The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1
Open accessAbstract
The G-protein-coupled central cannabinoid receptor (CB1) has been shown to be functionally associated with several biological responses including inhibition of adenylate cyclase, modulation of ion channels and induction of the immediate-early gene Krox-24. Using stably transfected Chinese Hamster Ovary cells expressing human CB1 we show here that cannabinoid treatment induces both phosphorylation and activation of mitogen-activated protein (MAP) kinases, and that these effects are inhibited by SR 141716A, a selective CB1 antagonist. The two p42 and p44 kDa MAP kinases are activated in a time- and dose-dependent manner. The rank order of potency for the activation of MAP kinases with various cannabinoid agonists is CP-55940 > delta 9-tetrahydrocannabinol > WIN 55212.2, in agreement with the pharmacological profile of CB1. The activation of MAP kinases is blocked by pertussis toxin but not by treatment with hydrolysis-resistant cyclic AMP analogues. This suggests that the signal transduction pathway between CB1 and MAP kinases involves a pertussis-toxin-sensitive GTP-binding protein and is independent of cyclic AMP metabolism. This coupling of CB1 subtype and mitogenic signal pathway, also observed in the human astrocytoma cell line U373 MG, may explain the mechanism of action underlying cannabinoid-induced Krox-24 induction.
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Cites
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SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
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Self-citationRegulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways
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International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
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Self-citationEndocannabinoid-Mediated Control of Synaptic Transmission
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SR 144528, the First Potent and Selective Antagonist of the CB2 Cannabinoid Receptor
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Metadata
- Authors
- Bouaboula, M., Poinot-Chazel, C., Bourrié, B., Canat, X., Calandra, B., Rinaldi-Carmona, M., Le Fur, G., & Casellas, P.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1995-12-01
- Volume
- 312
- Issue
- 2
- Pages
- 637-641
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1812356957
- Cited by
- 543
- References
- 29
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bouaboula, M., Poinot-Chazel, C., Bourrié, B., Canat, X., Calandra, B., Rinaldi-Carmona, M., Le Fur, G., & Casellas, P. (1995). Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. Biochemical Journal. https://doi.org/10.1042/bj3120637
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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