Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage
Open accessAbstract
Mouse embryonic stem (ES) cells are pluripotent cells that differentiate into multiple cell lineages. The commitment of ES cells into the adipocyte lineage is dependent on an early 3-day treatment with all-trans retinoic acid (RA). To characterize the molecular mechanisms underlying this process, we examined the contribution of the extracellular-signal-regulated kinase (ERK) pathway. Treatment of ES cell-derived embryoid bodies with RA resulted in a prolonged activation of the ERK pathway, but not the c-Jun N-terminal kinase, p38 mitogen-activated protein kinase or phosphoinositide 3-kinase pathways. To investigate the role of ERK activation, co-treatment of RA with PD98059, a specific inhibitor of the ERK signalling pathway, prevented both adipocyte formation and expression of the adipogenic markers, adipocyte lipid-binding protein and peroxisome-proliferator-activated receptor γ. Furthermore, we show that ERK activation is required only during RA treatment. PD98059 does not interfere with the commitment of ES cells into other lineages, such as neurogenesis, myogenesis and cardiomyogenesis. As opposed to the controversial role of the ERK pathway in terminal differentiation, our results clearly demonstrate that this pathway is specifically required at an early stage of adipogenesis, corresponding to the RA-dependent commitment of ES cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In neuronal cells, Sertoli cells, and embryonic stem cells, RA instead activates p42/p44 Erk or classical MAPKs.
“However, in neuronal cells, Sertoli cells, and embryonic stem cells, RA instead activates the p42/p44 extracellular signal-regulated kinases (Erk) or classical MAPKs ( 116-122 ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [118]
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,460 · see citing works
Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 4,557 · see citing works
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,533 · see citing works
Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,396 · see citing works
The RXR heterodimers and orphan receptors
Mangelsdorf, D. J., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90200-7 · Cited by 3,165 · see citing works
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Dyk, D. E. V., Pitts, W. J., Earl, R. A., Hobbs, F. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18623 · Cited by 3,016 · see citing works
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., & Saltiel, A. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7686 · Cited by 2,679 · see citing works
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,182 · see citing works
PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081 · see citing works
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
Williams, R. L., Hilton, D. J., Pease, S., Willson, T. A., Stewart, C. L., Gearing, D. P., Wagner, E. F., Metcalf, D., Nicola, N. A., & Gough, N. M. (1988) · Nature · doi:10.1038/336684a0 · Cited by 1,997 · see citing works
PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development
Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,960 · see citing works
Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886 · see citing works
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
Smith, A. G., Heath, J. K., Donaldson, D. D., Wong, G. G., Moreau, J., Stahl, M., & Rogers, D. D. (1988) · Nature · doi:10.1038/336688a0 · Cited by 1,855 · see citing works
Signal Transduction through MAP Kinase Cascades
Lewis, T. S., Shapiro, P. S., & Ahn, N. G. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759 · see citing works
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,342 · see citing works
Embryonic Stem Cells Express Neuronal Properties in Vitro
Bain, G., Kitchens, D. L., Yao, M., Huettner, J. E., & Gottlieb, D. I. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1085 · Cited by 1,168 · see citing works
Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ
Hu, E., Kim, J. B., Sarraf, P., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.274.5295.2100 · Cited by 1,051 · see citing works
Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?
