Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
Abstract
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely defined roles in cellular and organismal physiology. TORC1 functions as an environmental sensor by integrating signals derived from diverse environmental cues to promote anabolic and inhibit catabolic cellular functions. mTORC1 (mammalian TORC1) phosphorylates and activates S6K1 and S6K2, whose first identified substrate was rpS6 (ribosomal protein S6), a component of the 40S ribosome. Studies over the past decade have uncovered a number of additional S6K1 substrates, revealing multiple levels at which the mTORC1–S6K1 axis regulates cell physiology. The results thus far indicate that the mTORC1–S6K1 axis controls fundamental cellular processes, including transcription, translation, protein and lipid synthesis, cell growth/size and cell metabolism. In the present review we summarize the regulation of S6Ks, their cellular substrates and functions, and their integration within rapidly expanding mTOR (mammalian TOR) signalling networks. Although our understanding of the role of mTORC1–S6K1 signalling in physiology remains in its infancy, evidence indicates that this signalling axis controls, at least in part, glucose homoeostasis, insulin sensitivity, adipocyte metabolism, body mass and energy balance, tissue and organ size, learning, memory and aging. As dysregulation of this signalling axis contributes to diverse disease states, improved understanding of S6K regulation and function within mTOR signalling networks may enable the development of novel therapeutics.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hallmarks of suppressed autophagy indicate that LAP and autophagy may be competing for resources and might not easily co-exist in RPE cells.
“These hallmarks of suppressed autophagy 11,31,32 indicate that LAP and autophagy may be competing for resources and might not easily co-exist in RPE cells.”
From RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye (2017) · cites this paper as [31]
MTOR activation is an indicator of suppressed autophagy, as is p-BECN1 at Ser234 where it is targeted by AKT1 during MTOR activation.
“MTOR activation is an indicator of suppressed autophagy 31 as is p-BECN1 at this Ser234 residue where it is targeted by the serine/threonine kinase AKT1 during MTOR activation.32”
From RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye (2017) · cites this paper as [31]
Cites
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216 · see citing works
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941 · see citing works
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849 · see citing works
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
Collapse: how societies choose to fail or succeed
Lee, V. (2005) · Choice Reviews Online · doi:10.5860/choice.43-1028 · Cited by 3,081 · see citing works
Alessi, D., James, S., Downes, C., Holmes, A. B., Gaffney, P., Reese, C., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 3,047 · see citing works
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works
Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 2,974 · see citing works
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773 · see citing works
Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665 · see citing works
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,645 · see citing works
Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558 · see citing works
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · see citing works
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., & Hall, M. N. (2004) · Nature Cell Biology · doi:10.1038/ncb1183 · Cited by 2,097 · see citing works
Eaten alive: a history of macroautophagy
Yang, Z., & Klionsky, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-814 · Cited by 2,096 · see citing works
Jung, C. H., Ro, S.-H., Cao, J., Otto, N. M., & Kim, D.-H. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.017 · Cited by 2,090 · see citing works
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
Heitman, J., Movva, N. R., & Hall, M. N. (1991) · Science · doi:10.1126/science.1715094 · Cited by 2,010 · see citing works
Mammalian autophagy: core molecular machinery and signaling regulation
Yang, Z., & Klionsky, D. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.014 · Cited by 1,956 · see citing works
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2676 · Cited by 1,943 · see citing works
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911 · see citing works
Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886 · see citing works
Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action
Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810 · see citing works
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798 · see citing works
Vézina, C., KUDELSKI, A., & Sehgal, S. N. (1975) · The Journal of Antibiotics · doi:10.7164/antibiotics.28.721 · Cited by 1,691 · see citing works
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677 · see citing works
Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00568-3 · Cited by 1,555 · see citing works
mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
Cunningham, J. T., Rodgers, J. T., Arlow, D. H., Vazquez, F., Mootha, V. K., & Puigserver, P. (2007) · Nature · doi:10.1038/nature06322 · Cited by 1,488 · see citing works
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413 · see citing works
Guertin, D. A., Stevens, D. M., Thoreen, C. C., Burds, A. A., Kalaany, N. Y., Moffat, J., Brown, M., Fitzgerald, K. J., & Sabatini, D. M. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.007 · Cited by 1,409 · see citing works
Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., & Su, B. (2006) · Cell · doi:10.1016/j.cell.2006.08.033 · Cited by 1,407 · see citing works
Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384 · see citing works
Carracedo, A., Ma, L., Teruya-Feldstein, J., Rojo, F., Salmena, L., Alimonti, A., Egia, A., Sasaki, A. T., Thomas, G., Kozma, S. C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34739 · Cited by 1,381 · see citing works
Regulation of TORC1 by Rag GTPases in nutrient response
Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K.-L. (2008) · Nature Cell Biology · doi:10.1038/ncb1753 · Cited by 1,349 · see citing works
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works
The nuts and bolts of AGC protein kinases
Pearce, L. R., Komander, D., & Alessi, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2822 · Cited by 1,294 · see citing works
Hypothalamic mTOR Signaling Regulates Food Intake
Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works
Phosphorylation and Functional Inactivation of TSC2 by Erk
Ma, L., Chen, Z., Erdjument-Bromage, H., Tempst, P., & Pandolfi, P. P. (2005) · Cell · doi:10.1016/j.cell.2005.02.031 · Cited by 1,268 · see citing works
Holz, M. K., Ballif, B. A., Gygi, S. P., & Blenis, J. (2005) · Cell · doi:10.1016/j.cell.2005.10.024 · Cited by 1,262 · see citing works
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
Huang, J., & Manning, B. D. (2008) · Biochemical Journal · doi:10.1042/bj20080281 · Cited by 1,237 · see citing works
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Sancak, Y., Thoreen, C. C., Peterson, T. R., Lindquist, R. A., Kang, S. A., Spooner, E., Carr, S. A., & Sabatini, D. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.003 · Cited by 1,236 · see citing works
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
Sengupta, S., Peterson, T. R., & Sabatini, D. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.026 · Cited by 1,234 · see citing works
Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00506-2 · Cited by 1,211 · see citing works
Peterson, T. R., Laplante, M., Thoreen, C. C., Sancak, Y., Kang, S. A., Kuehl, W. M., Gray, N. S., & Sabatini, D. M. (2009) · Cell · doi:10.1016/j.cell.2009.03.046 · Cited by 1,202 · see citing works
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Haar, E. V., Lee, S.-I., Bandhakavi, S., Griffin, T. J., & Kim, D. (2007) · Nature Cell Biology · doi:10.1038/ncb1547 · Cited by 1,185 · see citing works
Chung, J., Kuo, C. J., Crabtree, G. R., & Blenis, J. (1992) · Cell · doi:10.1016/0092-8674(92)90643-q · Cited by 1,151 · see citing works
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., & Sabatini, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1432 · Cited by 1,130 · see citing works
mTOR signaling: At the crossroads of plasticity, memory and disease
Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128 · see citing works
The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
Harrington, L. S., Findlay, G. M., Gray, A., Толкачева, Т. А., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403069 · Cited by 1,123 · see citing works
