The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Molecular cloning of a rat κ opioid receptor reveals sequence similarities to the μ and δ opioid receptors
Open accessAbstract
By screening a rat brain cDNA library using a cloned mu opioid receptor cDNA as probe, a clone was identified that is very similar to both the mu and delta opioid receptor sequences. Transient expression of this clone in COS-7 cells showed that it encodes a kappa opioid receptor, designated KOR-1, which is capable of high-affinity binding to kappa-selective ligands. Treatment of transfected cell membranes with bremazocine, a kappa-selective agonist, resulted in a 53% decrease in adenylate cyclase activity, indicating that this kappa opioid receptor displays inhibitory coupling to adenylate cyclase. Thus, one member from each of the three opioid receptor types, mu, kappa and delta, has been molecularly cloned. Analysis of sequence similarities among these opioid receptors, as well as between opioid receptors and other G-protein-coupled receptors, revealed regions of sequence conservation that may underlie the ligand-binding and functional specificities of opioid receptors.
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Cites
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Cloning of a Delta Opioid Receptor by Functional Expression
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Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
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Cited by
Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., Gong, J., Schluger, J., Strong, J. A., Leal, S. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9608 · Cited by 1,074
Self-citationWaldhoer, M., Bartlett, S. E., & Whistler, J. L. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073940 · Cited by 740
Mu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y.-X. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 578
Current Research on Opioid Receptor Function
Feng, Y., He, X., Yang, Y., Chao, D., H. Lazarus, L., & Xia, Y. (2012) · Current Drug Targets · doi:10.2174/138945012799201612 · Cited by 329
30 years of dynorphins — New insights on their functions in neuropsychiatric diseases
Schwarzer, C. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.006 · Cited by 289
Metadata
- Authors
- Chen, Y., Mestek, A., Liu, J., & Yu, L.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1993-11-01
- Volume
- 295
- Issue
- 3
- Pages
- 625-628
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W82774609
- Cited by
- 257
- References
- 18
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chen, Y., Mestek, A., Liu, J., & Yu, L. (1993). Molecular cloning of a rat κ opioid receptor reveals sequence similarities to the μ and δ opioid receptors. Biochemical Journal. https://doi.org/10.1042/bj2950625
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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