Physiological roles of PKB/Akt isoforms in development and disease

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,837 · see citing works

Pten is essential for embryonic development and tumour suppression

Cristofano, A. D., Pesce, B., Cordon‐Cardo, C., & Pandolfi, P. P. (1998) · Nature Genetics · doi:10.1038/1235 · Cited by 1,518 · see citing works

Perturbations of the AKT signaling pathway in human cancer

Altomare, D. A., & Testa, J. R. (2005) · Oncogene · doi:10.1038/sj.onc.1209085 · Cited by 1,326 · see citing works

Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation

Sano, H., Kane, S., Sano, E., Mı̂inea, C. P., Asara, J. M., Lane, W. S., Garner, C. W., & Lienhard, G. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300063200 · Cited by 964 · see citing works

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., & Birnbaum, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100462200 · Cited by 959 · see citing works

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

Podsypanina, K., Ellenson, L. H., Nemes, A., Gu, J., Tamura, M., Yamada, K. M., Cordon‐Cardo, C., Cattoretti, G., Fisher, P. E., & Parsons, R. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1563 · Cited by 947 · see citing works

Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 genePreprint

Chen, W. S., Xu, P.-Z., Gottlob, K., Chen, M.-L., Sokol, K. A., Shiyanova, T., Roninson, I. B., Weng, W., Suzuki, R., Tobe, K., et al. (2001) · Genes & Development · doi:10.1101/gad.913901 · Cited by 926 · see citing works

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2Preprint

Peng, X.-D., Xu, P.-Z., Chen, M.-L., Hahn-Windgassen, A., Skeen, J. E., Jacobs, J., Sundararajan, D., Chen, W. S., Crawford, S. E., Coleman, K. G., et al. (2003) · Genes & Development · doi:10.1101/gad.1089403 · Cited by 819 · see citing works

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

Nakae, J., Kitamura, T., Kitamura, Y., Biggs, W., Arden, K. C., & Accili, D. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00401-x · Cited by 727 · see citing works

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

Garofalo, R. S., Orena, S. J., Rafidi, K., Torchia, A. J., Stock, J. L., Hildebrandt, A. L., Coskran, T., Black, S. C., Brees, D. J., Wicks, J. R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16885 · Cited by 726 · see citing works

Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size

Easton, R., Cho, H., Roovers, K., Shineman, D. W., Mizrahi, M., Forman, M. S., Lee, V. M. ‐., Szabolcs, M. J., de Jong, R., Oltersdorf, T., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1869-1878.2005 · Cited by 551 · see citing works

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Lindsley, C. W., Zhao, Z., Leister, W., Robinson, R., Barnett, S. F., Defeo-Jones, D., Jones, R. E., Hartman, G. D., Huff, J. R., Huber, H. E., et al. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.11.011 · Cited by 504 · see citing works

Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.

Arboleda, M. J., Lyons, J. F., Kabbinavar, F. F., Bray, M. R., Snow, B. E., Ayala, R., Danino, M., Karlan, B. Y., & Slamon, D. J. (2003) · PubMed · Cited by 417 · see citing works

Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis

Tschopp, O., Yang, Z.-Z., Brodbeck, D., Dummler, B. A., Hemmings-Mieszczak, M., Watanabe, T., Michaelis, T., Frahm, J., & Hemmings, B. A. (2005) · Development · doi:10.1242/dev.01864 · Cited by 412 · see citing works

Akt Blocks Breast Cancer Cell Motility and Invasion through the Transcription Factor NFAT

Yoeli-Lerner, M., Yiu, G. K., Rabinovitz, I., Erhardt, P., Jauliac, S., & Toker, A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.033 · Cited by 403 · see citing works

Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth

Yang, Z.-Z., Tschopp, O., Hemmings-Mieszczak, M., Feng, J., Brodbeck, D., Perentes, E., & Hemmings, B. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302847200 · Cited by 384 · see citing works

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

Jiang, Z. Y., Zhou, Q. L., Coleman, K. A., Chouinard, M., Boese, Q., & Czech, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332633100 · Cited by 378 · see citing works