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
Fingar, D. C., Salama, S., Tsou, C., Harlow, E., & Blenis, J. (2002) · Genes & Development · doi:10.1101/gad.995802 · Cited by 1,093 · see citing works
Self-citationHsu, P. P., Kang, S. A., Rameseder, J., Zhang, Y., Ottina, K. A., Lim, D., Peterson, T. R., Choi, Y., Gray, N. S., Yaffe, M. B., et al. (2011) · Science · doi:10.1126/science.1199498 · Cited by 1,084 · see citing works
Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling
Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., & Chen, J. (2001) · Science · doi:10.1126/science.1066015 · Cited by 1,055 · see citing works
Rheb Binds and Regulates the mTOR Kinase
Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., & Avruch, J. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.053 · Cited by 1,005 · see citing works
Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin
Brunn, G. J., Hudson, C. C., Sekulić, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., & Abraham, R. T. (1997) · Science · doi:10.1126/science.277.5322.99 · Cited by 959 · see citing works
Sehgal, S. N., BAKER, H., & Vézina, C. (1975) · The Journal of Antibiotics · doi:10.7164/antibiotics.28.727 · Cited by 949 · see citing works
The gene encoding the splicing factor SF2/ASF is a proto-oncogene
Karni, R., de Stanchina, E., Lowe, S. W., Sinha, R., Mu, D., & Krainer, A. R. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1209 · Cited by 935 · see citing works
Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
Jefferies, H. B. J., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., & Thomas, G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.12.3693 · Cited by 934 · see citing works
Dowling, R. J. O., Zakikhani, M., Fantus, I. G., Pollak, M., & Sonenberg, N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2310 · Cited by 933 · see citing works
García-Martínez, J. M., & Alessi, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20081668 · Cited by 907 · see citing works
Obesity and leptin resistance: distinguishing cause from effect
Myers, M. G., Leibel, R. L., Seeley, R. J., & Schwartz, M. W. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.002 · Cited by 906 · see citing works
Fingar, D. C., Richardson, C. J., Tee, A. R., Cheatham, L. A., Tsou, C., & Blenis, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.200-216.2004 · Cited by 865 · see citing works
Self-citationRegulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase
Wang, X.-M., Li, W., Williams, M. R., Terada, N., Alessi, D., & Proud, C. G. (2001) · EMBO Journal · doi:10.1093/emboj/20.16.4370 · Cited by 862 · see citing works
Yu, Y., Yoon, S.-O., Poulogiannis, G., Yang, Q., Ma, X. M., Villén, J., Kubica, N., Hoffman, G. R., Cantley, L. C., Gygi, S. P., et al. (2011) · Science · doi:10.1126/science.1199484 · Cited by 855 · see citing works
Phosphorylation and Activation of p70 <sup>s6k</sup> by PDK1
Pullen, N., Dennis, P. B., Andjelkovic, M., Dufner, A., Kozma, S. C., Hemmings, B. A., & Thomas, G. (1998) · Science · doi:10.1126/science.279.5351.707 · Cited by 826 · see citing works
Shah, O. J., Wang, Z., & Hunter, T. R. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.026 · Cited by 800 · see citing works
Drosophila S6 kinase: a regulator of cell size.
Montagne, J., Stewart, M. J., Stocker, H., Hafen, E., Kozma, S., & Thomas, G. (1999) · Science · doi:10.1126/science.285.5436.2126 · Cited by 785 · see citing works
Roux, P. P., Ballif, B. A., Anjum, R., Gygi, S. P., & Blenis, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405659101 · Cited by 750 · see citing works
Pende, M., Um, S. H., Mieulet, V., Sticker, M., Goss, V. L., Mestan, J., Mueller, M., Fumagalli, S., Kozma, S. C., & Thomas, G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3112-3124.2004 · Cited by 743 · see citing works
S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth
Dorrello, N. V., Peschiaroli, A., Guardavaccaro, D., Colburn, N. H., Sherman, N. E., & Pagano, M. (2006) · Science · doi:10.1126/science.1130276 · Cited by 731 · see citing works
DeYoung, M. P., Horak, P., Sofer, A., Sgroi, D., & Ellisen, L. W. (2008) · Genes & Development · doi:10.1101/gad.1617608 · Cited by 710 · see citing works
Nojima, H., Tokunaga, C., Eguchi, S., Oshiro, N., Sujuti, H., Yoshino, K., Hara, K., Tanaka, N., Avruch, J., & Yonezawa, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200665200 · Cited by 678 · see citing works
Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.
Beretta, L., Gingras, A., Svitkin, Y. V., Hall, M. N., & Sonenberg, N. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00398.x · Cited by 673 · see citing works
Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase
Price, D. J., Grove, J. R., Calvo, V., Avruch, J., & Bierer, B. E. (1992) · Science · doi:10.1126/science.1380182 · Cited by 666 · see citing works
IMMUNOPHARMACOLOGY OF RAPAMYCIN
Abraham, R. T., & Wiederrecht, G. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.483 · Cited by 653 · see citing works
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasisPreprint
Ruvinsky, I., Sharon, N., Lerer, T., Cohen, H., Stolovich-Rain, M., Nir, T., Dor, Y., Zisman, P., & Meyuhas, O. (2005) · Genes & Development · doi:10.1101/gad.351605 · Cited by 640 · see citing works
IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
Lee, D., Kuo, H.-P., Chen, C., Hsu, J.-M., Chou, C., Wei, Y., Sun, H., Li, L., Ping, B., Huang, W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.058 · Cited by 639 · see citing works
Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKKPreprint
Dan, H. C., Cooper, M. J., Cogswell, P. C., Duncan, J. A., Ting, J. P.-Y., & Baldwin, A. S. (2008) · Genes & Development · doi:10.1101/gad.1662308 · Cited by 638 · see citing works
Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase
Shima, H., Pende, M., Chen, Y., Fumagalli, S., THOMAS, G. V., & Kozma, S. C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6649 · Cited by 636 · see citing works
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes
Hresko, R. C., & Mueckler, M. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508361200 · Cited by 631 · see citing works
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
Jefferies, H. B. J., Reinhard, C., Kozma, S. C., & Thomas, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4441 · Cited by 623 · see citing works
mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells
Murakami, M., Ichisaka, T., Maeda, M., Oshiro, N., Hara, K., Edenhofer, F., Kiyama, H., Yonezawa, K., & Yamanaka, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6710-6718.2004 · Cited by 620 · see citing works
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
Ikenoue, T., Inoki, K., Yang, Q., Zhou, X., & Guan, K. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.119 · Cited by 605 · see citing works
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
Kuo, C. J., Chung, J., Fiorentino, D. F., Flanagan, W. M., Blenis, J., & Crabtree, G. R. (1992) · Nature · doi:10.1038/358070a0 · Cited by 594 · see citing works
Alessi, D. R., Kozlowski, M. T., Weng, Q.-P., MORRICE, N. A., & Avruch, J. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70037-5 · Cited by 574 · see citing works
The Pharmacology of mTOR Inhibition
Guertin, D. A., & Sabatini, D. M. (2009) · Science Signaling · doi:10.1126/scisignal.267pe24 · Cited by 570 · see citing works
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
Harada, H., Andersen, J., Mann, M., Terada, N., & Korsmeyer, S. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.171301998 · Cited by 563 · see citing works
Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase
Chiang, G. G., & Abraham, R. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501707200 · Cited by 562 · see citing works
Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony
Foster, K. G., & Fingar, D. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.094003 · Cited by 532 · see citing works
Self-citationThe mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
Shahbazian, D., Roux, P. P., Mieulet, V., Cohen, M. S., Raught, B., Taunton, J., Hershey, J. W. B., Blenis, J., Pende, M., & Sonenberg, N. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601166 · Cited by 532 · see citing works
TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function
Schalm, S. S., Fingar, D. C., Sabatini, D. M., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00329-4 · Cited by 513 · see citing works
Self-citationFacchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A. S., Gould, C. M., Lowry, C. J., Newton, A. C., Mao, Y., Miao, Q., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.120 · Cited by 508 · see citing works
Identification of a conserved motif required for mTOR signaling.
