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Evolutionary families of peptidases
Open accessAbstract
The available amino acid sequences of peptidases have been examined, and the enzymes have been allocated to evolutionary families. Some of the families can be grouped together in ‘clans’ that show signs of distant relationship, but nevertheless, it appears that there may be as many as 60 evolutionary lines of peptidases with separate origins. Some of these contain members with quite diverse peptidase activities, and yet there are some striking examples of convergence. We suggest that the classification by families could be used as an extension of the current classification by catalytic type.
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Cited by
Rawlings, N. D., Barrett, A. J., Thomas, P. D., Huang, X., Bateman, A., & Finn, R. D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1134 · Cited by 1,749
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Rawlings, N. D., Barrett, A. J., & Bateman, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr987 · Cited by 1,544
Self-citationComplete Structure of the 11-Subunit Bovine Mitochondrial Cytochrome bc 1 Complex
Iwata, S., Lee, J. W., Okada, K., Lee, J. K., Iwata, M., Rasmussen, B., Link, T. A., Ramaswamy, S., & Jap, B. K. (1998) · Science · doi:10.1126/science.281.5373.64 · Cited by 1,253
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Metadata
- Authors
- Rawlings, N. D., & Barrett, A. J.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1993-02-15
- Volume
- 290
- Issue
- 1
- Pages
- 205-218
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1952065778
- Cited by
- 923
- References
- 0
- FWCI
- 16.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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