The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat
Open accessAbstract
The contribution of cystathionine gamma-lyase, cystathionine beta-synthase and cysteine aminotransferase coupled to 3-mercaptopyruvate sulphurtransferase to cysteine desulphhydration in rat liver and kidney was assessed with four different assay systems. Cystathionine gamma-lyase and cystathionine beta-synthase were active when homogenates were incubated with 280 mM-L-cysteine and 3 mM-pyridoxal 5′-phosphate at pH 7.8. Cysteine aminotransferase in combination with 3-mercaptopyruvate sulphurtransferase catalysed essentially all of the H2S production from cysteine at pH 9.7 with 160 mM-L-cysteine, 2 mM-pyridoxal 5′-phosphate, 3 mM-2-oxoglutarate and 3 mM-dithiothreitol. At more-physiological concentrations of cysteine (2 mM) cystathionine gamma-lyase and cystathionine beta-synthase both appeared to be active in cysteine desulphhydration, whereas the aminotransferase pathway did not. The effect of inhibition of cystathionine gamma-lyase by a suicide inactivator, propargylglycine, in the intact rat was also investigated; there was no significant effect of propargylglycine administration on the urinary excretion of total 35S, 35SO4(2-) or [35S]taurine formed from labelled dietary cysteine.
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Cites
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Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur
Stipanuk, M. H., & Ueki, I. (2011) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-009-9006-9 · Cited by 494
Self-citationCO AS A CELLULAR SIGNALING MOLECULE
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Asimakopoulou, A., Panopoulos, P., Chasapis, C. T., Coletta, C., Zhou, Z., Cirino, G., Giannis, A., Szabo, C., Spyroulias, G. A., & Papapetropoulos, A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12171 · Cited by 393
H2S generated by heart in rat and its effects on cardiac function
Geng, B., Yang, J., Qi, Y., Zhao, J., Pang, Y., Du, J., & Tang, C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.130 · Cited by 342
Metadata
- Authors
- Stipanuk, M. H., & Beck, P. W.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1982-08-15
- Volume
- 206
- Issue
- 2
- Pages
- 267-277
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W1764016564
- Cited by
- 710
- References
- 17
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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