Schalm, S., & Blenis, J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00762-5 · Cited by 507 · see citing works
The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2
Huang, J., Dibble, C. C., Matsuzaki, M., & Manning, B. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00289-08 · Cited by 504 · see citing works
Peterson, R., Desai, B. N., Hardwick, J. S., & Schreiber, S. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.8.4438 · Cited by 496 · see citing works
PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding
Wang, L., Harris, T. E., Roth, R. A., & Lawrence, J. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702376200 · Cited by 491 · see citing works
Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase
Feng, J., Park, J., Cron, P. D., Heß, D., & Hemmings, B. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406731200 · Cited by 488 · see citing works
Gangloff, Y.-G., Mueller, M., Dann, S. G., Svoboda, P., Sticker, M., Spetz, J.-F., Um, S. H., Brown, E. J., Cereghini, S., Thomas, G., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9508-9516.2004 · Cited by 485 · see citing works
Rapamycin Attenuates Load-Induced Cardiac Hypertrophy in Mice
Shioi, T., McMullen, J., Tarnavski, O., Converso, K., Sherwood, M., Manning, W., & Izumo, S. (2003) · Circulation · doi:10.1161/01.cir.0000057979.36322.88 · Cited by 482 · see citing works
mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer
Dann, S. G., Selvaraj, A., & Thomas, G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.04.002 · Cited by 481 · see citing works
Hannan, K., Brandenburger, Y., Jenkins, A., Sharkey, K., Cavanaugh, A., Rothblum, L., Moss, T., Poortinga, G., McArthur, G., Pearson, R., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8862-8877.2003 · Cited by 473 · see citing works
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
Raught, B., Peiretti, F., Gingras, A., Livingstone, M., Shahbazian, D., Mayeur, G. L., Polakiewicz, R. D., Sonenberg, N., & Hershey, J. W. B. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600193 · Cited by 473 · see citing works
Williams, M. R., Arthur, J. S. C., Balendran, A., KAAY, J. V. D., Poli, V., Cohen, P., & Alessi, D. R. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00441-3 · Cited by 471 · see citing works
Tremblay, F., Brûlé, S., Hee Um, S., Li, Y., Masuda, K., Roden, M., Sun, X. J., Krebs, M., Polakiewicz, R. D., Thomas, G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706517104 · Cited by 465 · see citing works
Inhibition of the immune response by rapamycin, a new antifungal antibiotic
Martel, R. R., Klicius, J., & Galet, S. (1977) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y77-007 · Cited by 464 · see citing works
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
Pende, M., Kozma, S. C., Jaquet, M., Oorschot, V. M. J., Burcelin, R., MARCHAND‐BRUSTEL, Y. L., Klumperman, J., Thorens, B., & Thomas, G. W. (2000) · Nature · doi:10.1038/35050135 · Cited by 452 · see citing works
Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1
Sofer, A., Lei, K., Johannessen, C. M., & Ellisen, L. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.5834-5845.2005 · Cited by 449 · see citing works
Pearson, R. B., Dennis, P. B., Han, J. W., Williamson, N. A., Kozma, S. C., Wettenhall, R. E., & Thomas, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00212.x · Cited by 443 · see citing works
mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
Julien, L.-A., Carriere, A., Moreau, J., & Roux, P. P. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00601-09 · Cited by 433 · see citing works
Can autophagy promote longevity?
Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 429 · see citing works
Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
Dibble, C. C., Asara, J. M., & Manning, B. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00735-09 · Cited by 420 · see citing works
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
Zhang, H., Huang, J., Düvel, K., Boback, B. B., Wu, S., Squillace, R. M., Wu, C., & Manning, B. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006189 · Cited by 393 · see citing works
Peng, T., Golub, T. R., & Sabatini, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5575-5584.2002 · Cited by 393 · see citing works
Ohanna, M., Sobering, A. K., Lapointe, T., Lorenzo, L., Praud, C., Petroulakis, E., Sonenberg, N., Kelly, P. A., Sotiropoulos, A., & Pende, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1231 · Cited by 392 · see citing works
Özeş, O. N., Akça, H., Mayo, L. D., Gustin, J. A., Maehama, T., Dixon, J. E., & Donner, D. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051042298 · Cited by 383 · see citing works
Regulation of the p70 S6 Kinase by Phosphorylation in Vivo
Weng, Q.-P., Kozlowski, M. T., BELHAM, C. M., Zhang, A., Comb, M. J., & Avruch, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16621 · Cited by 375 · see citing works
Identification of S6 Kinase 1 as a Novel Mammalian Target of Rapamycin (mTOR)-phosphorylating Kinase
Holz, M. K., & Blenis, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504045200 · Cited by 361 · see citing works
Smith, E. M., FINN, S. G., Tee, A. R., Browne, G. J., & Proud, C. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414499200 · Cited by 354 · see citing works
Nada, S., Hondo, A., Kasai, A., Koike, M., Saito, K., Uchiyama, Y., & Okada, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.308 · Cited by 341 · see citing works
Functions and regulation of the 70 kDa ribosomal S6 kinases
Fenton, T. R., & Gout, I. T. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.09.018 · Cited by 338 · see citing works
Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro
Isotani, S., Hara, K., Tokunaga, C., Inoue, H., Avruch, J., & Yonezawa, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34493 · Cited by 337 · see citing works
SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs
Ma, X. M., Yoon, S.-O., Richardson, C. J., Jülich, K., & Blenis, J. (2008) · Cell · doi:10.1016/j.cell.2008.02.031 · Cited by 335 · see citing works
Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin
Toschi, A., Lee, E., Xu, L., Garcia, A., Gadir, N., & Foster, D. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00782-08 · Cited by 334 · see citing works
Oh, W. J., Wu, C. C., Kim, S. J., Facchinetti, V., Julien, L.-A., Finlan, M., Roux, P. P., Su, B., & Jacinto, E. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.271 · Cited by 333 · see citing works
Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation
Carrière, A., Cargnello, M., Julien, L.-A., Gao, H., Bonneil, É., Thibault, P., & Roux, P. P. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.078 · Cited by 332 · see citing works
Oshiro, N., Takahashi, R., Yoshino, K., Tanimura, K., Nakashima, A., Eguchi, S., Miyamoto, T., Hara, K., Takehana, K., Avruch, J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702636200 · Cited by 318 · see citing works