Kastner, P., Mark, M. P., & Chambon, P. (1995) · Cell · doi:10.1016/0092-8674(95)90202-3 · Cited by 989 · see citing works
Jaiswal, R. K., Jaiswal, N., Bruder, S. P., Mbalaviele, G., Marshak, D. R., & Pittenger, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9645 · Cited by 771 · see citing works
Lohnes, D., Mark, M. P., Mendelsohn, C. L., Dollé, P., Dierich, A., Gorry, P., Gansmüller, A., & Chambon, P. (1994) · Development · doi:10.1242/dev.120.10.2723 · Cited by 764 · see citing works
Hu, E., Tontonoz, P., & Spiegelman, B. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9856 · Cited by 658 · see citing works
Function of GATA Transcription Factors in Preadipocyte-Adipocyte Transition
Tong, Q., Dalgin, G., Xu, H., Ting, C.-N., Leiden, J. M., & Hotamışlıgil, G. S. (2000) · Science · doi:10.1126/science.290.5489.134 · Cited by 534 · see citing works
Camp, H. S., & Tafuri, S. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10811 · Cited by 447 · see citing works
Differentiation of embryonic stem cells into adipocytes in vitro
Dani, C., Smith, A. G., Dessolin, S., Leroy, P., Staccini-Lavenant, L., Villageois, P., Darimont, C., & Ailhaud, G. P. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.11.1279 · Cited by 435 · see citing works
Self-citationDicistronic targeting constructs: reporters and modifiers of mammalian gene expression.
Mountford, P. S., Zevnik, B., Düwel, A., Nichols, J., Li, M., Dani, C., Robertson, M., Chambers, I., & Smith, A. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4303 · Cited by 312 · see citing works
Self-citationShao, D., & Lazar, M. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21473 · Cited by 272 · see citing works
Sale, E. M., Atkinson, P. G. P., & Sale, G. J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07046.x · Cited by 261 · see citing works
Induction of Cellular Differentiation by Retinoic Acid in vitro
Rohwedel, J., Guan, K., & Wobus, A. M. (1999) · Cells Tissues Organs · doi:10.1159/000016699 · Cited by 211 · see citing works
CHARACTERIZATION OF FOUR NOVEL EPITHELIAL OVARIAN CANCER CELL LINES
Provencher, D. M., Lounis, H., CHAMPOUX, L., Tetrault, M., Manderson, E. N., Wang, J. C., Eydoux, P., Savoie, R., Tonin, P. N., & Mes‐Masson, A. (2000) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1290/1071-2690(2000)036 · Cited by 179 · see citing works
Bost, F., McKay, R. A., Dean, N. S., & Mercola, D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.33422 · Cited by 171 · see citing works
Self-citationde Mora, J. F., Porrás, A., Ahn, N. G., & Santos, E. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.6068 · Cited by 171 · see citing works
Aubert, J., Dessolin, S., Belmonte, N., Li, M., McKenzie, F. R., Staccini-Lavenant, L., Villageois, P., Barhanin, B., Vernallis, A. B., Smith, A. G., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24965 · Cited by 119 · see citing works
Self-citationDefect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.
Heydrick, S. J., Jullien, D., Gautier, N., Tanti, J., Giorgetti‐Peraldi, S., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116337 · Cited by 112 · see citing works
Self-citationWu, Z., Wu, J., Jacinto, E., & Karin, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.12.7407 · Cited by 105 · see citing works
Rohwedel, J., Guan, K., Zuschratter, W., Jin, S., Ahnert‐Hilger, G., Fürst, D. O., Fässler, R., & Wobus, A. M. (1998) · Developmental Biology · doi:10.1006/dbio.1998.9002 · Cited by 105 · see citing works
Wobus, A. M., Rohwedel, J., Maltsev, V. A., & Hescheler, J. (1994) · Development Genes and Evolution · doi:10.1007/bf00189066 · Cited by 103 · see citing works
Lee, H., Sueoka, N., Hong, W.-K., Mangelsdorf, D. J., Claret, F. X., & Kurie, J. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1973 · Cited by 94 · see citing works
An in vitro Pathway from Embryonic Stem Cells to Neurons and Glia
Gottlieb, D. I., & Huettner, J. E. (1999) · Cells Tissues Organs · doi:10.1159/000016696 · Cited by 83 · see citing works
Embryonic Stem Cell-Derived Adipogenesis
Dani, C. (1999) · Cells Tissues Organs · doi:10.1159/000016697 · Cited by 70 · see citing works
Self-citationJho, E., Davis, R. J., & Malbon, C. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24468 · Cited by 65 · see citing works
Yen, A., Roberson, M. S., & Varvayanis, S. S. (1999) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-999-0063-z · Cited by 55 · see citing works
Ricort, J., Tanti, J., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19814 · Cited by 49 · see citing works
Self-citationHescheler, J., Fleischmann, B. K., Wartenberg, M., Bloch, W., Kolossov, E., Ji, G. J., Addicks, K., & Sauer, H. (1999) · Cells Tissues Organs · doi:10.1159/000016695 · Cited by 45 · see citing works
Agadir, A., Chen, G., Bost, F., Li, Y., Mercola, D., & Zhang, X.-K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29779 · Cited by 39 · see citing works
Self-citationKanungo, J., Potapova, I. A., Malbon, C. C., & Wang, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002747200 · Cited by 34 · see citing works
Molecular genetic approaches to microtubule-associated protein function.