Isoform-specific Regulation of Insulin-dependent Glucose Uptake by Akt/Protein Kinase B

Bae, S. S., Cho, H., Mu, J., & Birnbaum, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306782200 · Cited by 312 · see citing works

Insulin-Stimulated Phosphorylation of the Akt Substrate AS160 Is Impaired in Skeletal Muscle of Type 2 Diabetic Subjects

Karlsson, H., Zierath, J. R., Kane, S., Krook, A., Lienhard, G. E., & Wallberg‐Henriksson, H. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1692 · Cited by 301 · see citing works

Physiological functions of protein kinase B/Akt

Yang, Z., Tschopp, O., Baudry, A., Dummler, B. A., Hynx, D., & Hemmings, B. A. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320350 · Cited by 286 · see citing works

Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies

Dummler, B. A., Tschopp, O., Hynx, D., Yang, Z., Dirnhofer, S., & Hemmings, B. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00722-06 · Cited by 282 · see citing works

Activation of Akt (Protein Kinase B) in Mammary Epithelium Provides a Critical Cell Survival Signal Required for Tumor Progression

Hutchinson, J. N., Jin, J., Cardiff, R. D., Woodgett, J. R., & Muller, W. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2203-2212.2001 · Cited by 281 · see citing works

Activation of Akt-1 (PKB-α) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion

Hutchinson, J. N., Jin, J., Cardiff, R. D., Woodgett, J. R., & Muller, W. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3465 · Cited by 251 · see citing works

The deficiency of Akt1 is sufficient to suppress tumor development in Pten +/− micePreprint

Chen, M.-L., Xu, P.-Z., Peng, X.-D., Chen, W. S., Guzman, G., Yang, X., Cristofano, A. D., Pandolfi, P. P., & Hay, N. (2006) · Genes & Development · doi:10.1101/gad.1395006 · Cited by 241 · see citing works

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

Luo, Y., Shoemaker, A. R., Liu, X., Woods, K. W., Thomas, S. A., de Jong, R., Han, E. K.-H., Li, T., Stoll, V. S., Powlas, J. A., et al. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0005 · Cited by 233 · see citing works

Bridging the GAP between insulin signaling and GLUT4 translocation

Watson, R. T., & Pessin, J. E. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.02.007 · Cited by 219 · see citing works

Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice

Yang, Z., Tschopp, O., Di‐Poï, N., Bruder, E., Baudry, A., Dummler, B. A., Wahli, W., & Hemmings, B. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10407-10418.2005 · Cited by 219 · see citing works

Protein Kinase B/AKT 1 Plays a Pivotal Role in Insulin-like Growth Factor-1 Receptor Signaling Induced 3T3-L1 Adipocyte Differentiation

Xu, J., & Liao, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402297200 · Cited by 211 · see citing works

Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding

Héron‐Milhavet, L., Franckhauser, C., Rana, V., Berthenet, C., Fisher, D., Hemmings, B. A., Fernandez, A., & Lamb, N. J. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00201-06 · Cited by 176 · see citing works

Mammary gland involution is delayed by activated Akt in transgenic mice

Schwertfeger, K. L., Richert, M. M., & Anderson, S. M. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.6.0663 · Cited by 169 · see citing works

The Akt/PKB Family of Protein Kinases: A Review of Small Molecule Inhibitors and Progress Towards Target Validation

Barnett, S., Bilodeau, M. T., & Lindsley, C. W. (2005) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026053507714 · Cited by 146 · see citing works

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles

Berwick, D. C., Dell, G. C., Welsh, G. I., Heesom, K. J., Hers, I., Fletcher, L. M., Cooke, F. T., & Tavaré, J. M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01517 · Cited by 143 · see citing works

Oncogenic transformation induced by membrane-targeted Akt2 and Akt3

Mende, I., Malstrom, S. E., Tsichlis, P. N., Vogt, P. K., & Aoki, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204486 · Cited by 102 · see citing works

Delayed mammary gland involution in MMTV-AKT1 transgenic mice

Ackler, S., Ahmad, S., Tobias, C. A., Johnson, M. D., & Glazer, R. I. (2002) · Oncogene · doi:10.1038/sj.onc.1205052 · Cited by 95 · see citing works