Book Review: Collapse: How Societies Choose to Fail or Succeed
Anderson, E. N. (2005) · Journal of Ethnobiology · doi:10.2993/0278-0771(2005)25[143:br]2.0.co;2 · Cited by 316 · see citing works
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt
Zhang, H. H., Lipovsky, A. I., Dibble, C. C., Şahin, M., & Manning, B. D. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.09.019 · Cited by 309 · see citing works
Tang, H., Hornstein, E., Stolovich, M., Levy, G., Livingstone, M., Templeton, D. J., Avruch, J., & Meyuhas, O. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.24.8671-8683.2001 · Cited by 304 · see citing works
The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1
Chou, M. M., & Blenis, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81257-x · Cited by 292 · see citing works
Jones, S. W., ERIKSON, E., Blenis, J., Maller, J. L., & Erikson, R. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.10.3377 · Cited by 280 · see citing works
Frödin, M., Antal, T. L., Dümmler, B. A., Jensen, C. J., Deak, M., Gammeltoft, S., & Biondi, R. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf551 · Cited by 275 · see citing works
Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
Saci, A., Cantley, L. C., & Carpenter, C. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.017 · Cited by 275 · see citing works
ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)
Carriere, A., Romeo, Y., Acosta-Jaquez, H. A., Moreau, J., Bonneil, E., Thibault, P., Fingar, D. C., & Roux, P. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159046 · Cited by 268 · see citing works
Self-citationPearce, L. R., Alton, G., Richter, D. T., Kath, J. C., Lingardo, L., Chapman, J., Hwang, C., & Alessi, D. R. (2010) · Biochemical Journal · doi:10.1042/bj20101024 · Cited by 267 · see citing works
Dennis, P. B., Pullen, N., Kozma, S. C., & Thomas, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6242 · Cited by 249 · see citing works
Use of Sirolimus in Solid Organ Transplantation
Augustine, J. J., Bodziak, K. A., & Hricik, D. E. (2007) · Drugs · doi:10.2165/00003495-200767030-00004 · Cited by 248 · see citing works
S6 Kinase 1 Regulates Estrogen Receptor α in Control of Breast Cancer Cell Proliferation
Yamnik, R. L., Digilova, A., Davis, D. C., Brodt, Z. N., Murphy, C. J., & Holz, M. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807532200 · Cited by 247 · see citing works
Mukhopadhyay, N. K., Price, D. J., Kyriakis, J. M., Pelech, S., Sanghera, J. S., & Avruch, J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50735-9 · Cited by 246 · see citing works
de Groot, R. P., Ballou, L. M., & Sassone‐Corsi, P. (1994) · Cell · doi:10.1016/0092-8674(94)90402-2 · Cited by 232 · see citing works
Chakrabarti, P., English, T., Shi, J., Smas, C. M., & Kandror, K. V. (2010) · Diabetes · doi:10.2337/db09-1602 · Cited by 228 · see citing works
Stolovich, M., Tang, H., Hornstein, E., Levy, G., Cohen, R., Bae, S. S., Birnbaum, M. J., & Meyuhas, O. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.23.8101-8113.2002 · Cited by 228 · see citing works
Soliman, G. A., Acosta-Jaquez, H. A., Dunlop, E. A., Üstünel, B. E., Maj, N. E., Tee, A. R., & Fingar, D. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.096222 · Cited by 227 · see citing works
Self-citationRapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells.
Yeh, W., Bierer, B. E., & McKnight, S. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11086 · Cited by 226 · see citing works
Multiple Independent Inputs Are Required for Activation of the p70 S6 Kinase
Weng, Q.-P., Andrabi, K. I., Kozlowski, M. T., Grove, J. R., & Avruch, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2333 · Cited by 225 · see citing works
TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation
Ou, Y.-H., Torres, M. J., Ram, R. R., Formstecher, É., Roland, C. L., Cheng, T., Brekken, R. A., Wurz, R. P., Tasker, A. S., Polverino, T., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.019 · Cited by 224 · see citing works
IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation
Xie, X., Zhang, D., Zhao, B., Lu, M.-K., You, M., Condorelli, G., Wang, C.-Y., & Guan, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016132108 · Cited by 223 · see citing works
The RSK factors of activating the Ras/MAPK signaling cascade
Carriere, A. (2008) · Frontiers in bioscience · doi:10.2741/3003 · Cited by 218 · see citing works
Narayanan, U., Nalavadi, V., Nakamoto, M., Thomas, G., Ceman, S., Bassell, G. J., & Warren, S. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800055200 · Cited by 216 · see citing works
Chapter 1 Physiological Roles of Ribosomal Protein S6: One of Its Kind
Meyuhas, O. (2008) · International review of cytology · doi:10.1016/s1937-6448(08)00801-0 · Cited by 213 · see citing works
Choo, A. Y., & Blenis, J. (2009) · Cell Cycle · doi:10.4161/cc.8.4.7659 · Cited by 213 · see citing works
S6K1 Plays a Critical Role in Early Adipocyte Differentiation
Carnevalli, L. S., Masuda, K., Frigerio, F., Bacquer, O. L., Um, S. H., Gandin, V., Topisirović, I., Sonenberg, N., Thomas, G., & Kozma, S. C. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.018 · Cited by 205 · see citing works
Westphal, R. S., Coffee, R. L., Marotta, A., Pelech, S., & Wadzinski, B. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.687 · Cited by 202 · see citing works
TOR regulation of AGC kinases in yeast and mammals
Jacinto, E., & Lorberg, A. (2008) · Biochemical Journal · doi:10.1042/bj20071518 · Cited by 201 · see citing works
Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.
Barlund, M. T., Monni, O. M., Kononen, J., Cornelison, R., Torhorst, J. K. H., Sauter, G., OLLI-P, K., & Kallioniemi, A. H. (2000) · PubMed · Cited by 199 · see citing works
SKAR Is a Specific Target of S6 Kinase 1 in Cell Growth Control
Richardson, C. J., Brönstrup, M., Fingar, D. C., Jülich, K., Ballif, B. A., Gygi, S. P., & Blenis, J. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.061 · Cited by 198 · see citing works
Self-citationIn vivo role of the PIF‐binding docking site of PDK1 defined by knock‐in mutation
Collins, B. J., Deák, M., Arthur, J. S., Armit, L., & Alessi, D. (2003) · EMBO Journal · doi:10.1093/emboj/cdg407 · Cited by 198 · see citing works
Kim, J. E., & Chen, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011511898 · Cited by 198 · see citing works
Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis
Blouet, C., Ono, H., & Schwartz, G. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.004 · Cited by 197 · see citing works
Sato, T., Nakashima, A., Guo, L., & Tamanoi, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809207200 · Cited by 196 · see citing works
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
