The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture
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The activities of 3-phosphoglycerate dehydrogenase and serine hydroxymethyltransferase increased markedly during the transition of hepatoma cells from a resting non-proliferating culture into the proliferating growth phase. Activities declined as cells reached confluency and entered the plateau growth phase. This pattern was paralleled by changes in [14C]serine incorporation into nucleic acids. The experiments support the hypothesis that the biosynthesis of serine is metabolically coupled to its utilization for nucleotide precursor formation in cancer cells.
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Serine is the primary carbon donor to the tetrahydrofolate cycle, which is required for both purine and pyrimidine nucleotide biosynthesis.
“With respect to proliferating cells such as cancer, serine is the primary carbon donor to the tetrahydrofolate (THF) cycle, which is required for both purine and pyrimidine nucleotide biosynthesis (Figure 6)(Snell et al., 1987).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Snell et al., 1987
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Cites
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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
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Targeting Metabolism for Cancer Therapy
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Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma
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- Authors
- Snell, K., Natsumeda, Y., & Weber, G.
- Affiliations
- Indiana University School of Medicine (US)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1987-07-15
- Volume
- 245
- Issue
- 2
- Pages
- 609-612
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1148165
- OpenAlex
- W2256377236
- Cited by
- 86
- References
- 22
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA642510, CA 13526)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- serine metabolism, hepatoma cells, cell proliferation, 3-phosphoglycerate dehydrogenase, serine hydroxymethyltransferase, nucleotide synthesis, growth phase, cancer metabolism
- MeSH terms
- Animals, Carbohydrate Dehydrogenases, Cell Count, Cell Division, Cell Line, Liver Neoplasms, Experimental, Nucleic Acids, Serine, Glycine Hydroxymethyltransferase, Phosphoglycerate Dehydrogenase
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