Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
Magnuson, Brian, Ekim, Bilgen, Fingar, Diane C.·2012·Biochemical Journal
Cites (241)
Items 201–237 of 237
- Mice Deficient in Ribosomal Protein S6 Phosphorylation Suffer from Muscle Weakness that Reflects a Growth Defect and Energy DeficitIgor Ruvinsky, Maximiliano J. Katz, Avigail Dreazen, Yuval Gielchinsky, Ann Saada, Nanette Freedman, Eyal Mishani, Gabriel Zimmerman, Judith Kasir, Oded Meyuhas · 2009 · PLoS ONE
- Dual Requirement for a Newly Identified Phosphorylation Site in p70 s6kBettina A. Moser, Patrick B. Dennis, Nick Pullen, Richard B. Pearson, Nicholas A. Williamson, Richard E.H. Wettenhall, Sara C. Kozma, George Thomas · 1997 · Molecular and Cellular Biology
- Cdc42 Stimulates RNA Splicing via the S6 Kinase and a Novel S6 Kinase Target, the Nuclear Cap-binding Complex*Kristin F. Wilson, Wen-Jin Wu, R. Cerione · 2000 · Journal of Biological Chemistry
- p90 Ribosomal S6 Kinase and p70 Ribosomal S6 Kinase Link Phosphorylation of the Eukaryotic Chaperonin Containing TCP-1 to Growth Factor, Insulin, and Nutrient SignalingYuki Abe, Sang-Oh Yoon, Kazuishi Kubota, Michelle C. Mendoza, Steven P. Gygi, John Blenis · 2009 · Journal of Biological Chemistry
- S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy.Jian-Kang Chen, Jian-Chun Chen, G. Thomas, S. Kozma, Raymond C. Harris · 2009 · AJP - Renal Physiology
- Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); A novel nuclear target of AktHyongjong Koh, Kwangho Jee, Bona Lee, Jeong‐Hoon Kim, Dohoon Kim, Young-Ha Yun, Jung Woo Kim, Heung-Sik Choi, Jongkyeong Chung · 1999 · Oncogene
- mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic MotifYoutong Wu, Weiming Ouyang, Adam S. Lazorchak, Dou Liu, Han‐Ming Shen, Bing Su · 2011 · Journal of Biological Chemistry
- Characterization of Phosphatidylinositol 3-Kinase-dependent Phosphorylation of the Hydrophobic Motif Site Thr389 in p70 S6 Kinase 1Angela Romanelli, Valley C. Dreisbach, John Blenis · 2002 · Journal of Biological Chemistry
- Differential Involvement of IκB Kinases α and β in Cytokine- and Insulin-Induced Mammalian Target of Rapamycin Activation Determined by AktHan C. Dan, Albert S. Baldwin · 2008 · The Journal of Immunology
- IKKβ suppression of TSC1 function links the mTOR pathway with insulin resistanceHung · 1998 · International Journal of Molecular Medicine
- The Role of Phosphatases in TOR Signaling in YeastKatrin Düvel, James Riley Broach · 2004 · Current topics in microbiology and immunology
- Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation*Kathleen A. Martin, S. Schalm, A. Romanelli, Kristen L. Keon, J. Blenis · 2001 · Journal of Biological Chemistry
- Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway*K. Martin, S. Schalm, C. Richardson, A. Romanelli, Kristen L. Keon, J. Blenis · 2001 · Journal of Biological Chemistry
- Protein Kinase C Phosphorylates Ribosomal Protein S6 Kinase βII and Regulates Its Subcellular LocalizationTaras Valovka, Frédèrique Verdier, Rainer Cramer, Alexander Zhyvoloup, Tim R. Fenton, Heike Rebholz, Mong‐Lien Wang, M. R. Gzhegotsky, Alexander D. Lutsyk, G. Kh. Matsuka et al. · 2003 · Molecular and Cellular Biology
- mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3‐L1 AdipocytesGhada A. Soliman, Hugo A. Acosta-Jaquez, Diane C. Fingar · 2010 · Lipids
- Regulation of Mammalian Target of Rapamycin Activity in PTEN-Inactive Prostate Cancer Cells by IκB Kinase αHan C. Dan, Mazhar Adli, Albert S. Baldwin · 2007 · Cancer Research
- Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2Delphine R. Boulbés, Chien-Hung Chen, Tattym E. Shaiken, Nitin Agarwal, Timothy R. Peterson, Terri A. Addona, Hasmik Keshishian, Steven A. Carr, Mark A. Magnuson, David M. Sabatini et al. · 2010 · Molecular Cancer Research
- Involvement of Heterogeneous Ribonucleoprotein F in the Regulation of Cell Proliferation via the Mammalian Target of Rapamycin/S6 Kinase 2 PathwayEddy T. H. Goh, Olivier E. Pardo, Nicholas Michael, Andrew Niewiarowski, Nick Totty, Dariya Volkova, Irina R. Tsaneva, Michael J. Seckl, Ivan T. Gout · 2010 · Journal of Biological Chemistry