Banerjee, P. T., Ahmad, M. F., Grove, J. R., Kozlosky, C. J., Price, D. J., & Avruch, J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8550 · Cited by 194 · see citing works
Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863 and Multisite Phosphorylation
Foster, K. G., Acosta-Jaquez, H. A., Roméo, Y., Üstünel, B. E., Soliman, G. A., Carriere, A., Roux, P. P., Ballif, B. A., & Fingar, D. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.029637 · Cited by 191 · see citing works
Self-citationCloning and Expression of Two Human p70 S6 Kinase Polypeptides Differing Only at Their Amino Termini
Grove, J. R., Banerjee, P., Balasubramanyam, A., Coffer, P. J., Price, D. J., Avruch, J., & Woodgett, J. R. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.11.5541 · Cited by 188 · see citing works
Critical Role for Hypothalamic mTOR Activity in Energy Balance
Mori, H., Inoki, K., Münzberg, H., Opland, D. M., Faouzi, M., Villanueva, E. C., Ikenoue, T., Kwiatkowski, D. J., MacDougald, O. A., Myers, M. G., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.005 · Cited by 188 · see citing works
New Insights into mTOR Signaling: mTORC2 and Beyond
Alessi, D. R., Pearce, L. R., & García‐Martínez, J. M. (2009) · Science Signaling · doi:10.1126/scisignal.267pe27 · Cited by 188 · see citing works
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
Liu, L., Li, F., Cardelli, J. A., Martin, K. A., Blenis, J., & Huang, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209691 · Cited by 187 · see citing works
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression
Whitney, M. L., Jefferson, L. S., & Kimball, S. R. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.079 · Cited by 186 · see citing works
Aguilar, V. M., Alliouachene, S., Sotiropoulos, A., Sobering, A. K., Athéa, Y., Djouadi, F., Miraux, S., Thiaudière, E., Foretz, M., Viollet, B., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.006 · Cited by 182 · see citing works
Romanelli, A., Martin, K. A., Toker, A., & Blenis, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2921 · Cited by 180 · see citing works
Phospholipase D1 is an effector of Rheb in the mTOR pathway
Sun, Y., Fang, Y., Yoon, M., Zhang, C., Roccio, M., Zwartkruis, F. J. T., Armstrong, M. D., Brown, H. A., & Chen, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712268105 · Cited by 179 · see citing works
mTOR mediated anti-cancer drug discovery
Liu, Q., Thoreen, C. C., Wang, J., Sabatini, D. M., & Gray, N. S. (2009) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2009.12.001 · Cited by 177 · see citing works
Saitoh, M., Pullen, N., Brennan, P., Cantrell, D. A., Dennis, P. B., & Thomas, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201745200 · Cited by 177 · see citing works
Kozma, S. C., Ferrari, S. M., Bassand, P., Siegmann, M., Totty, N. F., & Thomas, G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7365 · Cited by 174 · see citing works
Abizaid, A., & Costa, J. R. (2010) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.109.891192 · Cited by 173 · see citing works
Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth
Acosta-Jaquez, H. A., Keller, J. A., Foster, K. G., Üstünel, B. E., Soliman, G. A., Feener, E. P., Ballif, B. A., & Fingar, D. C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01665-08 · Cited by 167 · see citing works
Self-citationFerrari, S. M., Bannwarth, W., Morley, S., Totty, N. F., & Thomas, G. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.7282 · Cited by 167 · see citing works
Han, J., Pearson, R. B., Dennis, P. B., & Thomas, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21396 · Cited by 165 · see citing works
Characterization of S6K2, a novel kinase homologous to S6K1
Lee-Fruman, K. K., Kuo, C. J., Lippincott, J., Terada, N., & Blenis, J. (1999) · Oncogene · doi:10.1038/sj.onc.1202894 · Cited by 162 · see citing works
The Late Endosome is Essential for mTORC1 Signaling
Flinn, R. J., Yan, Y., Goswami, S., Parker, P. J., & Backer, J. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-09-0756 · Cited by 158 · see citing works
Rictor is a novel target of p70 S6 kinase-1
Treins, C., Warne, P. H., Magnuson, M. A., Pende, M., & Downward, J. (2009) · Oncogene · doi:10.1038/onc.2009.401 · Cited by 154 · see citing works
Gout, I. T., Minami, T., Hara, K., Tsujishita, Y., Filonenko, V. V., Waterfield, M. D., & Yonezawa, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30061 · Cited by 148 · see citing works
Dennis, P. B., Pullen, N., Pearson, R. B., Kozma, S. C., & Thomas, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.14845 · Cited by 142 · see citing works
Ali, S. M., & Sabatini, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500125200 · Cited by 138 · see citing works
Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticityPreprint
Antion, M. D., Merhav, M., Hoeffer, C. A., Reis, G. F., Kozma, S. C., Thomas, G., Schuman, E. M., Rosenblum, K., & Klann, E. (2008) · Learning & Memory · doi:10.1101/lm.661908 · Cited by 138 · see citing works
Zheng, M., Wang, Y., Wu, X., Wu, S., Lu, B.-J., Dong, M., Zhang, H., Sun, P., Lin, S., Guan, K., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2168 · Cited by 137 · see citing works
Patursky-Polischuk, I., Stolovich-Rain, M., Hausner-Hanochi, M., Kasir, J., Cybulski, N., Avruch, J., Rüegg, M. A., Hall, M. N., & Meyuhas, O. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00980-08 · Cited by 135 · see citing works
McMullen, J., Shioi, T., Zhang, L., Tarnavski, O., Sherwood, M., Dorfman, A., Longnus, S., Pende, M., Martin, K., Blenis, J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.14.6231-6240.2004 · Cited by 133 · see citing works
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
McManus, E. J., Collins, B., Ashby, P. R., Prescott, A. R., Murray-Tait, V., Armit, L. J., Arthur, J. S. C., & Alessi, D. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600218 · Cited by 132 · see citing works
PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation
Hahn, K., Miranda, M., Francis, V. A., Vendrell, J., Zorzano, A., & Teleman, A. A. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.015 · Cited by 131 · see citing works
S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response
Lai, K. P., Leong, W. F., Chau, J. F. L., Jia, D., Zeng, L., Liu, H., He, L., Hao, A., Zhang, H., Meek, D. W., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.166 · Cited by 130 · see citing works
Role of Mammalian Target of Rapamycin Signaling in Compensatory Renal Hypertrophy
Chen, J., Chen, J., Neilson, E. G., & Harris, R. C. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004100894 · Cited by 126 · see citing works
Chapter 3 Ribosomal Protein S6 Kinase
Meyuhas, O., & Dreazen, A. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)90003-5 · Cited by 125 · see citing works
Structural and functional analysis of pp70S6k.