González-Billault, C. E., & Ávila, J. (2000) · PubMed · doi:10.14670/hh-15.1177 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 47 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The role of MAPKs in adipocyte differentiation and obesity
Bost, F., Aouadi, M., Caron, L., & Binétruy, B. (2004) · Biochimie · doi:10.1016/j.biochi.2004.10.018 · Cited by 583 · see citing works
Self-citationPrusty, D., Park, B.-H., Davis, K. E., & Farmer, S. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207776200 · Cited by 529 · see citing works
Mechanism of All- Trans Retinoic Acid Effect on Tumor-Associated Myeloid-Derived Suppressor Cells
Nefedova, Y., Fishman, M., Sherman, S., Wang, X., Beg, A. A., & Gabrilovich, D. I. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2593 · Cited by 428 · see citing works
The complexity of mitogen-activated protein kinases (MAPKs) made simple
Krishna, M., & Narang, H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8170-7 · Cited by 439 · see citing works
Vitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408 · see citing works
Bost, F., Aouadi, M., Caron, L., Even, P. C., Belmonte, N., Prot, M., Dani, C., Hofman, P. M., Pagès, G., Pouysségur, J., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.2.402 · Cited by 351 · see citing works
Self-citationMAPK signalling in cellular metabolism: stress or wellness?
Gehart, H., Kumpf, S., Ittner, A., & Ricci, R. (2010) · EMBO Reports · doi:10.1038/embor.2010.160 · Cited by 327 · see citing works
Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders
Blaner, W. S. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.01.006 · Cited by 287 · see citing works
Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK
Graichen, R., Xu, X., Braam, S. R., Balakrishnan, T., Rahmat, S. N. B., Sieh, S., Soo, S. Y., Tham, S. C., Mummery, C. L., Colman, A., et al. (2007) · Differentiation · doi:10.1111/j.1432-0436.2007.00236.x · Cited by 246 · see citing works
Bonet, M. L., Canas, J. A., Ribot, J., & Palou, A. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.02.022 · Cited by 223 · see citing works
Lipid metabolism in mammalian tissues and its control by retinoic acid
Bonet, M. L., Ribot, J., & Palou, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.001 · Cited by 218 · see citing works
S6K1 Plays a Critical Role in Early Adipocyte Differentiation
Carnevalli, L. S., Masuda, K., Frigerio, F., Bacquer, O. L., Um, S. H., Gandin, V., Topisirović, I., Sonenberg, N., Thomas, G., & Kozma, S. C. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.018 · Cited by 205 · see citing works
Inhibition of p38MAPK Increases Adipogenesis From Embryonic to Adult Stages
Aouadi, M., Laurent, K., Prot, M., MARCHAND‐BRUSTEL, Y. L., Binétruy, B., & Bost, F. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-0963 · Cited by 194 · see citing works
Self-citationTumour necrosis factor alpha: a key regulator of adipose tissue mass
Warne, J. P. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1770351 · Cited by 176 · see citing works
Vitamin A and the regulation of fat reserves
Bonet, M. L., Ribot, J., Felipe, F., & Palou, A. (2003) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-2290-x · Cited by 174 · see citing works
Yang, M., Bian, C., Li, J., Du, Z., Zhou, H., Yang, Z., & Zhao, R. C. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24479 · Cited by 169 · see citing works
Tanabe, Y., Koga, M., Saito, M., Matsunaga, Y., & Nakayama, K. (2004) · Journal of Cell Science · doi:10.1242/jcs.01207 · Cited by 163 · see citing works
Role of MAPKs in development and differentiation: lessons from knockout mice
