The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
l-arginine transport is increased in macrophages generating nitric oxide
Open accessAbstract
Transport of L-arginine and nitrite production were examined in the murine macrophage cell line J774. Bacterial lipopolysaccharide (LPS) induced a dose- and time-dependent stimulation of nitrite production, which was further increased in the presence of interferon-gamma. Nitrite synthesis was absolutely dependent on extracellular L-arginine and inhibited in the presence of L-lysine or L-ornithine. In unactivated J774 cells L-arginine transport was saturable, with an apparent Km of 0.14 +/- 0.04 mM and Vmax. of 15 +/- 2 nmol/h per 10(6) cells. LPS (1 microgram/ml) induced a time-dependent stimulation of L-arginine transport, and after 24 h the Vmax. increased to 34 +/- 2 nmol/h per 10(6) cells. These findings indicate that activation of J774 cells with LPS produces an increase in both L-arginine transport and nitrite synthesis. The elevated rate of L-arginine transport in activated J774 cells may provide a mechanism for sustained substrate supply during enhanced utilization of L-arginine for the generation of NO.
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Cites
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126
Cited by
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Minghetti, L. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00052-x · Cited by 567
Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells
Mann, G. E., Yudilevich, D. L., & Sobrevia, L. (2003) · Physiological Reviews · doi:10.1152/physrev.00022.2002 · Cited by 430
Self-citationComplement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity
Napier, B. A., Brubaker, S. W., Sweeney, T. E., Monette, P., Rothmeier, G. H., Gertsvolf, N. A., Puschnik, A., Carette, J. E., Khatri, P., & Monack, D. M. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20160027 · Cited by 149
Barton, C. H., Whitehead, S. H., & Blackwell, J. M. (1995) · Molecular Medicine · doi:10.1007/bf03401551 · Cited by 129
Metadata
- Authors
- Bogle, R. G., Baydoun, A. R., Pearson, J. D., Moncada, S., & Mann, G. E.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1992-05-15
- Volume
- 284
- Issue
- 1
- Pages
- 15-18
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1212704
- Cited by
- 235
- References
- 2
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bogle, R. G., Baydoun, A. R., Pearson, J. D., Moncada, S., & Mann, G. E. (1992). l-arginine transport is increased in macrophages generating nitric oxide. Biochemical Journal. https://doi.org/10.1042/bj2840015
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