Physiological roles of PKB/Akt isoforms in development and disease

Cited by (323)

Items 101–200 of 323

1. Brown fat organogenesis and maintenance requires AKT1 and AKT2
   Joan Sánchez-Gurmaches, Camila Martínez Calejman, Su Myung Jung, Huawei Li, David A. Guertin · 2019 · Molecular Metabolism
2. Temporal Changes in Myocardial Salvage Kinases During Reperfusion Following Ischemia: Studies Involving the Cardioprotective Adipocytokine Apelin
   Christopher Smith, Michaela M. Mocanu, Jonathan Peter Bowen, Abigail M. Wynne, James C. Simpkin, Richard A. Dixon, Michael B. Cooper, Derek M. Yellon · 2007 · Cardiovascular Drugs and Therapy
3. Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation
   Véronique Nogueira, Krushna Chandra Patra, Nissim Hay · 2018 · eLife
4. Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling
   Felicitas Bossler, Bianca J. Kuhn, Thomas Günther, Stephen Krämer, Prajakta Khalkar, Svenja Adrian, Claudia Lohrey, Angela Holzer, Mitsugu Shimobayashi, Matthias Dürst et al. · 2019 · mBio
5. Phosphoinositide 3‐kinase‐regulated adapters in lymphocyte activation
   Tingting Zhang, Hongzhao Li, Samuel Cheung, Jennifer L. Costantini, Sen Hou, Monther M Al-Alwan, Aaron J. Marshall · 2009 · Immunological Reviews
6. Overexpression and activation of Akt2 protein in oral squamous cell carcinoma
   Anak Iamaroon, Suttichai Krisanaprakornkit · 2009 · Oral Oncology
7. PDK1–Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex
   Yasuhiro Itoh, Maiko Higuchi, Koji Oishi, Yusuke Kishi, Tomohiko Okazaki, Hiroshi Sakai, Takaki Miyata, Kazunori Nakajima, Yukiko Gotoh · 2016 · Proceedings of the National Academy of Sciences
8. Role of Akt Isoforms Controlling Cancer Stem Cell Survival, Phenotype and Self-Renewal
   Sergio Rivas-Muñoz, Carla Gómez-Oro, Inés M. Antón, Francisco G. Wandosell · 2018 · Biomedicines
9. Syk Activation of Phosphatidylinositol 3-Kinase/Akt Prevents HtrA2-dependent Loss of X-linked Inhibitor of Apoptosis Protein (XIAP) to Promote Survival of Epstein-Barr Virus+ (EBV+) B Cell Lymphomas
   Olivia L. Hatton, Linda Phillips, Maria Vaysberg, Jordan Hurwich, Sheri M. Krams, Olivia M. Martinez · 2011 · Journal of Biological Chemistry
10. The rise and fall of insulin signaling in Alzheimer’s disease
    Belal Chami, Ariah J. Steel, Suzanne M. de la Monte, Greg Trevor Sutherland · 2016 · Metabolic Brain Disease
11. Methylthioadenosine phosphorylase and activated insulin‐like growth factor‐1 receptor/insulin receptor: potential therapeutic targets in chordoma
    Josh Sommer, Doha M. Itani, Kelly C. Homlar, Vicki Leigh Keedy, Jennifer L. Halpern, Ginger E. Holt, Herbert S. Schwartz, Cheryl M. Coffin, Michael J. Kelley, Justin Cates · 2009 · The Journal of Pathology
12. A‐type lamins and signaling: The PI 3‐kinase/Akt pathway moves forward
    Sandra Marmiroli, Jessika Bertacchini, Francesca Beretti, Vittoria Cenni, Marianna Guida, Anto De Pol, Nadir M. Maraldi, Giovanna Lattanzi · 2009 · Journal of Cellular Physiology
13. The interplay between the PI3K / AKT pathway and circadian clock in physiologic and cancer‐related pathologic conditions
    Mohammad Rafi Khezri, Hsiang‐Yin Hsueh, Somayeh Mohammadipanah, Javad Khalili Fard, Morteza Ghasemnejad‐Berenji · 2024 · Cell Proliferation