Aouadi, M., Binétruy, B., Caron, L., MARCHAND‐BRUSTEL, Y. L., & Bost, F. (2006) · Biochimie · doi:10.1016/j.biochi.2006.06.003 · Cited by 158 · see citing works
Self-citationHodges, P. W., James, G., Blomster, L. V., Hall, L., Schmid, A. B., Shu, C. C., Little, C. B., & Melrose, J. (2015) · Spine · doi:10.1097/brs.0000000000000972 · Cited by 150 · see citing works
Kusuyama, J., Bandow, K., Shamoto, M., Kakimoto, K., Ohnishi, T., & Matsuguchi, T. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.546382 · Cited by 148 · see citing works
Ge, Q., Zhang, H., Hou, J., Wan, L., Cheng, W., Wang, X., Dong, D., Chen, C., Xia, J. L., Guo, J., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8059 · Cited by 146 · see citing works
Reduced Expression of FOXC2 and Brown Adipogenic Genes in Human Subjects with Insulin Resistance
Yang, X., Enerbäck, S., & Smith, U. (2003) · Obesity Research · doi:10.1038/oby.2003.163 · Cited by 150 · see citing works
Signaling pathways in retinoid chemoprevention and treatment of cancer
Niles, R. M. (2004) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.05.020 · Cited by 141 · see citing works
Nieden, N. I. Z., Kempka, G., & Ahr, H. J. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.09.019 · Cited by 138 · see citing works
Wang, Z., Zhang, X., Wang, H., Li, Q., & Lou, Y. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.059 · Cited by 132 · see citing works
Main regulatory factors of marbling level in beef cattle
Nguyen, D. V., Cong, O. N., & Malau‐Aduli, A. E. O. (2021) · Veterinary and Animal Science · doi:10.1016/j.vas.2021.100219 · Cited by 128 · see citing works
Fibroblast Growth Factor Receptor-1 Is Essential for In Vitro Cardiomyocyte Development
Dell’Era, P., Ronca, R., Coco, L., Nicoli, S., Metra, M., & Presta, M. (2003) · Circulation Research · doi:10.1161/01.res.0000089460.12061.e1 · Cited by 126 · see citing works
Calcineurin Mediates the Calcium-dependent Inhibition of Adipocyte Differentiation in 3T3-L1 Cells
Neal, J. W., & Clipstone, N. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207913200 · Cited by 116 · see citing works
Aouadi, M., Bost, F., Caron, L., Laurent, K., MARCHAND‐BRUSTEL, Y. L., & Binétruy, B. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0398 · Cited by 115 · see citing works
Self-citationAntonyak, M. A., Miller, A. M., Jansen, J. M., Boehm, J. E., Balkman, C. E., Wakshlag, J. J., Page, R. L., & Cerione, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404976200 · Cited by 110 · see citing works
Binétruy, B., Heasley, L. E., Bost, F., Caron, L., & Aouadi, M. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0612 · Cited by 104 · see citing works
Self-citationTeruel, T., Hernández, R., Benito, M., & Lorenzo, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207200200 · Cited by 97 · see citing works
Nutrigenomic regulation of adipose tissue development — role of retinoic acid: A review
Wang, B., Yang, Q., Harris, C. L., Nelson, M. L., Busboom, J. R., Zhu, M. J., & Du, . (2016) · Meat Science · doi:10.1016/j.meatsci.2016.04.003 · Cited by 96 · see citing works
Muenzner, M., Tuvia, N., Deutschmann, C., Witte, N., Tolkachov, A., Valai, A., Henze, A., Sander, L. E., Raila, J., & Schupp, M. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00221-13 · Cited by 96 · see citing works
Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases
Kassouf, T., & Sumara, G. (2020) · Biomolecules · doi:10.3390/biom10091256 · Cited by 94 · see citing works
Hormone‐sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL
Ström, K., Gundersen, T. E., Hansson, O., Lucas, S., Fernandez, C., Blomhoff, R., & Holm, C. (2009) · The FASEB Journal · doi:10.1096/fj.08-120923 · Cited by 91 · see citing works
p38MAP Kinase activity is required for human primary adipocyte differentiation
Aouadi, M., Jager, J., Laurent, K., Gonzalez, T., Cormont, M., Binétruy, B., MARCHAND‐BRUSTEL, Y. L., Tanti, J., & Bost, F. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.10.064 · Cited by 84 · see citing works
Self-citationμ- and κ-Opioids Induce the Differentiation of Embryonic Stem Cells to Neural Progenitors
Kim, E., Clark, A. L., Kiss, A., Hahn, J. W., Wesselschmidt, R. L., Coscia, C. J., & Belcheva, M. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603862200 · Cited by 84 · see citing works
All-Trans Retinoic Acid Increases Oxidative Metabolism in Mature Adipocytes
Mercader, J., Madsen, L., Felipe, F., Palou, A., Kristiansen, K., & Bonet, M. L. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000110717 · Cited by 84 · see citing works
Shoham, N., Gottlieb, R., Sharabani‐Yosef, O., Zaretsky, U., Benayahu, D., & Gefen, A. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00167.2011 · Cited by 83 · see citing works
Tocotrienol Suppresses Adipocyte Differentiation and Akt Phosphorylation in 3T3-L1 Preadipocytes
Uto‐Kondo, H., Ohmori, R., Kiyose, C., Kishimoto, Y., Saito, H., Igarashi, O., & Kondo, K. N. (2008) · Journal of Nutrition · doi:10.3945/jn.108.096131 · Cited by 81 · see citing works
Bonet, M. L., Ribot, J., Galmés, S., Serra, F. A., & Palou, A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158676 · Cited by 82 · see citing works
The rhythm of retinoids in the brain
Ransom, J., Morgan, P. J., McCaffery, P. J. A., & Stoney, P. N. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12620 · Cited by 83 · see citing works
Carotenoids in Adipose Tissue Biology and Obesity
Bonet, M. L., Canas, J. A., Ribot, J., & Palou, A. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-39126-7_15 · Cited by 78 · see citing works
Gupta, P., Ho, P.-C., Huq, M. M., Ha, S. G., Park, S. W., Khan, A. A., Tsai, N.-P., & Wei, L.-N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710561105 · Cited by 74 · see citing works
Liu, Q., Cen, L., Zhou, H., Yin, S., Liu, G., Liu, W., Cao, Y., & Cui, L. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0175 · Cited by 72 · see citing works
Plymate, S. R., Haugk, K. H., Sprenger, C. C. T., Nelson, P. S., Tennant, M. K., Zhang, Y., Oberley, L. W., Zhong, W., Drivdahl, R. H., & Oberley, T. D. (2003) · Oncogene · doi:10.1038/sj.onc.1206210 · Cited by 72 · see citing works
CXCL3 positively regulates adipogenic differentiation
Kusuyama, J., Komorizono, A., Bandow, K., Ohnishi, T., & Matsuguchi, T. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m067207 · Cited by 70 · see citing works
Lü, J., Tan, L., Li, P., Gao, H., Fang, B., Ye, S., Geng, Z., Zheng, P., & Song, H. (2009) · BMC Cell Biology · doi:10.1186/1471-2121-10-57 · Cited by 65 · see citing works
Chang, E.-J., Ha, J., Huang, H., Kim, H. J., Woo, J. H., Lee, Y., Lee, Z. H., Kim, J. H., & Kim, H. (2008) · Journal of Cell Science · doi:10.1242/jcs.028217 · Cited by 63 · see citing works
Murali, G., Desouza, C. V., Clevenger, M. E., Ramalingam, R. K., & Saraswathi, V. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.10.002 · Cited by 57 · see citing works
Kwon, O., Pyo, H. K., Oh, Y. J., Han, J. H., Lee, S. R., Chung, J. H., Eun, H. C., & Kim, K. H. (2007) · Journal of Korean Medical Science · doi:10.3346/jkms.2007.22.2.283 · Cited by 56 · see citing works
Gwon, S. Y., Ahn, J. Y., Jung, C. H., Moon, B. K., & Ha, T. Y. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-207 · Cited by 56 · see citing works
