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Cited by 645

The DOI matches its Crossref record.

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

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Eichholtz, T, Jalink, K, Fahrenfort, I, Moolenaar, W H·1993·Biochemical Journal
DOI 10.1042/bj2910677
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Abstract

Lysophosphatidic acid (LPA) is a water-soluble phospholipid with hormone-like and growth-factor-like activities. LPA activates a putative G-protein-coupled receptor in responsive cells, but the natural source of exogenous LPA is unknown. Here we show that LPA is present in mammalian serum in an active form (bound to albumin) at concentrations of 1-5 microM, but is not detectable in platelet-poor plasma, suggesting that LPA is produced during blood clotting. We find that thrombin activation of platelets prelabelled with [32P]Pi results in the rapid release of newly formed [32P]LPA into the extracellular environment. We conclude that LPA is a novel platelet-derived lipid mediator that may play a role in inflammatory and proliferative responses to injury.

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Metadata

Authors
Eichholtz, T., Jalink, K., Fahrenfort, I., & Moolenaar, W. H.
Venue
Biochemical Journal
Publisher
Portland Press Ltd.
Published
1993-05-01
Volume
291
Issue
3
Pages
677-680
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
DOI
10.1042/bj2910677
OpenAlex
W1776576701
Cited by
645
References
0
FWCI
6.62
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The bioactive phospholipid lysophosphatidic acid is released from activated platelets. https://app.cochat.ai/papers/10.1042/bj2910677
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Eichholtz, T., Jalink, K., Fahrenfort, I., & Moolenaar, W. H. (1993). The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochemical Journal. https://doi.org/10.1042/bj2910677

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.