14. The PI3K/AKT/mTOR signaling pathway in breast cancer: Review of clinical trials and latest advances
    Ayda Baghery Saghchy Khorasani, Nasim Hafezi, Mohammad‐Javad Sanaei, Farideh Jafari‐Raddani, Atieh Pourbagheri‐Sigaroodi, Davood Bashash · 2024 · Cell Biochemistry and Function
15. Activation of EGFR-PI3K-AKT signaling is required for Mycoplasma hyorhinis-promoted gastric cancer cell migration
    Hongying Duan, Like Qu, Chengchao Shou · 2014 · Cancer Cell International
16. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM‐1
    Daniel G. Corum, Philip N. Tsichlis, Robin C. Muise‐Helmericks · 2013 · The FASEB Journal
17. Short-Chain Fatty Acid Propionate Alleviates Akt2 Knockout-Induced Myocardial Contractile Dysfunction
    Linlin Li, Yinan Hua, Jun Tao Ren · 2011 · Experimental Diabetes Research · Retracted
18. Melatonin Abrogates the Anti-Developmental Effect of the AKT Inhibitor SH6 in Bovine Oocytes and Embryos
    Marwa El-Sheikh, Ayman Mesalam, Ahmed Atef Mesalam, Muhammad Idrees, Kyeong‐Lim Lee, Il‐Keun Kong · 2019 · International Journal of Molecular Sciences
19. Isoform-specific Regulation of Akt Signaling by the Endosomal Protein WDFY2
    Helena A. Walz, Xiarong Shi, My Chouinard, Catherine A. Bue, Deanna M. Navaroli, Akira Hayakawa, Qiong L. Zhou, Jonathan Nadler, Deborah M. Leonard, Silvia Corvera · 2010 · Journal of Biological Chemistry
20. Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with nilotinib against BCR-ABL-positive leukemia cells involves the ABL kinase domain mutation
    Seiichi Okabe, Tetsuzo Tauchi, Yuko Tanaka, Toshihiko Kitahara, Shinya H Kimura, Taira Maekawa, Kazuma Ohyashiki · 2013 · Cancer Biology & Therapy
21. Impairment of insulin-stimulated Akt/GLUT4 signaling is associated with cardiac contractile dysfunction and aggravates I/R injury in STZ-diabetic Rats
    Jiung‐Pang Huang, Shiang‐Suo Huang, Jen-Ying Deng, Li‐Man Hung · 2009 · Journal of Biomedical Science
22. Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells
    Alfredo Toschi, Evan Lee, Sebastián A. Thompson, Noga Gadir, Paige Yellen, Charles Michael Drain, Michael Ohh, David A. Foster · 2010 · Cancer Letters
23. PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells
    Wallace Martins de Araújo, Bruno Kaufmann Robbs, Lilian G. Bastos, Waldemir Fernandes de Souza, Flávia Castello Branco Vidal, João P. B. Viola, José Andrés Morgado‐Díaz · 2015 · Journal of Cellular Biochemistry
24. Lipid-dependent Akt-ivity: where, when, and how
    Katharina M. Siess, Thomas A. Leonard · 2019 · Biochemical Society Transactions
25. Emerging role of Akt substrate protein AS160 in the regulation of AQP2 translocation
    Hyo-Young Kim, Hyo-Jung Choi, Jung-Suk Lim, Eui-Jung Park, Hyun Jun Jung, Yu-Jung Lee, Sang-Yeob Kim, Tae‐Hwan Kwon · 2011 · American Journal of Physiology-Renal Physiology
26. Akt2 Regulates Metastatic Potential in Neuroblastoma
    Jingbo Qiao, Sora Lee, Pritha Paul, Lan Qiao, Chase J. Taylor, Cameron E. Schlegel, Nadja C. Colon, Dai H. Chung · 2013 · PLoS ONE
27. In silicodrug design and molecular docking studies targeting Akt1 (RAC-alpha serine/threonine-protein kinase) and Akt2 (RAC-beta serine/threonine-protein kinase) proteins and investigation of CYP (cytochrome P450) inhibitors against MAOB (monoamine oxidase B) for OSCC (oral squamous cell carcinoma) treatment
