The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.
Open accessAbstract
Human recombinant stromelysin-1 was shown to cleave four types of collagen (types II, IX, X, and XI) prepared from bovine and rat cartilages at specific sites. Stromelysin-1 cleaved salt-soluble native molecules of type IX collagen into two main triple-helical fragments, COL1 and COL2,3. Protein microsequencing identified the exact cleavage sites in the NC2 domain of all three chains, alpha 1(IX), alpha 2(IX), and alpha 3(IX). Stromelysin-1 also acted as a "telopeptidase," in that it efficiently clipped intact molecules of types II and XI collagens at sites just inside their terminal cross-linking hydroxylysine residues. Native molecules of type X collagen were cleaved by stromelysin-1 within their triple helical domains at a COOH-terminal site that reduced the alpha 1(X) chain size by 10 kDa. These findings suggest an important role for stromelysin in the turnover and remodeling of the collagenous matrix of cartilage both normally and in degenerative joint disease.
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Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Matsudaira, P. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61070-1 · Cited by 4,950
Okada, Y., Nagase, H., & Harris, E. D. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67011-5 · Cited by 513
Chin, J. R., Murphy, G., & Werb, Z. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39034-8 · Cited by 495
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes
Murphy, G., Cockett, M. I., Stephens, P. E., Smith, B. J., & Docherty, A. J. P. (1987) · Biochemical Journal · doi:10.1042/bj2480265 · Cited by 464
Comparison of human stromelysin and collagenase by cloning and sequence analysis
Whitham, S. E., Murphy, G., Angel, P., Rahmsdorf, H. J., Smith, B. J., Lyons, A., Harris, T. J. R., Reynolds, J. J., Herrlich, P., & Docherty, A. J. P. (1986) · Biochemical Journal · doi:10.1042/bj2400913 · Cited by 436
MacNaul, K. L., Chartrain, N., Lark, M., Tocci, M. J., & Hutchinson, N. I. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44894-0 · Cited by 399
Self-citationThe collagenase gene family in humans consists of at least four members
Muller, D., Quantin, B., Gesnel, M. C., Millon-Collard, R., Abecassis, J., & Breathnach, R. (1988) · Biochemical Journal · doi:10.1042/bj2530187 · Cited by 365
Matrisian, L. M., Glaichenhaus, N., Gesnel, M. C., & Breathnach, R. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03799.x · Cited by 333
Type IX collagen proteoglycan from cartilage is covalently cross-linked to type II collagen.
van der Rest, M., & Mayne, R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77922-8 · Cited by 268
Cited by
Handa, T., Ishihara, H., Ohshima, H., Osada, R., Tsuji, H., & Obata, K. (1997) · Spine · doi:10.1097/00007632-199705150-00006 · Cited by 310
Flannery, C. R., Lark, M. W., & Sandy, J. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48387-1 · Cited by 270
Self-citationGoda, S., Kato, Y., Domae, E., Hayashi, H., Tani‐Ishii, N., Iida, J., & Ikeo, T. (2015) · International Endodontic Journal · doi:10.1111/iej.12411 · Cited by 27
Metadata
- Authors
- Wu, J. J., Lark, M. W., Chun, L. E., & Eyre, D. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-03
- Volume
- 266
- Issue
- 9
- Pages
- 5625-5628
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1523927558
- Cited by
- 259
- References
- 19
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wu, J. J., Lark, M. W., Chun, L. E., & Eyre, D. R. (1991). Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)67640-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
