Heck, Debra L. Laskin, Jeffrey D. Laskin · 2014 · Journal of Pharmacology and Experimental Therapeutics
Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice
Jaques Belik, Yulia Shifrin, Erland Arning, Teodoro Bottiglieri, Jingyi Pan, Michelle C. Daigneault, Emma Allen‐Vercoe · 2017 · Scientific Reports
Rapid Atrial Pacing Promotes Atrial Fibrillation Substrate in Unanesthetized Instrumented Rats
Wesam Mulla, Barak Hajaj, Sigal Elyagon, Michal Mor, Roni Gillis, Michael Murninkas, Hadar Klapper‐Goldstein, Inbar Plaschkes, Vered Chalifa Caspi, Sharon Etzion et al. · 2019 · Frontiers in Physiology
Genetic susceptibility to diabetic kidney disease is linked to promoter variants of XOR
Qin Wang, Haiying Qi, Yiming Wu, Liping Yu, Rihab Bouchareb, Shuyu Li, Emelie Lassén, Gabriella Casalena, Krisztián Stadler, Kerstin Ebefors et al. · 2023 · Nature Metabolism
Biochemical and Structural Studies of 6-Carboxy-5,6,7,8-tetrahydropterin Synthase Reveal the Molecular Basis of Catalytic Promiscuity within the Tunnel-fold Superfamily
Zachary D. Miles, Sue A. Roberts, Reid M. McCarty, Vahe Bandarian · 2014 · Journal of Biological Chemistry
Determination of Pteridines in Biological Samples with an Emphasis on Their Stability
Helena Tomšíková, Pavel Tomšík, Petr Solich, Lucie Nováková · 2013 · Bioanalysis
Fast clinical molecular diagnosis of hyperphenylalaninemia using next-generation sequencing-based on a custom AmpliSeq™ panel and Ion Torrent PGM sequencing
Yanyan Cao, Yu-jin Qu, Fang Song, Ting Zhang, Jinli Bai, Yu-wei Jin, Hong Wang · 2014 · Molecular Genetics and Metabolism
Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo
Alan Mortensen, Stine Hasselholt, Pernille Tveden‐Nyborg, Jens Lykkesfeldt · 2013 · Nutrition Research
A fat-derived metabolite regulates a peptidergic feeding circuit in Drosophila
Do‐Hyoung Kim, Minjung Shin, Sunghwan Jung, Young‐Joon Kim, Walton D. Jones · 2017 · PLoS Biology
Broadening horizons: the multifaceted role of ferroptosis in breast cancer
Anqi Ge, Xiang Wang, Yan Li, Zhao Da, Junpeng Chen, Pawan Daga, Charles C. Dai, Kailin Yang, Yexing Yan, Moujia Hao et al. · 2024 · Frontiers in Immunology
GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases
Parul Gupta, Ravindra Kumar · 2023 · Gene
Clinical and genetic studies in a family with a novel mutation in the sepiapterin reductase gene
Jeanette Aimee Koht, Aina Haugen Rengmark, Thomas Opladen, Kari Anne Bjørnarå, Terje Reidar Selberg, Chantal M E Tallaksen, Nenad Blau, Mathias Toft · 2014 · Acta Neurologica Scandinavica
Sepiapterin Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells
Shaojun Yang, Yi-Hua Jan, Joshua P. Gray, Vladimir M. Mishin, Diane E. Heck, Debra L. Laskin, Jeffrey D. Laskin · 2013 · Journal of Biological Chemistry
Tetrahydrobiopterin Improves Recognition Memory in the Triple-Transgenic Mouse Model of Alzheimer’s Disease, Without Altering Amyloid-β and Tau Pathologies
Hortense Fanet, Marine Tournissac, Manon Leclerc, Vicky Caron, Cyntia Tremblay, Sylvie Vancassel, Frédéric Calon · 2020 · Journal of Alzheimer s Disease
Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications
Zhili Wu, Yanru Zhu, Wen‐Chao Liu, Balamuralikrishnan Balasubramanian, Xiao Lin Xu, Junhu Yao, X. J. Lei · 2024 · Antioxidants
Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling
Kurt Schmidt, Bernd Kolesnik, Antonius C.F. Gorren, Ernst R. Werner, Bernd Mayer · 2014 · Biochemical Pharmacology