    Mohammad Kawsar Sharif Siam, Anusree Sarker, Mohammad Manzur Sharif Sayeem · 2020 · Journal of Biomolecular Structure and Dynamics
28. Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis
    Arnaud Parcellier, Lionel A. J. Tintignac, Elena Zhuravleva, Peter D. Cron, Susanne Schenk, Lana Bozulic, Brian A. Hemmings · 2009 · Cellular Signalling
29. Sirt1 Inhibits Akt2-Mediated Porcine Adipogenesis Potentially by Direct Protein-Protein Interaction
    Weijun Pang, Yu Wang, Ning Wei, Ruxiang Xu, Yan Xiong, Ping Wang, Qingwu W. Shen, Gongshe Yang · 2013 · PLoS ONE
30. Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1
    He Wang, Mengjia Liu, Zhuoyang Ye, Cuihua Zhou, Huiru Bi, Long Wang, Chen Zhang, Hui Qun Fu, Ying Shen, Jianjun Yang et al. · 2021 · Journal of Neuroscience
31. A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB
    Mikiro Nawa, Kohsuke Kanekura, Yuichi Hashimoto, Sadakazu Aiso, Masaaki Matsuoka · 2007 · Cellular Signalling
32. Recent progress in the discovery of Akt inhibitors as anticancer agents
    Qun Li · 2007 · Expert Opinion on Therapeutic Patents
33. Asymmetric Dimethylarginine Induces Endothelial Nitric-oxide Synthase Mitochondrial Redistribution through the Nitration-mediated Activation of Akt1*
    Rafikov, Ruslan, Rafikova, Olga, Aggarwal, Saurabh, Gross, Christine, Sun, Xutong, Desai, Julin, Fulton, David, Black, Stephen M. · 2013 · Journal of Biological Chemistry
34. FANCI is a negative regulator of Akt activation
    Xiaoshan Zhang, Xiaoyan Lu, Shamima Akhter, Maria-Magdalena Georgescu, Randy J. Legerski · 2016 · Cell Cycle
35. Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia
    Shilpa Kuttikrishnan, Kodappully Sivaraman Siveen, Kirti Sathyananda Prabhu, Abdul Quaiyoom Khan, Sabah Akhtar, Jericha Miles Pamiloza Mateo, Maysaloun Merhi, Ruba Yasin Taha, Halima El Omri, Fatima Mraiche et al. · 2018 · Leukemia & lymphoma/Leukemia and lymphoma
36. Effects of PI3K catalytic subunit and Akt isoform deficiency on mTOR and p70S6K activation in myoblasts
    Ronald W. Matheny, Martin Louis Adamo · 2009 · Biochemical and Biophysical Research Communications
37. Phosphoinositide 3-Kinases
    David A. Fruman · 2010 · Elsevier eBooks
38. Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle
    Revati Wani, N. Sharmila Bharathi, Jeffrey M. Field, Allen W. Tsang, Cristina M. Furdui · 2011 · Cell Cycle
39. High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway
    Chen Ouyang, Zhiyong Cao, He Li, Zhouheng Ye, Rongjia Zhang, Ning Zhang, Junlong Huang, Ting Zhang, Liping Wang, Ling Han et al. · 2017 · Scientific Reports
40. The Akt–mTOR network at the interface of hematopoietic stem cell homeostasis
    Feng Wu, Zhe Chen, Jingbo Liu, Yu Hou · 2021 · Experimental Hematology
41. Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis
    Nan Hu, Maolong Dong, Jun Tao Ren · 2014 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
42. PKBβ/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors
    Sara Palumbo, Clare Paterson, Feng Yang, Veronica L. Hood, Amanda J. Law · 2020 · Molecular Psychiatry
43. Development of a new model system to dissect isoform specific Akt signalling in adipocytes
