Cited by 700Lipid metabolism and biosynthesisCancer, Lipids, and MetabolismLipid metabolism and disorders

Mechanisms of nutritional and hormonal regulation of lipogenesis

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Kersten, Sander·2001·The EMBO Reports

Abstract

Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly. Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids and by fasting. These effects are partly mediated by hormones, which inhibit (growth hormone, leptin) or stimulate (insulin) lipogenesis. Recent research has established that sterol regulatory element binding protein-1 is a critical intermediate in the pro- or anti-lipogenic action of several hormones and nutrients. Another transcription factor implicated in lipogenesis is the peroxisome proliferator activated receptor gamma. Both transcription factors are attractive targets for pharmaceutical intervention of disorders such as hypertriglyceridemia and obesity.

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Crossref · 10.1093/embo-reports/kve071

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Authors
Kersten, S.
Affiliations
Wageningen University & Research (NL)
Corresponding author
Kersten, Sander
Venue
The EMBO Reports
Published
2001-04-01
Volume
2
Issue
4
Pages
282-286
ISSN
  • 1469-221X (ISSN-L)
  • 1469-3178
OpenAlex
W2050509217
Cited by
700
References
54
Citations by year
2026: 17 · 2025: 28 · 2024: 38 · 2023: 30 · 2022: 43 · 2021: 39 · 2020: 34 · 2019: 34 · 2018: 40 · 2017: 26 · 2016: 31 · 2015: 49 · 2014: 38 · 2013: 36 · 2012: 26
FWCI
1.23
Type
journal article
Language
en
Open access
Locations
  • EMBO Reports (publishedVersion)
  • PubMed Central (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • The EMBO Journal
Funders
Koninklijke Nederlandse Akademie van Wetenschappen
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
lipogenesis, lipolysis, fatty acid oxidation, dietary carbohydrates, polyunsaturated fatty acids, fasting, insulin, leptin, growth hormone, SREBP1, PPARγ, transcriptional regulation, hypertriglyceridemia, obesity
MeSH terms
Animals, Diet, DNA-Binding Proteins, Fatty Acids, Humans, Lipids, Models, Biological, Transcription Factors, Transcription, Genetic, Adipocytes, Receptors, Cytoplasmic and Nuclear, CCAAT-Enhancer-Binding Proteins, Hepatocytes, Sterol Regulatory Element Binding Protein 1

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