Cheatham, L. A., Monfar, M., Chou, M. M., & Blenis, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11696 · Cited by 125 · see citing works
New drug-eluting stent concepts
Wessely, R. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.14 · Cited by 125 · see citing works
Üstünel, B. E., Magnuson, B., Acosta-Jaquez, H. A., Keller, J. A., Feener, E. P., & Fingar, D. C. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05437-11 · Cited by 124 · see citing works
Self-citationHuang, J., Wu, S., Wu, C., & Manning, B. D. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0975 · Cited by 123 · see citing works
Joung, S. M., Park, Z., Rani, S., Takeuchi, O., Akira, S., & Lee, J. Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903534 · Cited by 121 · see citing works
Wang, L., Lawrence, J. C., Sturgill, T. W., & Harris, T. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.002907 · Cited by 118 · see citing works
Ferrari, S. M., Pearson, R. B., Siegmann, M., Kozma, S. C., & Thomas, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85389-9 · Cited by 113 · see citing works
Flagged first, then by citations
4 of the 241 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The PI3K Pathway in Human Disease
Fruman, D. A., Chiu, H., Hopkins, B. D., Bagrodia, S., Cantley, L. C., & Abraham, R. T. (2017) · Cell · doi:10.1016/j.cell.2017.07.029 · Cited by 2,749 · see citing works
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Bouhaddou, M., Memon, D., Meyer, B., White, K. M., Rezelj, V. V., Marrero, M. C., Polacco, B. J., Melnyk, J. E., Ulferts, S., Kaake, R. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.034 · Cited by 998 · see citing works
mTORC1 signaling and the metabolic control of cell growth
Ben‐Sahra, I., & Manning, B. D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.012 · Cited by 641 · see citing works
Marçais, A., Cherfils‐Vicini, J., Viant, C., Degouve, S., Viel, S., Fenis, A., Rabilloud, J., Mayol, K., Tavares, A., Bienvenu, J., et al. (2014) · Nature Immunology · doi:10.1038/ni.2936 · Cited by 611 · see citing works
Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method
Lin, J., Fallahi‐Sichani, M., & Sorger, P. K. (2015) · Nature Communications · doi:10.1038/ncomms9390 · Cited by 562 · see citing works
UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication
Melber, A., & Haynes, C. M. (2018) · Cell Research · doi:10.1038/cr.2018.16 · Cited by 488 · see citing works
mTOR substrate phosphorylation in growth control
Battaglioni, S., Benjamin, D., Wälchli, M., Maier, T., & Hall, M. N. (2022) · Cell · doi:10.1016/j.cell.2022.04.013 · Cited by 437 · see citing works
Multiple Roles of the Small GTPase Rab7
Guerra, F., & Bucci, C. (2016) · Cells · doi:10.3390/cells5030034 · Cited by 394 · see citing works
Signaling Pathways Involved in the Regulation of mRNA Translation
Roux, P. P., & Topisirović, I. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00070-18 · Cited by 314 · see citing works
Cellular metabolic and autophagic pathways: Traffic control by redox signaling
Dodson, M. B., Darley-Usmar, V. M., & Zhang, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.014 · Cited by 325 · see citing works
Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P., & Klann, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.022 · Cited by 316 · see citing works
Growing knowledge of the mTOR signaling network
Huang, K., & Fingar, D. C. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.011 · Cited by 301 · see citing works
Self-citationmTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction
Igarashi, M., & Guarente, L. (2016) · Cell · doi:10.1016/j.cell.2016.05.044 · Cited by 302 · see citing works
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition
Boudreau, A., Purkey, H. E., Hitz, A., Robarge, K., Peterson, D., Labadie, S., Kwong, M., Hong, R., Gao, M., Del Nagro, C., et al. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2143 · Cited by 280 · see citing works
Jain, M. V., Paczulla, A., Klonisch, T. C., Dimgba, F. N., Rao, S. B., Roberg, K. B., Schweizer, F., Lengerke, C., Davoodpour, P., Palicharla, V. R., et al. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12001 · Cited by 241 · see citing works
The S6K protein family in health and disease
Tavares, M. R., Pavan, I. C. B., do Amaral, C. L., Meneguello, L., Luchessi, A. D., & Simabuco, F. M. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.03.001 · Cited by 237 · see citing works
The unique biology of germinal center B cells
Young, C., & Brink, R. A. (2021) · Immunity · doi:10.1016/j.immuni.2021.07.015 · Cited by 232 · see citing works
Abnormal mTOR Activation in Autism
Winden, K. D., Ebrahimi‐Fakhari, D., & Şahin, M. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061747 · Cited by 222 · see citing works
AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
Kazyken, D., Magnuson, B., Bodur, Ç., Acosta-Jaquez, H. A., Zhang, D., Tong, X., Barnes, T. M., Steinl, G. K., Patterson, N., Altheim, C. H., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aav3249 · Cited by 222 · see citing works
Self-citationAkt and mTOR in B Cell Activation and Differentiation
Limon, J. J., & Fruman, D. A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00228 · Cited by 215 · see citing works
Redox control of skeletal muscle atrophy.
Powers, S. K., Morton, A. B., Ahn, B., & Smuder, A. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.021 · Cited by 207 · see citing works
The Translational Regulation in mTOR Pathway
Yang, M., Lu, Y., Piao, W., & Jin, H. (2022) · Biomolecules · doi:10.3390/biom12060802 · Cited by 206 · see citing works
Zhao, C., Yang, C., Wai, S. T. C., Zhang, Y., P. Portillo, M., Paoli, P., Wu, Y., San Cheang, W., Liu, B., Carpéné, C., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1501658 · Cited by 199 · see citing works
Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise
Brook, M. S., Wilkinson, D. J., Phillips, B. E., Pérez‐Schindler, J., Philp, A., Smith, K., & Atherton, P. J. (2015) · Acta Physiologica · doi:10.1111/apha.12532 · Cited by 193 · see citing works
Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation
Tan, H. W. S., Sim, A. Y. L., & Long, Y. C. (2017) · Nature Communications · doi:10.1038/s41467-017-00369-y · Cited by 193 · see citing works
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism
Huber, K. M., Klann, E., Costa-Mattioli, M., & Zukin, R. S. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2656-15.2015 · Cited by 167 · see citing works
The Hallmarks of Flavonoids in Cancer
Ponte, L. G. S., Pavan, I. C. B., Mancini, M. C. S., da Silva, L. G. S., Morelli, A. P., Severino, M. B., Bezerra, R. M. N., & Simabuco, F. M. (2021) · Molecules · doi:10.3390/molecules26072029 · Cited by 184 · see citing works
The expanding role of mTOR in cancer cell growth and proliferation
Cargnello, M., Tcherkezian, J., & Roux, P. P. (2015) · Mutagenesis · doi:10.1093/mutage/geu045 · Cited by 168 · see citing works
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes
Chen, J., Torcia, S., Xie, F., Lin, C.-J., Çakmak, H., Franciosi, F., Horner, K., Onodera, C. S., Song, J. S., Cedars, M. I., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2873 · Cited by 167 · see citing works
You, J.-S., Lincoln, H. C., Kim, C.-R., Frey, J. W., Goodman, C. A., Zhong, X.-P., & Hornberger, T. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.531392 · Cited by 163 · see citing works
Signaling and Regulation of the Mitochondrial Unfolded Protein ResponsePreprint
Naresh, N. U., & Haynes, C. M. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033944 · Cited by 163 · see citing works
The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration
Liu, Y., Miao, L., Liang, F., Huang, H., Teng, X., Li, S., Nuriddinov, J., Selzer, M. E., & Hu, Y. (2014) · Nature Communications · doi:10.1038/ncomms6416 · Cited by 158 · see citing works
AGC kinases, mechanisms of regulation and innovative drug development
Leroux, A. E., Schulze, J. O., & Biondi, R. M. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.05.011 · Cited by 155 · see citing works
TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging
Blackwell, T. K., Sewell, A. K., Wu, Z., & Han, M. (2019) · Genetics · doi:10.1534/genetics.119.302504 · Cited by 141 · see citing works
mTOR function and therapeutic targeting in breast cancer.
Hare, S. H., & Harvey, A. (2017) · PubMed Central · Cited by 150 · see citing works
Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis?