    Esi Kajno, Timothy E. McGraw, Eva Gonzalez · 2015 · Biochemical Journal
44. Translating traditional herbal formulas into modern drugs: a network-based analysis of Xiaoyao decoction
    Daiyan Zhang, Yun Zhang, Yan Gao, Xingyun Chai, Rongbiao Pi, Ging Chan, Hu Yuanjia · 2020 · Chinese Medicine
45. Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening
    Raju Subramanian, Matthew R. Lee, John G. Allen, Matthew P. Bourbeau, Christopher H. Fotsch, Fang‐Tsao Hong, Seifu Tadesse, Guomin Yao, Chester Yuan, Sekhar Surapaneni et al. · 2010 · Chemical Research in Toxicology
46. A Purified Capsular Polysaccharide Markedly Inhibits Inflammatory Response during Endotoxic Shock
    Miranda Piccioni, Claudia Monari, Samyr Kenno, Eva Pericolini, Elena Gabrielli, Donatella Pietrella, Stefano Perito, Francesco Bistoni, T R Kozel, Anna Vecchiarelli · 2012 · Infection and Immunity
47. Deletion of PKBα/Akt1 Affects Thymic Development
    Elisabeth Fayard, Jason W. Gill, Magdalena Paolino, Debby Hynx, Georg A. Holländer, Brian A. Hemmings · 2007 · PLoS ONE
48. Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules
    Richard M. Gunn, Helen Claire Hailes · 2008 · Journal of Chemical Biology
49. RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling
    Prudence H. Tso, Lisa Ying Yung, Yingchun Wang, Yung Hou Wong · 2011 · Cancer Letters
50. JNK3 Maintains Expression of the Insulin Receptor Substrate 2 (IRS2) in Insulin-Secreting Cells: Functional Consequences for Insulin Signaling
    Saida Abdelli, Christophe Bonny · 2012 · PLoS ONE
51. PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice
    No-Joon Song, Seo‐Hyuk Chang, Suji Kim, Vanja Panic, Byung-Hyun Jang, Ui Jeong Yun, Jin Hee Choi, Zhen Li, Ki-Moon Park, Jung-Hoon Yoon et al. · 2018 · Cell Death and Disease
52. Potential of Akt mediated DNA repair in radioresistance of solid tumors overexpressing erbB-PI3K-Akt pathway
    Mahmoud Toulany, H. Peter Rodemann · 2013 · Translational Cancer Research
53. In search of AKT kinase inhibitors as anticancer agents: structure-based design, docking, and molecular dynamics studies of 2,4,6-trisubstituted pyridines
    Pedro Josué Trejo–Soto, Alicia Hernández‐Campos, Antonio Romo‐Mancillas, José L. Medina‐Franco, Rafael Castillo · 2017 · Journal of Biomolecular Structure and Dynamics
54. Tumor Necrosis Factor (TNF)-α-induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-Iα Causes Insulin Resistance in 3T3-L1 Adipocytes
    Yasutoshi Ando, Yusuke Shinozawa, Yumi Iijima, Bu‐Chin Yu, Meri Sone, Yuko Ooi, Yusuke Watanaka, Kazuhiro Chida, Fumihiko Hakuno, Shin‐Ichiro Takahashi · 2015 · Journal of Biological Chemistry
55. Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis
    Jia-Xing Zhao, Yawei Yuan, Chengfu Cai, Dong‐Yan Shen, Mao-Li Chen, Feng Ye, Yanjun Mi, Qicong Luo, Wangyu Cai, Wei Zhang et al. · 2017 · Oncotarget
56. AKT‐dependent phosphorylation of the adenosine deaminases ADAR‐1 and ‐2 inhibits deaminase activity
    Alberto Bavelloni, Enrico Focaccia, Manuela Piazzi, Mirco Raffini, Valeriana Cesarini, Sara Tomaselli, Arianna Orsini, Stefano Ratti, Irene Faenza, Lucio Cocco et al. · 2019 · The FASEB Journal
57. TSC22D4 interacts with Akt1 to regulate glucose metabolism