Tryptophan hydroxylase and serotonin synthesis regulation
Donald M. Kuhn, H. Hasegawa · 2020 · Handbook of Behavioral Neuroscience
Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure
Krzysztof Milewski, Anna Maria Czarnecka, Jan Albrecht, Magdalena Zielińska · 2021 · International Journal of Molecular Sciences
Differences in the sperm metabolomes of smoking and nonsmoking men
Kathrin M. Engel, Sven Baumann, Janet Blaurock, Ulrike Elisabeth Rolle-Kampczyk, Jürgen Schiller, Martin von Bergen�, Sonja Grunewald · 2021 · Biology of Reproduction
Mast cell–derived BH4 and serotonin are critical mediators of postoperative pain
Philipp M. Starkl, Gustav Jonsson, Tyler Artner, Bruna Lenfers Turnes, Laura Marie Gail, Tiago Oliveira, Aakanksha Jain, Nadine Serhan, Karel Stejskal, Karin Lakovits et al. · 2024 · Science Immunology
The recent advancements of ferroptosis of gynecological cancer
Shenglan Tang, Li Chen · 2024 · Cancer Cell International
Tetrahydrobiopterin Improves Endothelial Function in Cardiovascular Disease: A Systematic Review
Qiongying Wang, Mina Yang, Xu Han, Jing Yu · 2014 · Evidence-based Complementary and Alternative Medicine
The alkylglycerol monooxygenase (AGMO) gene previously involved in autism also causes a novel syndromic form of primary microcephaly in a consanguineous Saudi family
Nuha Mohammad Alrayes, Hussein Sheikh Ali Mohamoud, Saleem Ahmed, Mona Mohammad Almramhi, Taghreed Shuaib, Jun Wang, Jumana Yousuf Al-Aama, Kate V. Everett, Jamal Nasir, Musharraf Jelani · 2016 · Journal of the Neurological Sciences
BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes
Ricardo Carnicer, Drew Duglan, Klemen Žiberna, Alice Récalde, Svetlana N. Reilly, Jillian N. Simon, Simona Fortunata Mafrici, Ritu Arya, Esther Roselló‐Lletí, Surawee Chuaiphichai et al. · 2021 · Circulation Research
Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway
Benjamin J. R. Moore, Barira Islam, Sean Ward, Olivia Jackson, Rebecca Armitage, Jack Blackburn, Shozeb M Haider, Patrick McHugh · 2019 · ACS Omega
Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice
Catherine M. Sampson, Andrea Dimet‐Wiley, Harshini Neelakantan, Kehinde O. Ogunseye, Heather L. Stevenson, Jonathan D. Hommel, Stanley J. Watowich · 2021 · Scientific Reports
Anxiety- and depression-like phenotype of hph-1 mice deficient in tetrahydrobiopterin
Arafat Nasser, Lisbeth Birk Møller, Jess Have Olesen, Louise S Konradsen, Jesper Tobias Andreasen · 2014 · Neuroscience Research
Imbalance between nitric oxide and superoxide anion induced by uncoupled nitric oxide synthase contributes to human melanoma development
Diego Assis Gonçalves, Ricardo Xisto de Sousa, Jéssica Domingues Gonçalves, Douglas Baceti Silva, Jaqueline Pereira Moura Soares, Marcelo Yudi Icimoto, Carla Sant Anna Correa, Marcela Gimenez, Kátia De Angelis, Susana Llesuy et al. · 2019 · The International Journal of Biochemistry & Cell Biology
Nitric oxide: A potential etiological agent for vaso-occlusive crises in sickle cell disease
Parul Gupta, Ravindra Kumar · 2024 · Nitric Oxide
Pet-1 Controls Tetrahydrobiopterin Pathway andSlc22a3Transporter Genes in Serotonin Neurons
Steven C. Wyler, Lauren J. Donovan, Mia Yeager, Evan S. Deneris · 2015 · ACS Chemical Neuroscience
Evaluation of dietary intake in children and college students with and without attention-deficit/hyperactivity disorder
