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Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes
Open accessAbstract
The latent forms of stromelysin and collagenase from human gingival fibroblasts were purified to homogeneity. These latent proenzymes underwent serial small reductions in Mr upon activation by treatment with either 4-aminophenylmercuric acetate or trypsin. Similar shifts in Mr and activation kinetics were observed upon identical treatments of either recombinant prostromelysin or procollagenase. Prostromelysin showed a lag between activation and Mr fall, suggesting an initial activation by conformational change. Collagenase activity was enhanced up to 12-fold by either natural or recombinant stromelysin in the presence of trypsin or 4-aminophenylmercuric acetate. Stromelysin caused a further apparent decrease in the Mr of procollagenase. Since these important connective-tissue-degrading enzymes are usually co-ordinately produced by cells, a cascade mechanism is proposed in which collagenase is activated by stromelysin.
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Cited by
Goldberg, G. I., Marmer, B. L., Grant, G. A., Eisen, A. Z., Wilhelm, S., & He, C. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.21.8207 · Cited by 586
Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.
Wu, J. J., Lark, M. W., Chun, L. E., & Eyre, D. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67640-4 · Cited by 259
Tissue inhibitors of metalloproteinases in liver fibrosis
Iredale, J. P. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(96)00118-5 · Cited by 165
Moilanen, M., Sorsa, T., Stenman, M., Nyberg, P., Lindy, O., Vesterinen, J., Paju, A., Konttinen, Y. T., Stenman, U.-H., & Salo, T. (2003) · Biochemistry · doi:10.1021/bi020582s · Cited by 111
Ito, A., Sato, T., Iga, T., & Mori, Y. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81127-a · Cited by 100
Metadata
- Authors
- Murphy, G., Cockett, M. I., Stephens, P. E., Smith, B. J., & Docherty, A. J. P.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1987-11-15
- Volume
- 248
- Issue
- 1
- Pages
- 265-268
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1772675489
- Cited by
- 464
- References
- 0
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Murphy, G., Cockett, M. I., Stephens, P. E., Smith, B. J., & Docherty, A. J. P. (1987). Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes. Biochemical Journal. https://doi.org/10.1042/bj2480265
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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