    Sevgican Demir, Gretchen Wolff, Annika Wieder, Adriano Maida, Lea Bühler, Maik Brune, Oksana Hautzinger, Annette Feuchtinger, Tanja Poth, Julia Szendroedi et al. · 2022 · Science Advances
58. Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart
    Giannoula Lakka Klement, David A. Goukassian, Lynn Hlatky, Joseph Patrick Carrozza, James P. Morgan, Xinhua Yan · 2012 · Frontiers in Pharmacology
59. Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo
    David F. Restuccia, Debby Hynx, Brian A. Hemmings · 2012 · Disease Models & Mechanisms
60. Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy
    Jun Tao Ren, Zhaohui Pei, Xiyao Chen, Melissa J Berg, Khalid Matrougui, Qing-hua Zhang, Yingmei Zhang · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
61. MicroRNA dysregulation during chemical carcinogenesis
    Igor P. Pogribny · 2009 · Epigenomics
62. The Glycophorin A Transmembrane Sequence within Integrin αvβ3 Creates a Non-Signaling Integrin with Low Basal Affinity That Is Strongly Adhesive under Force
    Martina A. Müller, Jan Opfer, Leonora Brunie, Lilli A. Volkhardt, Eva‐Kathrin Sinner, David Charles Boettiger, Alexander Bochen, Horst Kessler, Kay‐Eberhard Gottschalk, Ute Reuning · 2013 · Journal of Molecular Biology
63. An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction
    Dougall M. Norris, Pengyi Yang, James Robert Krycer, Daniel J. Fazakerley, David Ernest James, James G. Burchfield · 2017 · Journal of Cell Science
64. 2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics
    Qingping Zeng, Matthew P. Bourbeau, G. Erich Wohlhieter, Guomin Yao, Holger Monenschein, James T. Rider, Matthew R. Lee, Shiwen Zhang, Julie A. Lofgren, Daniel J. Freeman et al. · 2010 · Bioorganic & Medicinal Chemistry Letters
65. Stoichiometric Quantification of Akt Phosphorylation Using LC-MS/MS
    Abdelmadjid Atrih, Dan Turnock, Grant C. Sellar, Alastair Thompson, Giora Feuerstein, Michael A. J. Ferguson, Jeffrey T.-J. Huang · 2009 · Journal of Proteome Research
66. Regulation of Adipocyte Differentiation by Distinct Subcellular Pools of Protein Kinase B (PKB/Akt)
    Tamara Maiuri, Jason Ho, Vuk Stambolic · 2010 · Journal of Biological Chemistry
67. Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3β signaling pathway
    Lei Peng, Dexiao Zhu, Xiaowen Feng, Haiman Dong, Qingwei Yue, Jing Zhang, Qing Gao, Jing Hao, Xingzhen Zhang, Zengxun Liu et al. · 2013 · Schizophrenia Research
68. Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain
    Long Wang, Shanshan Cheng, Zhenyu Yin, Congyu Xu, Shuangshuang Lu, Jinxing Hou, Tingting Yu, Xiaolei Zhu, Xiaoyan Zou, Ying Peng et al. · 2015 · Molecular Neurodegeneration
69. Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats
    Qiuxia Pan, Jia‐Jia Wu, Yueyun Liu, Xiaojuan Li, Jiaxu Chen · 2019 · Molecules
70. New players in high fat diet-induced obesity: LETM1 and CTMP
    Jisoo Park, Yuwen Li, Seon‐Hwan Kim, Keum-Jin Yang, Gyeyeong Kong, Robin Shrestha, Quangdon Tran, Kyeong Ah Park, Juhee Jeon, Gang Min Hur et al. · 2013 · Metabolism
71. Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells
    Avigail Dreazan Wittenberg, S. Azar, Agnes Klochendler, M. Stolovich-Rain, Shlomit Avraham, L. Birnbaum, Adi Binder Gallimidi, M. Katz, Y. Dor, O. Meyuhas · 2016 · PLoS ONE