Qing-chuan, L., Li, Y., Qin, Y., Quarles, L. D., Xu, K., Li, R., Zhou, H., & Xiao, Z. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21753 · Cited by 53 · see citing works
Emerging Importance of Phytochemicals in Regulation of Stem Cells Fate via Signaling Pathways
Dadashpour, M., Pilehvar‐Soltanahmadi, Y., Zarghami, N., Firouzi‐Amandi, A., Pourhassan‐Moghaddam, M., & Nouri, M. (2017) · Phytotherapy Research · doi:10.1002/ptr.5908 · Cited by 52 · see citing works
All-trans Retinoic Acid as a Versatile Cytosolic Signal Modulator Mediated by CRABP1
Nagpal, I., & Wei, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153610 · Cited by 51 · see citing works
Antonyak, M. A., McNeill, C. J., Wakshlag, J. J., Boehm, J. E., & Cerione, R. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300037200 · Cited by 49 · see citing works
Fricke, K., Heitland, A., & Maronde, E. (2004) · Endocrinology · doi:10.1210/en.2004-0803 · Cited by 49 · see citing works
Wu, L., Cai, X., Dong, H., Wei, J., Huang, Y., Yang, X., Wu, Y., & Lin, Y. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00709.x · Cited by 47 · see citing works
Heesch, S., Schlee, C., Neumann, M., Stroux, A., Kühnl, A., Schwartz, S., Haferlach, T., Goekbuget, N., Hoelzer, D. T., THIEL, E., et al. (2010) · Leukemia · doi:10.1038/leu.2010.130 · Cited by 46 · see citing works
Chen, W., Jia, W., Wang, K., Zhou, Q., Leng, Y., Duan, T., & Kang, J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.01.078 · Cited by 46 · see citing works
The Role of Pref-1 during Adipogenic Differentiation: An Overview of Suggested Mechanisms
da Silva, C., Durandt, C., Kallmeyer, K., Ambele, M. A., & Pepper, M. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114104 · Cited by 47 · see citing works
ARAUJO, E. P. D., de Souza, C. T., Gasparetti, A. L., Ueno, M., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2004) · Endocrinology · doi:10.1210/en.2004-0778 · Cited by 46 · see citing works
Promyelocytic Leukemia Protein in Retinoic Acid-Induced Chromatin Remodeling of Oct4 Gene Promoter
Chuang, Y.-S., Huang, W.-H., Park, S. W., Persaud, S. D., Hung, C.-H., Ho, P., & Wei, L. (2011) · Stem Cells · doi:10.1002/stem.623 · Cited by 44 · see citing works
Phytochemical Regulation of UDP-Glucuronosyltransferases: Implications for Cancer Prevention
Saracino, M. R., & Lampe, J. W. (2007) · Nutrition and Cancer · doi:10.1080/01635580701458178 · Cited by 44 · see citing works
Peng, D. Q., Smith, S. B., & Lee, H. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00558-2 · Cited by 43 · see citing works
O’Carroll, S. J., Mitchell, M. D., Faenza, I., Cocco, L., & Gilmour, R. S. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.02.002 · Cited by 43 · see citing works
Calcium-Sensing Receptor Expression in Human Adipocytes
Cifuentes, M., Cecilia Albala, B., & Rojas, C. (2005) · Endocrinology · doi:10.1210/en.2004-1281 · Cited by 42 · see citing works
Retinoic acid inhibits adipogenesis via activation of Wnt signaling pathway in 3T3-L1 preadipocytes
Kim, D., Choi, H., Park, A., Shin, S.-M., Bae, K., Lee, S. C., Kim, I., & Kim, W. K. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.095 · Cited by 41 · see citing works
Caron, L., Bost, F., Prot, M., Hofman, P. M., & Binétruy, B. (2005) · Oncogene · doi:10.1038/sj.onc.1208781 · Cited by 41 · see citing works
Self-citationPettersson, F., Couture, M.-C., Hanna, N., & Miller, W. H. (2004) · Oncogene · doi:10.1038/sj.onc.1207956 · Cited by 41 · see citing works
Vitamin A supplementation in early life affects later response to an obesogenic diet in rats