Kathleen F. Holton, Jeanette M. Johnstone, Elizabeth T. Brandley, Joel T. Nigg · 2018 · Nutritional Neuroscience
Tetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice
Hortense Fanet, Fabien Ducrocq, Marine Tournissac, Asma Oummadi, A. Lô, Philippe Bourassa, Véronique De Smedt, B. Azzougen, Lucile Capuron, Sophie Layé et al. · 2019 · Behavioural Brain Research
GCH1 variants, tetrahydrobiopterin and their effects on pain sensitivity
Arafat Nasser, Lisbeth Birk Møller · 2014 · Scandinavian Journal of Pain
Genetics of Magnesium Disorders
Heng Li, Shiren Sun, Jianghua Chen, Goushuang Xu, Hanmin Wang, Qi Qian · 2017 · Kidney Diseases
Tetrahydrobiopterin modulates the behavioral neuroinflammatory response to an LPS challenge in mice
Sylvie Vancassel, Hortense Fanet, Nathalie Castanon, Camille Monchaux de Oliveira, Sofia Cussotto, Lucile Capuron · 2022 · Brain Behavior and Immunity
Tetrahydrobiopterin Protects Soluble Guanylate Cyclase against Oxidative Inactivation
Kurt Schmidt, Andrea Neubauer, Bernd Kolesnik, Johannes‐Peter Stasch, Ernst R. Werner, Antonius C.F. Gorren, Bernd Mayer · 2012 · Molecular Pharmacology
The interplay between aryl hydrocarbon receptor, H. pylori, tryptophan, and arginine in the pathogenesis of gastric cancer
Marzieh Pirzadeh, Nastaran Khalili, Nima Rezaei · 2020 · International Reviews of Immunology
Biosynthesis of Pteridines in Insects: A Review
Juan Ferré · 2024 · Insects
Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson’s disease patients
Débora da Luz Scheffer, Fernando Cini Freitas, Aderbal S. Aguiar, Catherine Ward, Luiz Guilherme Antonacci Guglielmo, Rui Daniel Prediger, Shane J. F. Cronin, Roger Walz, Nick A Andrews, Alexandra Latini · 2021 · Brain Communications
Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth
Liye Chen, Xin Zeng, Esther A. Kleibeuker, Francesca Meteora Buffa, Alessandro Barberis, Russell Leek, Ioannis Roxanis, Wei Zhang, Andrew T. Worth, John S. Beech et al. · 2016 · Oncotarget
Tetrahydrobiopterin improves hippocampal nitric oxide-linked long-term memory
Alexandra Latini, Lucila de Bortoli da Silva, Débora da Luz Scheffer, Ananda Staats Pires, Filipe Matos, Renata Tiscoski Nesi, Karina Ghisoni, Roberta de Paula Martins, Paulo Alexandre de Oliveira, Rui Daniel Prediger et al. · 2018 · Molecular Genetics and Metabolism
Mitochondrial NAD(P)+ Transhydrogenase is Unevenly Distributed in Different Brain Regions, and its Loss Causes Depressive-like Behavior and Motor Dysfunction in Mice
Annelise Francisco, Daiane Fátima Engel, Tiago R. Figueira, Fábio Rogério, Andreza Fabro De Bem, Roger Frigerio Castilho · 2020 · Neuroscience
Multiple Shades of Gray—Macrophages in Acute Allograft Rejection
Katharina Lackner, Susanne Ebner, Katrin Watschinger, Manuel Maglione · 2023 · International Journal of Molecular Sciences
Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism
Yasuo Oguri, Yoshihito Fujita, Abudukadier Abulizi, Akiko Ohashi, Tsuyoshi Goto, Futoshi Furuya, Akio Obara, Toru Fukushima, Naomi Matsuo, Minji Kim et al. · 2017 · JCI Insight
Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice
Masahide Fujita, Débora da Luz Scheffer, Bruna Lenfers Turnes, Shane J. F. Cronin, Alban Latrémolière, Michael Costigan, Clifford J. Woolf, Alexandra Latini, Nick A. Andrews · 2019 · Arthritis & Rheumatology
Tetrahydrobiopterin reverse left ventricular hypertrophy and diastolic dysfunction through the PI3K/p-Akt pathway in spontaneously hypertensive rats