72. Heat shock protein 90/Akt pathway participates in the cardioprotective effect of exogenous hydrogen sulfide against high glucose-induced injury to H9c2 cells
    Ke Xiao, Jingfu Chen, Longyun Peng, Wei Zhang, Yiying Yang, Xinxue Liao, Liqiu Mo, Ruixian Guo, Jianqiang Feng, Chengheng Hu et al. · 2017 · International Journal of Molecular Medicine
73. Betaine alleviates high glucose‑induced mesangial cell proliferation by inhibiting cell proliferation and extracellular matrix deposition via the AKT/ERK1/2/p38 MAPK pathway
    Xianhui Li, Li Wang, Huining Ma · 2019 · Molecular Medicine Reports
74. AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus
    Xin Zheng, Jun Xiao, Qi Jiang, Lingming Zheng, Chang Liu, Chen Dong, Yuxiao Zheng, Peili Ni, Chi Zhang, Fang Zhang et al. · 2022 · The EMBO Journal
75. Nuclear Akt2 Opposes Limbal Keratinocyte Stem Cell Self-Renewal by Repressing a FOXO-mTORC1 Signaling Pathway
    Stefania Saoncella, Beatrice Tassone, Erika Deklic, Fabio Avolio, Cristina Jon, Giusy Tornillo, Elisa De Luca, Enzo Di Iorio, Roberto Piva, Sara Cabodi et al. · 2013 · Stem Cells
76. Phosphorylation of the Twist1-Family Basic Helix-Loop-Helix Transcription Factors Is Involved in Pathological Cardiac Remodeling
    Shuangshuang Lu, Junwei Nie, Qing Luan, Qiuting Feng, Qi Xiao, Zai Chang, Congjia Shan, Daniel Heß, Brian A. Hemmings, Zhongzhou Yang · 2011 · PLoS ONE
77. Protein kinase B Akt regulation in diabetic kidney disease
    Derek P Brazil · 2010 · Frontiers in Bioscience-Scholar
78. Circular RNAs with protein-coding ability in oncogenesis
    Jiahui Cheng, Guangyue Li, Wenmeng Wang, Daniel B. Stovall, Guangchao Sui, Dangdang Li · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
79. Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion
    Shouye Wang, Marc D. Basson · 2007 · Experimental Cell Research
80. Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts
    Ronald W. Matheny, Martin Louis Adamo · 2009 · Biochemical and Biophysical Research Communications
81. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors
    Tatsuya Okuzumi, Gregory S. Ducker, Chao Zhang, Brian Aizenstein, Randy Hoffman, Kevan M. Shokat · 2010 · Molecular BioSystems
82. Pre-treatment with a Xingnaojing preparation ameliorates sevoflurane-induced neuroapoptosis in the infant rat striatum
    Zhoujing Yang, Yingwei Wang, Changlin Li, Liqing Ma, Xuan Zhao · 2014 · Molecular Medicine Reports
83. miR-718 is involved in malignancy of papillary thyroid cancer through repression of PDPK1
    Xiuyan Wang, Ming Qi · 2018 · Pathology - Research and Practice
84. Molecular Regulation of Lymphangiogenesis in Development and Tumor Microenvironment
    Taotao Li, Jianfeng Yang, Quansheng Zhou, Yulong He · 2012 · Cancer Microenvironment
85. Wuzi-Yanzong prescription alleviates spermatogenesis disorder induced by heat stress dependent on Akt, NF-κB signaling pathway
    Suqin Hu, Dian-Long Liu, Chunrui Li, Yahui Xu, Ke Hu, Lidan Cui, Jian Guo · 2021 · Scientific Reports
86. Coordination of RNA Processing Regulation by Signal Transduction Pathways
    Veronica Ruta, Vittoria Pagliarini, Claudio Sette · 2021 · Biomolecules
87. Crosstalk between PTEN/Akt2 and TGFβ signaling involving EGF receptor down‐regulation during the tumor promotion process from the early stage in a rat two‐stage hepatocarcinogenesis model