Granados, N., Amengual, J., Ribot, J., Mušinović, H., Ceresi, E., Lintig, J. V., Palou, A., & Bonet, M. L. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.190 · Cited by 40 · see citing works
Wang, Y., Liu, Y., Fan, Z., Liu, D., Wang, F., & Zhou, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184182 · Cited by 40 · see citing works
Signaling Pathways and Gene Regulatory Networks in Cardiomyocyte Differentiation
Parikh, A., Wu, J., Blanton, R. M., & Tzanakakis, E. S. (2015) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2014.0662 · Cited by 41 · see citing works
Differentiation of embryonic stem cells for pharmacological studies on adipose cells
Phillips, B. W., Vernochet, C., & Dani, C. (2003) · Pharmacological Research · doi:10.1016/s1043-6618(03)00035-5 · Cited by 39 · see citing works
Self-citationRARγ acts as a tumor suppressor in mouse keratinocytes
Chen, C. F., Goyette, P., & Lohnes, D. (2004) · Oncogene · doi:10.1038/sj.onc.1207682 · Cited by 39 · see citing works
Hu, X., Lu, J., & Feng, L. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02594.x · Cited by 38 · see citing works
A p38mapk-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells
Hadjal, Y., Hadadeh, O., Yazidi, C., Barruet, E., & Binétruy, B. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.246 · Cited by 34 · see citing works
Self-citationMonteiro, M. C., Wdziekonski, B., Villageois, P., Vernochet, C., Iehlé, C., Billon, N., & Dani, C. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0154 · Cited by 33 · see citing works
Self-citationRetinol and retinoic acid increase MMP-2 activity by different pathways in cultured Sertoli cells
Dalmolin, R. J. S., Zanotto‐Filho, A., de Oliveira, R. B., Duarte, R. F., Pasquali, M. A. D. B., & Moreira, J. C. F. (2007) · Free Radical Research · doi:10.1080/10715760701717427 · Cited by 33 · see citing works
Ko, J., Yun, C., Lee, J., Kim, J., & Kim, I. S. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.15 · Cited by 33 · see citing works
Lee, J. S., Park, J., Kwon, I. K., & Lim, J. Y. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.042 · Cited by 32 · see citing works
Enhanced osteogenesis by collagen‐binding peptide from bone sialoprotein in vitro and in vivo
Choi, Y. J., Lee, J., Chung, C., & Park, Y. J. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34356 · Cited by 32 · see citing works
Kapoor, A., Wang, B., Hsu, W., Chang, M., Liang, S., & Liao, Y.-F. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400039s · Cited by 32 · see citing works
LIJNEN, H. R., Christiaens, V., & Scroyen, L. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.178046 · Cited by 32 · see citing works
Zhu, X., Wang, W., Zhang, X., Bai, J., Chen, G., Li, L., & Li, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143255 · Cited by 32 · see citing works
Differential DNA Methylation Status Between Human Preadipocytes and Mature Adipocytes
Zhu, J., Xia, L., Ji, C., Zhang, C., Zhu, G.-Z., Shi, C., Chen, L., Qin, D., & Guo, X. (2012) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-012-9336-3 · Cited by 32 · see citing works
The immunomodulatory role of all-trans retinoic acid in tumor microenvironment
Bi, G., Liang, J., Bian, Y., Shan, G., Besskaya, V., Wang, Q., & Zhan, C. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00860-x · Cited by 32 · see citing works
Takeno, A., Kanazawa, I., Notsu, M., Tanaka, K., & Sugimoto, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061772 · Cited by 31 · see citing works
Hughes, P., Zhao, Y., Chandraratna, R. A. S., & Brown, G. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20579 · Cited by 29 · see citing works