Peng Chang, Qiongying Wang, Xu Han, Mina Yang, Xin Lin, Xiuli Li, Zhengyi Zhang, Xiaowei Zhang, Feng Zhao, Xu Zhao et al. · 2015 · Biochemical and Biophysical Research Communications
Epigenetic modifications induced by exercise: Drug-free intervention to improve cognitive deficits associated with obesity
Leonardo Barros, Tuany Eichwald, Alexandre Francisco Solano, Débora da Luz Scheffer, Rodrigo A. da Silva, Joana Margarida Gaspar, Alexandra Latini · 2019 · Physiology & Behavior
Factors influencing the soluble guanylate cyclase heme redox state in blood vessels
Masashi Tawa, Tomio Okamura · 2022 · Vascular Pharmacology
DNAJC12 in Monoamine Metabolism, Neurodevelopment, and Neurodegeneration
Isaac Bul Deng, Jordan Follett, Mengfei Bu, Matthew James Farrer · 2023 · Movement Disorders
Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase
Katrin Watschinger, Julian E. Fuchs, Vladimir M. Yarov-Yarovoy, Markus Andreas Keller, Georg Golderer, Albin Hermetter, Gabriele Werner‐Felmayer, Nicolas Hulo, Ernst R. Werner · 2012 · Biochemical Journal
Diagnosis, treatment and follow-up of patients with tetrahydrobiopterin deficiency in Shandong province, China
Bingjuan Han, Hui Zou, Bingchao Han, Weiwei Zhu, Zhiyang Cao, Yingxia Liu · 2014 · Brain and Development
Combining Human and Rodent Genetics to Identify New Analgesics
Alban Latrémolière, Michael Costigan · 2017 · Neuroscience Bulletin
Peripheral biopterin and neopterin in schizophrenia and depression
Federica Klaus, Karoline Guetter, Rebecca Schlegel, Erich Seifritz, Anahita Rassi, Beat Thöny, Flurin Cathomas, Stefan Kaiser · 2021 · Psychiatry Research
Neonatal screening and genotype-phenotype correlation of hyperphenylalaninemia in the Chinese population
Xin Wang, Yanyun Wang, Dingyuan Ma, Zhilei Zhang, Yahong Li, Peiying Yang, Yun Sun, Tao Jiang · 2021 · Orphanet Journal of Rare Diseases
Moderation of the relationship between Toxoplasma gondii seropositivity and trait impulsivity in younger men by the phenylalanine-tyrosine ratio
Peng, Xiaoqing, Brenner, Lisa A., Mathai, Ashwin J., Cook, Thomas B., Fuchs, Dietmar, Postolache, Nadine, Groer, Maureen W., Pandey, Janardan P., Mohyuddin, Farooq, Giegling, Ina et al. · 2018 · Psychiatry Research
Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation
Hui Chen, Lingli Chen, Wenjun Wang · 2023 · Food Science and Human Wellness
Disruption of tetrahydrobiopterin (BH4) biosynthesis pathway affects cuticle pigmentation in Henosepilachna vigintioctopunctata
Long‐Ji Ze, Ping Xu, Jian‐Jian Wu, Lin Jin, Ahmad Ali Anjum, Guo‐Qing Li · 2022 · Journal of Insect Physiology
Endogenous chemicals guard health through inhibiting ferroptotic cell death
Yuan‐Hao Song, Hong-Xu Lei, Yu Dou, Hao Zhu, Meng‐Zhu Hao, Rong‐Hua Cui, Xiang‐Shuai Meng, X. D. Sheng, Lei Zhang · 2023 · BioFactors
Dopamine‑iron homeostasis interaction rescues mitochondrial fitness in Parkinson's disease
Chiara Buoso, Markus Seifert, Martin Lang, Corey M. Griffith, Begoña Talavera Andújar, Maria Paulina Castelo Rueda, Christine Fischer, Carolina Doerrier, Heribert Talasz, Alessandra Zanon et al. · 2024 · Neurobiology of Disease
A novel GTPCH deficiency mouse model exhibiting tetrahydrobiopterin-related metabolic disturbance and infancy-onset motor impairments
Xiaoling Jiang, Huazhen Liu, Yongxian Shao, Mingzhi Peng, Wen Zhang, Duan Li, Xiuzhen Li, Yanna Cai, Ting Tan, Xinshuo Lu et al. · 2019 · Metabolism