Mechanisms of nutritional and hormonal regulation of lipogenesis
Open accessAbstract
Fat build-up is determined by the balance between lipogenesis and lipolysis/fatty acid oxidation. In the past few years, our understanding of the nutritional, hormonal and particularly transcriptional regulation of lipogenesis has expanded greatly. Lipogenesis is stimulated by a high carbohydrate diet, whereas it is inhibited by polyunsaturated fatty acids and by fasting. These effects are partly mediated by hormones, which inhibit (growth hormone, leptin) or stimulate (insulin) lipogenesis. Recent research has established that sterol regulatory element binding protein-1 is a critical intermediate in the pro- or anti-lipogenic action of several hormones and nutrients. Another transcription factor implicated in lipogenesis is the peroxisome proliferator activated receptor gamma. Both transcription factors are attractive targets for pharmaceutical intervention of disorders such as hypertriglyceridemia and obesity.
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Glucose inhibits the release of glucagon from pancreatic α-cells.
“In parallel, glucose inhibits the release of glucagon from the pancreatic α‐cells 25, 26.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [25]
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- Authors
- Kersten, S.
- Affiliations
- Wageningen University & Research (NL)
- Corresponding author
- Kersten, Sander
- ORCID
- Kersten, Sander
- Venue
- The EMBO Reports
- Published
- 2001-04-01
- Volume
- 2
- Issue
- 4
- Pages
- 282-286
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC1083868
- OpenAlex
- W2050509217
- Cited by
- 700
- References
- 54
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 38 · 2023: 30 · 2022: 43 · 2021: 39 · 2020: 34 · 2019: 34 · 2018: 40 · 2017: 26 · 2016: 31 · 2015: 49 · 2014: 38 · 2013: 36 · 2012: 26
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- EMBO Reports (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- The EMBO Journal
- Funders
- Koninklijke Nederlandse Akademie van Wetenschappen
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- lipogenesis, lipolysis, fatty acid oxidation, dietary carbohydrates, polyunsaturated fatty acids, fasting, insulin, leptin, growth hormone, SREBP1, PPARγ, transcriptional regulation, hypertriglyceridemia, obesity
- MeSH terms
- Animals, Diet, DNA-Binding Proteins, Fatty Acids, Humans, Lipids, Models, Biological, Transcription Factors, Transcription, Genetic, Adipocytes, Receptors, Cytoplasmic and Nuclear, CCAAT-Enhancer-Binding Proteins, Hepatocytes, Sterol Regulatory Element Binding Protein 1
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