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Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
Open accessAbstract
The transcription factor sterol regulatory-element-binding protein-1c (SREBP-1c) plays a major role in the effect of insulin on the transcription of hepatic genes such as glucokinase and fatty acid synthase. We show here in cultured rat hepatocytes that insulin, through activation of the phosphatidylinositol 3-kinase pathway increases the abundance of the precursor form of SREBP-1c in endoplasmic reticulum. This precursor form is then rapidly cleaved, possibly irrespective of the continuous presence of insulin, leading to an increased content of the nuclear mature form of SREBP-1c. Nevertheless, the increased amount of the mature form of SREBP-1c in the nucleus is not a prerequisite for the rapid effect of insulin on the transcription of genes such as glucokinase, suggesting that additional actions of the hormone are involved, such as the activation of the nuclear form of SREBP-1c or of an unidentified SREBP-1c partner.
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Cited by
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Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413
Li, S., Brown, M. S., & Goldstein, J. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914798107 · Cited by 733
Mechanisms of nutritional and hormonal regulation of lipogenesis
Kersten, S. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve071 · Cited by 700
Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents
Di Pino, A., & DeFronzo, R. A. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00141 · Cited by 535
Dentin, R., Pégorier, J.-P., Benhamed, F., Foufelle, F., Ferré, P., Fauveau, V., Magnuson, M. A., Girard, J., & Postic, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312475200 · Cited by 444
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Metadata
- Authors
- AZZOUT-MARNICHE, D., BÉCARD, D., GUICHARD, C., FORETZ, M., FERRÉ, P., & FOUFELLE, F.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2000-08-23
- Volume
- 350
- Issue
- 2
- Pages
- 389-393
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2117716768
- Cited by
- 257
- References
- 0
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- AZZOUT-MARNICHE, D., BÉCARD, D., GUICHARD, C., FORETZ, M., FERRÉ, P., & FOUFELLE, F. (2000). Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochemical Journal. https://doi.org/10.1042/bj3500389
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