Kambhampati, S., Verma, A., Li, Y., Parmar, S., Sassano, A., & Platanias, L. (2004) · Leukemia & Lymphoma · doi:10.1080/10428190410001722053 · Cited by 29 · see citing works
Barruet, E., Hadadeh, O., Peiretti, F., Renault, V. M., Hadjal, Y., Bernot, D., Tournaire, R., Négre, D., Juhan-Vague, I., Alessi, M., et al. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0213 · Cited by 27 · see citing works
Self-citationRedonnet, A., Ferrand, C., Bairras, C., Higueret, P., Nöel-Suberville, C., Cassand, P., & Atgié, C. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508967568 · Cited by 27 · see citing works
Han, R., Kitlinska, J. B., Munday, W. R., Gallicano, G. I., & Żukowska, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036609 · Cited by 27 · see citing works
Effects of accumulation of lipid droplets on load transfer between and within adipocytes
Frank, M. B.-O., Shoham, N., Benayahu, D., & Gefen, A. (2014) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-014-0582-8 · Cited by 27 · see citing works
A screen of suitable inducers for germline differentiation of chicken embryonic stem cells
Shi, Q., Sun, M., Zhang, Z.-T., Zhang, Y., Elsayed, A. K., Zhang, L., Huang, X., & Li, B. (2014) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2014.04.002 · Cited by 26 · see citing works
From mice to men – mouse models in obesity research: What can we learn?
Scroyen, I., Hemmeryckx, B., & LIJNEN, H. R. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-11-0873 · Cited by 25 · see citing works
Lin, Y.-W., Park, S. W., Lin, Y., Burton, F. H., & Wei, L. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0379-z · Cited by 25 · see citing works
Pasquali, D., Pierantoni, G., Fusco, A., Staibano, S., Colantuoni, V., Bellis, A. D., Bellastella, A., & Sinisi, A. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0330133 · Cited by 26 · see citing works
Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation
Hocine, T., Blaise, S. A., Hachet, C., Guillot, A., Sartelet, H., Maurice, P., Bennasroune, A., Martiny, L., Duca, L., Romier, B., et al. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-020-00755-z · Cited by 24 · see citing works
- Authors
- BOST, F., CARON, L., MARCHETTI, I., DANI, C., MARCHAND-BRUSTEL, Y. L., & BINÉTRUY, B.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- INSERM E9911 and IFR50, Faculté de Médecine, Université de Nice Sophia Antipolis, Avenue de Valombrose, Nice 06107, France
- Corresponding author
- CARON, Leslie
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2002-01-25
- Volume
- 361
- Issue
- 3
- Pages
- 621-627
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1222345
- OpenAlex
- W1963496112
- Cited by
- 184
- References
- 47
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 2 · 2017: 11 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 15 · 2012: 13
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Servier
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- retinoic acid, ERK signaling, embryonic stem cells, adipogenesis, lineage commitment, PD98059, embryoid bodies, PPARγ, adipocyte lipid-binding protein, MAPK signaling, pluripotency
- MeSH terms
- Animals, Butadienes, Embryo, Mammalian, Enzyme Activation, Enzyme Inhibitors, Flavonoids, Imidazoles, Myocardium, Neurons, Nitriles, Protein Binding, Pyridines, RNA, Stem Cells, Time Factors, Transcription Factors, Tretinoin, Signal Transduction, Adipocytes, Receptors, Cytoplasmic and Nuclear, Cell Lineage, Phosphatidylinositol 3-Kinases, Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review