    Eriko Taniai, Masaomi Kawai, Yasuaki Dewa, Jihei Nishimura, Tomoaki Harada, Yukie Saegusa, Sayaka Matsumoto, Miwa Takahashi, Kunitoshi Mitsumori, Makoto Shibutani · 2009 · Cancer Science
88. An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis
    Kimita Suyama, Jiahong Yao, Huizhi Liang, Outhiriaradjou Benard, Olivier D. Loudig, Dulguun Amgalan, Wendy M. McKimpson, Greg R. Phillips, Jeffrey E. Segall, Yihong Wang et al. · 2017 · Cancer Research
89. Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein
    Longzhen Piao, Yuwen Li, Keum Jin Yang, Kyeong Ah Park, Hee Sun Byun, Minho Won, Jang Hee Hong, Jeong Lan Kim, Gi Ryang Kweon, Gang Min Hur et al. · 2009 · BMC Cell Biology
90. Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes
    Silvia C. Sookoian, Tomas Fernández Gianotti, Mariano Luis Schuman, Carlos Jose Pirola · 2009 · Genetics in Medicine
91. Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures
    Thomas J. Campion III, Imran S. Sheikh, Rupert D. Smit, Philip H. Iffland, Jie Chen, Ian P. Junker, Barbara Krynska, Peter B. Crino, George M. Smith · 2021 · Experimental Neurology
92. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance
    Stephan Wullschleger, Kei Sakamoto, Lana Johnstone, Suzanne Duce, Stewart Fleming, Dario R. Alessi · 2010 · Disease Models & Mechanisms
93. High-throughput Exploration of the Network Dependent on AKT1 in Mouse Ovarian Granulosa Cells
    Maëva Elzaïat, Laetitia Herman, Bérangère Legois, Thibaut Léger, Anne‐Laure Todeschini, Reiner A. Veitia · 2019 · Molecular & Cellular Proteomics
94. Zooming in and Out of Programmed Cell Death in Osteoarthritis: A Scientometric and Visualized Analysis
    Siyang Cao, Yihao Wei, Yaohang Yue, Ao Xiong, Hui Zeng · 2024 · Journal of Inflammation Research
95. Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses
    Deborah Balzano, Mohamad-Ali Fawal, José Vicente Velázquez, Clara María Santiveri, Joshua Yang, Joaquı́n Pastor, Ramón Campos‐Olivas, Nabil Djouder, Daniel Lietha · 2015 · Journal of Biological Chemistry
96. The Role of Heparin Cofactor Ⅱ in the Regulation of Insulin Sensitivity and Maintenance of Glucose Homeostasis in Humans and Mice
    Kiyoe Kurahashi, Seika Inoue, Sumiko Yoshida, Yasumasa Ikeda, Kana Morimoto, Ryoko Uemoto, Kazue Ishikawa, Takeshi Kondo, Tomoyuki Yuasa, Itsuro Endo et al. · 2017 · Journal of Atherosclerosis and Thrombosis
97. Akt/PKB isoforms expression in the human lumbar herniated disc: correlation with clinical and MRI findings
    Dritan Pasku, Giannoula Soufla, Pavlos Katonis, Alexandros Tsarouhas, Antonis F. Vakis, Demetrios A. Spandidos · 2011 · European Spine Journal
98. Targeting the phosphoinositide-3-kinase/protein kinase B pathway in airway innate immunity
    Indiwari Gopallawa, Robert J. Lee · 2020 · World Journal of Biological Chemistry
99. RNA-interference-mediated downregulation of Pin1 suppresses tumorigenicity of malignant melanoma A375 cells
    Jianqiu Jin, Y. ZHANG, Yunpeng Li, H. ZHANG, Huifang Li, Xiaoliang Yuan, Xiaoya Li, Wei Zhou, Baozhen Xu, C. ZHANG et al. · 2012 · Neoplasma
100. The Mechanisms of Insulin Action
     Morris F. White, Kyle D. Copps · 2015 · Elsevier eBooks