The DOI matches its Crossref record; 44 of the 51 references it cites were found in a registry or an index.
Tissue variation in the control of oxidative phosphorylation: implication for mitochondrial diseases
Open accessAbstract
Metabolic control analysis has often been used for quantitative studies of the regulation of mitochondrial oxidative phosphorylations (OXPHOS). The main contribution of this work has been to show that the control of mitochondrial metabolic fluxes can be shared among several steps of the oxidative phosphorylation process, and that this distribution can vary according to the steady state and the tissue. However, these studies do not show whether this observed variation in the OXPHOS control is due to the experimental conditions or to the nature of the mitochondria. To find out if there actually exists a tissue variation in the distribution of OXPHOS control coefficients, we determined the control coefficients of seven OXPHOS complexes on the oxygen-consumption flux in rat mitochondria isolated from five different tissues under identical experimental conditions. Thus in this work, only the nature of the mitochondria can be responsible for any variation detected in the control coefficient values between different tissues. The analysis of control coefficient distribution shows two tissue groups: (i) the muscle and the heart, controlled essentially at the level of the respiratory chain; and (ii) the liver, the kidney and the brain, controlled mainly at the phosphorylation level by ATP synthase and the phosphate carrier. We propose that this variation in control coefficient according to the tissue origin of the mitochondria can explain part of the tissue specificity observed in mitochondrial cytopathies.
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“Control experiments were carried out in the presence of atractyloside (ATR), a substrate of ANT, to ensure that the ADP/ATP exchange was mediated by the ADP/ATP carrier (Atlante et al., 2003; Rossignol et al., 2000; Wanders et al., 1984).”
From Mitochondrial Dysfunction Induced by Sertraline, an Antidepressant Agent (2012) · cites this paper as Rossignol et al., 2000
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Cites
The Respiratory Chain and Oxidative Phosphorylation
Chance, B., & Williams, G. R. (1956) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122624.ch2 · Cited by 2,084
KACSER, H., & Ja, B. (1973) · PubMed · Cited by 1,455
Heinrich, R., & Rapoport, T. A. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03318.x · Cited by 1,400
Diseases of the mitochondrial DNA
Wallace, D. C. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.005523 · Cited by 1,319
THE MOLECULAR BASIS OF DOMINANCE
KACSER, H., & Burns, J. A. (1981) · Genetics · doi:10.1093/genetics/97.3-4.639 · Cited by 1,040
Metabolic control analysis: a survey of its theoretical and experimental development
Fell, D. A. (1992) · Biochemical Journal · doi:10.1042/bj2860313 · Cited by 782
DiMauro, S., Bonilla, E., Zeviani, M., Nakagawa, M., & Vivo, D. C. D. (1985) · Annals of Neurology · doi:10.1002/ana.410170602 · Cited by 703
Quantification of the contribution of various steps to the control of mitochondrial respiration.
Groen, A. K., Wanders, R. J. A., Westerhoff, H. V., van der Meer, R., & Tager, J. M. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81026-8 · Cited by 629
The Metabolism of Rat Brain Mitochondria
Clark, J. B., & Nicklas, W. J. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62854-6 · Cited by 560
Metabolic control theory: A structural approach
Reder, C. (1988) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(88)80073-0 · Cited by 551
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7 of the 51 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Kacser, H. and Burns, J. A. in Rate Control of Biological Processes (1973) (Davies, D. D., ed.), pp. 65-104, Cambridge University Press, Cambridge
- Jumelle-Laclau, M. (1993) Ph.D. Thesis, Universite! Victor Segalen-Bordeaux 2 11
- Morgan-Hughes, J. A. (1986) in Myology (Engel, A. G. and Banker, B. Q., eds.), pp. 1709-1743, McGraw Hill, New York
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Items 201–202 of 202
How does mitochondrial heteroplasmy affect cell proliferation?
Sutton, S. K. (2006) · UC Research Repository (University of Canterbury) · doi:10.26021/9173
Metadata
- Authors
- ROSSIGNOL, R., LETELLIER, T., MALGAT, M., ROCHER, C., & MAZAT, J.-P.
- Affiliations
- Inserm (FR)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2000-03-27
- Volume
- 347
- Issue
- 1
- Pages
- 45-53
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1220929
- OpenAlex
- W2093325321
- Cited by
- 202
- References
- 51
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 11 · 2013: 7 · 2012: 13
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- oxidative phosphorylation, metabolic control analysis, control coefficients, tissue variation, mitochondrial disease, oxygen consumption, ATP synthase, phosphate transporters, electron transport chain, muscle mitochondria, heart mitochondria, liver mitochondria, kidney mitochondria, brain mitochondria
- MeSH terms
- Animals, Antimycin A, Brain, Kidney, Kinetics, Male, Mitochondria, Mitochondria, Heart, Mitochondria, Liver, Mitochondria, Muscle, Organ Specificity, Oxidative Phosphorylation, Oxygen Consumption, Polarography, Rotenone, Rats, Wistar, Mitochondrial Myopathies, Rats
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