- Regulation of protein synthesis and the role of eIF3 in cancerJohn W.B. Hershey · 2010 · Brazilian Journal of Medical and Biological Research
- Characterization of a Conserved C-terminal Motif (RSPRR) in Ribosomal Protein S6 Kinase 1 Required for Its Mammalian Target of Rapamycin-dependent RegulationStefanie S. Schalm, Andrew R. Tee, John Blenis · 2005 · Journal of Biological Chemistry
- Insulin-activated protein kinases phosphorylate a pseudosubstrate synthetic peptide inhibitor of the p70 S6 kinase.Daniel J. Price, Nishit K. Mukhopadhyay, Joseph Avruch · 1991 · Journal of Biological Chemistry
- Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop PhosphorylationT. Sunami, Noel J. Byrne, Ronald E. Diehl, Kaoru Funabashi, Dawn L. Hall, Mari Ikuta, Sangita B. Patel, Jennifer M. Shipman, Robert Frank Smith, Ikuko Takahashi et al. · 2009 · Journal of Biological Chemistry
- Cloning and Expression of Two Human p70 S6 Kinase Polypeptides Differing Only at Their Amino TerminiJ. Russell Grove, Papia T. Banerjee, Ashok Balasubramanyam · 1991 · Molecular and Cellular Biology
- Cloning and Characterization of p70S6KβDefines a Novel Family of p70 S6 KinasesM. Saitoh, P. ten Dijke, K. Miyazono, H. Ichijo · 1998 · Biochemical and Biophysical Research Communications
- Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)Malik M. Keshwani, Sventja von Daake, Alexandra C. Newton, Thomas K. Harris, Susan Serota Taylor · 2011 · Journal of Biological Chemistry
- Regulation and localization of ribosomal protein S6 kinase 1 isoformsDoyil Kim, Argun Akçakanat, Gopal Singh, Chandeshwar Sharma, Funda Meric‐Bernstam · 2008 · Growth Factors
- Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivoTim R. Fenton, Jodie Gwalter, Johan Ericsson, Ivan T. Gout · 2009 · The International Journal of Biochemistry & Cell Biology
- Regulation of ribosomal protein S6 kinases by ubiquitinationMong‐Lien Wang, Ganna Panasyuk, Jodie Gwalter, Ivan Nemazanyy, Tim R. Fenton, Valeriy V Filonenko, Ivan T. Gout · 2008 · Biochemical and Biophysical Research Communications
- Identification of S6K2 as a centrosome‐located kinaseRossella Rossi, John M. Pester, M.D. McDowell, Samuela Soza, Alessandra Montecucco, Kay K. Lee-Fruman · 2007 · FEBS Letters
- Regulation of catalytic activity of S6 kinase 2 during cell cycleDerek Boyer, Rene Harold Quintanilla, Kay K. Lee-Fruman · 2007 · Molecular and Cellular Biochemistry
- p70 Ribosomal S6 Kinase Is Required for Airway Smooth Muscle Cell Size Enlargement but Not Increased Contractile Protein ExpressionHuan Deng, Marc B. Hershenson, Jing Lei, Khalil N. Bitar, Diane C. Fingar, Julian Solway, John Kelley Bentley · 2009 · American Journal of Respiratory Cell and Molecular Biology
- S6 kinase 2 potentiates interleukin-3-driven cell proliferationRebecca Cruz, Lee Hedden, Derek Boyer, Michael G. Kharas, David A Fruman, Kay K. Lee-Fruman · 2005 · Journal of Leukocyte Biology
- Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1Sopheap Phin, Deborah Kupferwasser, Joseph LAM, Kay K. Lee-Fruman · 2003 · Biochemical Journal
- Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1Ganna Panasyuk, Ivan Nemazanyy, Valeriy V Filonenko, Ivan T. Gout · 2008 · Biochemical and Biophysical Research Communications
- Differential Expression of S6K2 Dictates Tissue-Specific Requirement for S6K1 in Mediating Aberrant mTORC1 Signaling and TumorigenesisCaterina Nardella, Andrea Lunardi, Giuseppe Fedele, John G. Clohessy, Andrea Alimonti, Sara C. Kozma, George Thomas, Massimo F. Loda, Pier Paolo Pandolfi · 2011 · Cancer Research
- S6K1 is acetylated at lysine 516 in response to growth factor stimulationTim R. Fenton, Jodie Gwalter, Rainer Cramer, Ivan T. Gout · 2010 · Biochemical and Biophysical Research Communications
- The ubiquitination of ribosomal S6 kinases is independent from the mitogen-induced phosphorylation/activation of the kinaseJodie Gwalter, M.-L. Wang, Ivan T. Gout · 2008 · The International Journal of Biochemistry & Cell Biology