Kob, R., Bollheimer, L. C., Bertsch, T., Fellner, C., Djukic, M., Sieber, C. C., & Fischer, B. E. (2015) · Biogerontology · doi:10.1007/s10522-014-9539-7 · Cited by 151 · see citing works
Zhou, L., Xie, Y., Li, S., Liang, Y., Qiu, Q., Lin, H., & Zhang, Q. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0350-3 · Cited by 149 · see citing works
Fajgenbaum, D. C., Langan, R.-A., Japp, A. S., Partridge, H. L., Pierson, S. K., Singh, A., Arenas, D. J., Ruth, J. R., Nabel, C. S., Stone, K., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126091 · Cited by 147 · see citing works
Pérez‐Revuelta, B. I., Hettich, M. M., Ciociaro, A., Rotermund, C., Kahle, P. J., Krauß, S., & Monte, D. A. D. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.175 · Cited by 147 · see citing works
Direct effects of airborne PM2.5 exposure on macrophage polarizations
Zhao, Q., Chen, H., Yang, T., Rui, W., Liu, F., Zhang, F., Zhao, Y. X., & Ding, W. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.03.033 · Cited by 145 · see citing works
Fasting enhances cold resistance in fish through stimulating lipid catabolism and autophagy
Lu, D., Ma, Q., Wang, J., Li, L., Han, S., Limbu, S. M., Li, D., Chen, L., Zhang, M., & Du, Z. (2019) · The Journal of Physiology · doi:10.1113/jp277091 · Cited by 143 · see citing works
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects
Cai, H., Dong, L., & Liu, F. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.11.011 · Cited by 142 · see citing works
Xu, Z., Feng, W., Shen, Q., Yu, N., Yu, K., Wang, S., Chen, Z., Shioda, S., & Guo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2016.0620 · Cited by 143 · see citing works
TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in <i>BRAF-</i> Mutant Melanoma
Corcoran, R. B., Rothenberg, S. M., Hata, A. N., Faber, A. C., Piris, A., Nazarian, R. M., Brown, R. D., Godfrey, J. T., Winokur, D., Walsh, J., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005753 · Cited by 140 · see citing works
Zhou, C., Huang, C., Wang, J., Huang, H., Li, J., Xie, Q., Liu, Y., Zhu, J., Li, Y., Zhang, D., et al. (2017) · Oncogene · doi:10.1038/onc.2017.14 · Cited by 139 · see citing works
Sharma, G., Guardia, C. M. A., Roy, A., Vassilev, A. P., Sarić, A., Griner, L. N., Marugán, J., Ferrer, M., Bonifacino, J. S., & Depamphilis, M. (2019) · Autophagy · doi:10.1080/15548627.2019.1586257 · Cited by 131 · see citing works
Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
Wu, Z. R., Yan, L., Liu, Y. T., Cao, L., Guo, Y., Zhang, Y., Yao, H., Cai, L., Shang, H. B., Rui, W. W., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06853-3 · Cited by 135 · see citing works
Liu, D., Wang, S., Liu, S., Wang, Q., Che, X., & Wu, G. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101270 · Cited by 134 · see citing works
EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice
Arif, A., Terenzi, F., Potdar, A. A., Jia, J., Sacks, J., China, A., Halawani, D., Vasu, K. I., Li, X., Brown, J. M., et al. (2017) · Nature · doi:10.1038/nature21380 · Cited by 129 · see citing works
Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy
Jordan, T. X., & Randall, G. C. (2017) · Journal of Virology · doi:10.1128/jvi.02020-16 · Cited by 129 · see citing works
CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation
Shuda, M., Velásquez, C., Cheng, E., Cordek, D. G., Kwun, H. J., Chang, Y., & Moore, P. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505787112 · Cited by 127 · see citing works
Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
Barini, E., Antico, O., Zhao, Y., Asta, F., Tucci, V., Catelani, T., Marotta, R., Xu, H., & Gasparini, L. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0082-7 · Cited by 126 · see citing works
Guichard, S. M., Curwen, J., Bihani, T., D’Cruz, C. M., Yates, J. W. T., Grondine, M. R., Howard, Z., Davies, B. R., Bigley, G., Klinowska, T. C. M., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0365 · Cited by 126 · see citing works
Zeng, Z., Shi, Y. X., Tsao, T., Qiu, Y., Kornblau, S. M., Baggerly, K., Liu, W., Jessen, K., Liu, Y., Kantarjian, H. M., et al. (2012) · Blood · doi:10.1182/blood-2011-11-393934 · Cited by 125 · see citing works
Liu, M., Bai, J., He, S., Villarreal, R., Hu, D., Zhang, C., Yang, X., Liang, H., Slaga, T. J., Yu, Y., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.018 · Cited by 122 · see citing works
Mutschelknaus, L., Azimzadeh, O., Heider, T., Winkler, K., Vetter, M. H. F., Kell, R., Tapio, S., Merl‐Pham, J., Huber, S. M., Edalat, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12403-6 · Cited by 125 · see citing works
tRNA overexpression rescues peripheral neuropathy caused by mutations in tRNA synthetase
Zuko, A., Mallik, M., Thompson, R., Spaulding, E., Wienand, A., Been, M., Tadenev, A., van Bakel, N., Sijlmans, C., Santos, L. A., et al. (2021) · Science · doi:10.1126/science.abb3356 · Cited by 111 · see citing works
Bond, P. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-016-0118-y · Cited by 121 · see citing works
USP1 deubiquitinates Akt to inhibit PI3K‐Akt‐FoxO signaling in muscle during prolonged starvation
Goldbraikh, D., Neufeld, D., Eid‐Mutlak, Y., Lasry, I., Gilda, J. E., Parnis, A., & Cohen, S. (2020) · EMBO Reports · doi:10.15252/embr.201948791 · Cited by 120 · see citing works
Cervantes-Madrid, D., Romero, Y., & Dueñas‐González, A. (2015) · BioMed Research International · doi:10.1155/2015/690492 · Cited by 119 · see citing works
Patwardhan, P. P., Surriga, O., Beckman, M. J., de Stanchina, E., DeMatteo, R. P., Tap, W. D., & Schwartz, G. K. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2576 · Cited by 118 · see citing works
Vergès, B. L., & Cariou, B. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.09.014 · Cited by 117 · see citing works
Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications
Simone, V. D., d’Avenia, M., Argentiero, A., Felici, C., Rizzo, F. M., Pergola, G. D., & Silvestris, F. (2016) · The Oncologist · doi:10.1634/theoncologist.2015-0351 · Cited by 120 · see citing works
Eukaryotic translation initiation factors as promising targets in cancer therapy
Hao, P., Yu, J.-J., Ward, R., Liu, Y., Hao, Q., An, S., & Xu, T.-R. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00607-9 · Cited by 95 · see citing works
Ho, Y., & Gasch, A. P. (2015) · Current Genetics · doi:10.1007/s00294-015-0491-0 · Cited by 110 · see citing works
The Enigma of Rapamycin Dosage
Mukhopadhyay, S., Frías, M. A., Chatterjee, A., Yellen, P., & Foster, D. A. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0720 · Cited by 114 · see citing works
An overview of rapamycin: from discovery to future perspectives
Yoo, Y. J., Kim, H., Park, S. R., & Yoon, Y. J. (2016) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-016-1834-7 · Cited by 114 · see citing works
Mitochondrial unfolded protein response: An emerging pathway in human diseases
Zhu, L., Zhou, Q., He, L., & Chen, L. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.013 · Cited by 115 · see citing works
Adhikari, D., Risal, S., Liu, K., & Shen, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053810 · Cited by 108 · see citing works
The impact of tumor stroma on drug response in breast cancer
Dittmer, J., & Leyh, B. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.05.006 · Cited by 103 · see citing works
The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
Bjedov, I., & Rallis, C. (2020) · Genes · doi:10.3390/genes11091043 · Cited by 106 · see citing works
Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K/AKT/mTOR, and ROS pathways
Wang, W., Dong, X., Liu, Y., Ni, B., Sai, N., You, L., Sun, M., Yao, Y., Qu, C., Yin, X., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110661 · Cited by 105 · see citing works
Caccamo, A., Branca, C., Talboom, J. S., Shaw, D. M., Turner, D., Ma, L., Messina, A. A., Huang, Z., Wu, J., & Oddo, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2781-15.2015 · Cited by 101 · see citing works
Tissue‐specific insulin signaling in the regulation of metabolism and aging
Zhang, J., & Liu, F. (2014) · IUBMB Life · doi:10.1002/iub.1293 · Cited by 100 · see citing works
Turgeon, N., Blais, M., Gagné, J. M., Tardif, V., Boudreau, F., Perreault, N., & Asselin, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073785 · Cited by 101 · see citing works
González, A., Shimobayashi, M., Eisenberg, T., Merle, D. A., Pendl, T., Hall, M. N., & Moustafa, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120250 · Cited by 96 · see citing works
mTORC1 signaling and IL‐17 expression: Defining pathways and possible therapeutic targets
Ren, W., Yin, J., Duan, J., Liu, G., Tan, B., Yang, G., Wu, G., Bazer, F. W., Peng, Y., & Yin, Y. (2015) · European Journal of Immunology · doi:10.1002/eji.201545886 · Cited by 101 · see citing works
Bodur, Ç., Kazyken, D., Huang, K., Üstünel, B. E., Siroky, K. A., Tooley, A. S., Gonzalez, I. E., Foley, D. H., Acosta-Jaquez, H. A., Barnes, T. M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696164 · Cited by 97 · see citing works
Self-citationFallahi‐Sichani, M., Moerke, N. J., Niepel, M., Zhang, T., Gray, N. S., & Sorger, P. K. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145877 · Cited by 99 · see citing works
Hong, S., Zhao, B., Lombard, D. B., Fingar, D. C., & Inoki, K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.520734 · Cited by 98 · see citing works
Self-citationGao, S., Duan, C., Gao, G., Wang, X., & Yang, H. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.03.006 · Cited by 98 · see citing works
Dutta, D., Xu, J., Dirain, M. L. S., & Leeuwenburgh, C. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.06.011 · Cited by 99 · see citing works
Kettenbach, A. N., Deng, L., Wu, Y., Baldissard, S., Adamo, M. E., Gerber, S. A., & Moseley, J. B. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.045245 · Cited by 98 · see citing works
Morandi, F., Morandi, B., Horenstein, A. L., Chillemi, A., Quarona, V., Zaccarello, G., Carrega, P., Ferlazzo, G., Mingari, M. C., Moretta, L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4693 · Cited by 97 · see citing works
p70 Ribosomal protein S6 kinase ( Rps6kb1 ): an update
Bahrami-B, F., Ataie-Kachoie, P., Pourgholami, M. H., & Morris, D. L. (2014) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2014-202560 · Cited by 96 · see citing works
Status of mTOR Activity May Phenotypically Differentiate Senescence and Quiescence
Cho, S., & Hwang, E. S. (2012) · Molecules and Cells · doi:10.1007/s10059-012-0042-1 · Cited by 97 · see citing works
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling
Halicka, H. D., Zhao, H. L., Li, J., Lee, Y., Hsieh, T., WU, J. M., & Darżynkiewicz, Z. (2012) · Aging · doi:10.18632/aging.100521 · Cited by 95 · see citing works
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
Mahoney, S. J., Narayan, S., Molz, L., Berstler, L. A., Kang, S. A. W., Vlasuk, G. P., & Saiah, E. (2018) · Nature Communications · doi:10.1038/s41467-018-03035-z · Cited by 95 · see citing works
Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae
Gjessing, M. C., Yutin, N., Tengs, T., Senkevich, T. G., Koonin, E. V., Rønning, H. P., Alarcón, M., Ylving, S., Lie, K. I., Saure, B., et al. (2015) · Journal of Virology · doi:10.1128/jvi.01174-15 · Cited by 95 · see citing works
Al‐Ali, H., Ding, Y., Slepak, T. I., Wu, W., Sun, Y., Martinez‐Ondaro, Y., Xu, X., Lemmon, V., & Bixby, J. L. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0931-17.2017 · Cited by 94 · see citing works
MAPK3/1 participates in the activation of primordial follicles through mTORC1‐KITL signaling
Zhao, Y., Zhang, Y., Li, J., Zheng, N., Xu, X., Yang, J., Xia, G., & Zhang, M. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25868 · Cited by 93 · see citing works
The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity
Bonifacio, A., Sanvee, G. M., Bouitbir, J., & Krähenbühl, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.04.010 · Cited by 93 · see citing works
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressorPreprint
Kobayashi, M., Wilson, A. C., Chao, M. V., & Mohr, I. (2012) · Genes & Development · doi:10.1101/gad.190157.112 · Cited by 93 · see citing works
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia
Järås, M., Miller, P. G., Chu, L. P., Puram, R. V., Fink, E. C., Schneider, R. K., Al-Shahrour, F., Peña, P., Breyfogle, L. J., Hartwell, K. A., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20131033 · Cited by 92 · see citing works
Translation factors and ribosomal proteins control tumor onset and progression: how?
Loreni, F., Mancino, M., & Biffo, S. (2013) · Oncogene · doi:10.1038/onc.2013.153 · Cited by 90 · see citing works
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis
Chen, Q. Y., & Costa, M. (2018) · Molecular Pharmacology · doi:10.1124/mol.118.112268 · Cited by 92 · see citing works
Ras drives malignancy through stem cell crosstalk with the microenvironment
Yuan, S., Stewart, K. S., Yang, Y., Abdusselamoglu, M. D., Parigi, S. M., Feinberg, T. Y., Tumaneng, K., Yang, H., Levorse, J. M., Polak, L., et al. (2022) · Nature · doi:10.1038/s41586-022-05475-6 · Cited by 92 · see citing works
Gonzalez, A. M., Hoffman, J. R., Stout, J. R., Fukuda, D. H., & Willoughby, D. S. (2015) · Sports Medicine · doi:10.1007/s40279-015-0450-4 · Cited by 94 · see citing works
mTOR inhibition and p53 activation, microRNAs: The possible therapy against pandemic COVID-19
Ramaiah, M. J. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.100765 · Cited by 90 · see citing works
Beyond controlling cell size: functional analyses of S6K in tumorigenesis
Wu, X., Xie, W., Xie, W.-X., Wei, W.-Y., & Guo, J.-P. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05081-4 · Cited by 77 · see citing works
- Authors
- Magnuson, B., Ekim, B., & Fingar, D. C.
- Affiliations
- University of Michigan (US)
- Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, U.S.A.
- Corresponding author
- Magnuson, Brian
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2011-12-14
- Volume
- 441
- Issue
- 1
- Pages
- 1-21
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2312282875
- Cited by
- 1,015
- References
- 241
- Citations by year
- 2026: 52 · 2025: 57 · 2024: 63 · 2023: 67 · 2022: 57 · 2021: 72 · 2020: 69 · 2019: 82 · 2018: 87 · 2017: 85 · 2016: 73 · 2015: 84 · 2014: 68 · 2013: 64 · 2012: 34
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk078135-03)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-078135, R01DK100722)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- S6K, S6K1, S6K2, mTORC1, TOR signaling, ribosomal protein S6, translational regulation, glucose homeostasis, insulin sensitivity, adipocyte metabolism, energy balance, organ size, learning and memory, aging, disease therapeutics
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Signal Transduction, Ribosomal Protein S6 Kinases, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review