The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids
Open accessAbstract
Rates of muscle protein synthesis were measured in vivo in tissues of post-absorptive young rats that were given intravenous infusions of various combinations of insulin and amino acids. In the absence of amino acid infusion, there was a steady rise in muscle protein synthesis with plasma insulin concentration up to 158 mu units/ml, but when a complete amino acids mixtures was included maximal rates were obtained at 20 mu units/ml. The effect of the complete mixture could be reproduced by a mixture of essential amino acids or of branched-chain amino acids, but not by a non-essential mixture, alanine, methionine or glutamine. It is concluded that amino acids, particularly the branched-chain ones, increase the sensitivity of muscle protein synthesis to insulin.
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Citations
Cites
Protein turnover in mammalian tissues and in the whole body
Waterlow, J. C., Garlick, P. J., & Millward, D. J. (1978) · Medical Entomology and Zoology · Cited by 1,227
Self-citationGarlick, P. J., McNurlan, M. A., & Preedy, V. R. (1980) · Biochemical Journal · doi:10.1042/bj1920719 · Cited by 973
Self-citationEffects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.
Fulks, R. M., Li, J. B., & Goldberg, A. L. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42013-9 · Cited by 907
Leucine. A possible regulator of protein turnover in muscle.
Buse, M. G., & Reid, S. S. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108201 · Cited by 743
Influence of amino acid availability on protein turnover in perfused skeletal muscle
Li, J. B., & Jefferson, L. S. (1978) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(78)90103-4 · Cited by 276
The effect of insulin infusion and food intake on muscle protein synthesis in postabsorptive rats
Garlick, P. J., Fern, M., & Preedy, V. R. (1983) · Biochemical Journal · doi:10.1042/bj2100669 · Cited by 265
Self-citationRennie, M. J., Babij, P., Taylor, P. M., Hundal, H. S., Maclennan, P., Watt, P. W., Jepson, M. M., & Millward, D. J. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92617-6 · Cited by 210
Effect of leucine and metabolites of branched chain amino acids on protein turnover in heart.
Chua, B., Siehl, D. L., & Morgan, H. E. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86898-9 · Cited by 186
Failure of leucine to stimulate protein synthesis in vivo
McNurlan, M. A., Fern, E. B., & Garlick, P. J. (1982) · Biochemical Journal · doi:10.1042/bj2040831 · Cited by 149
Self-citationPreedy, V. R., & Garlick, P. J. (1986) · Bioscience Reports · doi:10.1007/bf01115004 · Cited by 116
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Cited by
Min, B. R., Barry, T. N., Attwood, G. T., & McNabb, W. C. (2003) · Animal Feed Science and Technology · doi:10.1016/s0377-8401(03)00041-5 · Cited by 1,051
ISSN exercise & sports nutrition review update: research & recommendations
Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846
Kimball, S. R., & Jefferson, L. S. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.227s · Cited by 631
Metadata
- Authors
- Garlick, P. J., & Grant, I.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1988-09-01
- Volume
- 254
- Issue
- 2
- Pages
- 579-584
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2239103220
- Cited by
- 285
- References
- 19
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Garlick, P. J., & Grant, I. (1988). Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched-chain amino acids. Biochemical Journal. https://doi.org/10.1042/bj2540579
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
