Anti-androgenicity of flutamide and its metabolite Sch 16423.

NERI, RUDOLPH; PEETS, EDWIN; WATNICK, ARTHUR

doi:10.1042/bst0070565

Cited by 72Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsHormonal and reproductive studies

Anti-androgenicity of flutamide and its metabolite Sch 16423.

NERI, RUDOLPH, PEETS, EDWIN, WATNICK, ARTHUR·1979·Biochemical Society Transactions

DOI 10.1042/bst0070565

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Conference Article| June 01 1979 Anti-Androgenicity of Flutamide and its Metabolite Sch 16423 RUDOLPH NERI; RUDOLPH NERI 1Schering Research Division, Bloomfield, NJ 07003 U.S.A. Search for other works by this author on: This Site PubMed Google Scholar EDWIN PEETS; EDWIN PEETS 1Schering Research Division, Bloomfield, NJ 07003 U.S.A. Search for other works by this author on: This Site PubMed Google Scholar ARTHUR WATNICK ARTHUR WATNICK 1Schering Research Division, Bloomfield, NJ 07003 U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1979 Biochemical Society1979 Biochem Soc Trans (1979) 7 (3): 565–569. https://doi.org/10.1042/bst0070565 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation RUDOLPH NERI, EDWIN PEETS, ARTHUR WATNICK; Anti-Androgenicity of Flutamide and its Metabolite Sch 16423. Biochem Soc Trans 1 June 1979; 7 (3): 565–569. doi: https://doi.org/10.1042/bst0070565 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1979 Biochemical Society1979 Article PDF first page preview Close Modal You do not currently have access to this content.

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The antiandrogen OH-flutamide competitively reversed the effect of DHT and 4-dione with an apparent dissociation constant (Ki, ~110 nM) consistent with its known affinity for the AR.
“the antiandrogen OH-flutamide competitively reversed the effect of DHT and 4-dione with an apparent dissociation constant (K i , ϳ110 nm) consistent with its known affinity for the AR (226,227).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [226]
The inhibitory effect of DHT on ER content was competitively reversed by the antiandrogen hydroxyflutamide.
“Moreover, the inhibitory effect of DHT on ER content was competitively reversed by the antiandrogen hydroxyflutamide (226,227).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [226]
The addition of hydroxyflutamide competitively reversed the inhibition of [3H]E2 specific uptake by DHT.
“The addition of hydroxyflutamide, a nonsteroidal antiandrogen devoid of agonistic activity and with no significant affinity for receptors other than the AR (226, 227) competitively reversed inhibition of [ 3 H]E 2 specific uptake by DHT.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [226]

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Authors: NERI, R., PEETS, E., & WATNICK, A.
Affiliations: Schering Research Division, Bloomfield, NJ 07003 U.S.A.
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 1979-06-01
Volume: 7
Issue: 3
Pages: 565-569
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst0070565
OpenAlex: W2403966502
Cited by: 72
References: 0
Citations by year: 2026: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2014: 1 · 2013: 2 · 2012: 2
FWCI: 0.70
Type: journal article
Language: en
Open access: closed
Locations: Biochemical Society Transactions (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: flutamide, androgen receptor binding, androgen antagonists, drug metabolism
MeSH terms: Anilides, Animals, Castration, Flutamide, Male, Prostate, Receptors, Androgen, Seminal Vesicles, Dihydrotestosterone, Structure-Activity Relationship, Testosterone, Rats

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Anti-androgenicity of flutamide and its metabolite Sch 16423.

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