The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Human macrophages convert l-tryptophan into the neurotoxin quinolinic acid
Open accessAbstract
Substantial increases in the concentrations of the excitotoxin and N-methyl-D-aspartate-receptor agonist quinolinic acid (QUIN) occur in human patients and non-human primates with inflammatory diseases. Such increases were postulated to be secondary to induction of indoleamine 2,3-dioxygenase in inflammatory cells, particularly macrophages, by interferon-gamma. To test this hypothesis, human peripheral-blood macrophages were incubated with L-[13C6]tryptophan in the absence or presence of interferon-gamma. [13C6]QUIN was quantified by gas chromatography and electron-capture negative-chemical-ionization mass spectrometry. [13C6]QUIN was detected in the incubation medium of both unstimulated and stimulated cultures. Exposure to interferon-gamma substantially increased the accumulation of [13C6]QUIN in a dose- and time-dependent manner. The QUIN concentrations achieved exceeded those reported in both cerebrospinal fluid and blood of patients and of non-human primates with inflammatory diseases. Macrophages stimulated with interferon-gamma may be an important source of accelerated L-tryptophan conversion into QUIN in inflammatory diseases.
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Cites
Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain
Schwarcz, R., Whetsell, W. O., & Mangano, R. M. (1983) · Science · doi:10.1126/science.6849138 · Cited by 1,263
Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism
Taylor, M. W., & Feng, G. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.11.1907934 · Cited by 1,060
HEYES, M. P., SAITO, K., CROWLEY, J. S., DAVIS, L. E., DEMITRACK, M. A., DER, M., DILLING, L. A., ELIA, J., KRUESI, M. J. P., LACKNER, A., et al. (1992) · Brain · doi:10.1093/brain/115.5.1249 · Cited by 680
Self-citationSecretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1
Giulian, D., Vaca, K., & Noonan, C. A. (1990) · Science · doi:10.1126/science.2148832 · Cited by 620
Heyes, M. P., Brew, B. J., Martin, A., Price, R. W., Salazar, A. M., Sidtis, J. J., Yergey, J. A., Mouradian, M. M., Sadler, A. E., Keilp, J., et al. (1991) · Annals of Neurology · doi:10.1002/ana.410290215 · Cited by 571
Self-citationEffects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse
Saito, K., Markey, S. P., & Heyes, M. P. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90467-g · Cited by 199
Self-citationA mechanism for increased quinolinic acid formation following acute systemic immune stimulation
Saito, K., Crowley, J. S., Markey, S. P., & Heyes, M. P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82284-0 · Cited by 184
Self-citationWhetsell, W. O., & Schwarcz, R. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90609-5 · Cited by 175
Heyes, M. P., Saito, K., Major, E. O., Milstien, S., Markey, S. P., & Vickers, J. H. (1993) · Brain · doi:10.1093/brain/116.6.1425 · Cited by 170
Self-citationSaito, K., Nowak, T. S., Markey, S. P., & Heyes, M. P. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb05836.x · Cited by 166
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A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Kynurenines in the mammalian brain: when physiology meets pathology
Schwarcz, R., Bruno, J. P., Muchowski, P. J., & Wu, H.-Q. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3257 · Cited by 1,530
A Meta-Analysis of Cytokines in Alzheimer's Disease
Swardfager, W., Lanctôt, K., Rothenburg, L., Wong, A., Cappell, J., & Herrmann, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.012 · Cited by 1,108
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723
Quinolinic acid, the inescapable neurotoxin
Guillemin, G. J. (2012) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08485.x · Cited by 595
Metadata
- Authors
- Heyes, M. P., Saito, K., & Markey, S. P.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1992-05-01
- Volume
- 283
- Issue
- 3
- Pages
- 633-635
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1833773432
- Cited by
- 447
- References
- 24
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- green
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