PKBα is required for adipose differentiation of mouse embryonic fibroblasts

Baudry, A., Yang, Z., & Hemmings, B. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.02792 · Cited by 94 · see citing works

Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

Yamada, E., Okada, S., Saito, T., Ohshima, K., Sato, M., Tsuchiya, T., Uehara, Y., Shimizu, H., & Mori, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200408182 · Cited by 93 · see citing works

Synip phosphorylation does not regulate insulin-stimulated GLUT4 translocation

Sano, H., Kane, S., Sano, E., & Lienhard, G. E. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.027 · Cited by 32 · see citing works

AKT/PKB signaling: navigating downstream

Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115 · see citing works

AKT/PKB Signaling: Navigating the Network

Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772 · see citing works

The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

Hoxhaj, G., & Manning, B. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0216-7 · Cited by 2,137 · see citing works

PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

Miricescu, D., Totan, A., Stănescu-Spînu, I.-I., Bădoiu, S. C., Ștefani, C., & Greabu, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010173 · Cited by 873 · see citing works

Biochemical and cellular properties of insulin receptor signalling

Haeusler, R. A., McGraw, T. E., & Accili, D. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.89 · Cited by 739 · see citing works

PI3K isoforms in cell signalling and vesicle trafficking

Bilanges, B., Posor, Y., & Vanhaesebroeck, B. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0129-z · Cited by 520 · see citing works

The Akt kinases: Isoform specificity in metabolism and cancer

Gonzalez, E., & McGraw, T. E. (2009) · Cell Cycle · doi:10.4161/cc.8.16.9335 · Cited by 474 · see citing works

Signalling by insulin and IGF receptors: supporting acts and new players

Siddle, K. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0022 · Cited by 456 · see citing works

Redox homeostasis: The Golden Mean of healthy living

Ursini, F., Maiorino, M., & Forman, H. J. (2016) · Redox Biology · doi:10.1016/j.redox.2016.01.010 · Cited by 418 · see citing works

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

Bozulic, L., Sürücü, B., Hynx, D., & Hemmings, B. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.024 · Cited by 386 · see citing works

Physiological regulation of Akt activity and stability.

Liao, Y., & Hung, M. (2010) · PubMed Central · Cited by 343 · see citing works

Genetic Alterations in the Phosphatidylinositol-3 Kinase/Akt Pathway in Thyroid Cancer

Xing, M. (2010) · Thyroid · doi:10.1089/thy.2010.1646 · Cited by 306 · see citing works

Targeting AKT for cancer therapy

Shariati, M., & Meric‐Bernstam, F. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1676726 · Cited by 295 · see citing works

Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

Freyberg, Z., Ferrando, S. J., & Javitch, J. A. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121873 · Cited by 288 · see citing works

The PKB/AKT Pathway in Cancer

Carnero, A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161210789941865 · Cited by 271 · see citing works

Insulin signalling in the heart

Bertrand, L., Horman, S., Beauloye, C., & Vanoverschelde, J. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn093 · Cited by 270 · see citing works

PKB/Akt-Dependent Regulation of Cell Motility

Xue, G., & Hemmings, B. A. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djs648 · Cited by 262 · see citing works

Regulation of Akt Signaling by Sirtuins

Pillai, V. B., Sundaresan, N. R., & Gupta, M. P. (2014) · Circulation Research · doi:10.1161/circresaha.113.300536 · Cited by 260 · see citing works

mTORC2 Activity Is Elevated in Gliomas and Promotes Growth and Cell Motility via Overexpression of Rictor

Masri, J., Bernath, A., Martin, J., Jo, O. D., Vartanian, R., Funk, A., & Gera, J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2223 · Cited by 253 · see citing works

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models

Carnero, A., & Paramio, J. M. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00252 · Cited by 234 · see citing works

Myocardial AKT: The Omnipresent Nexus

Sussman, M. A., Völkers, M., Fischer, K. M., Bailey, B., Cottage, C. T., Din, S., Gude, N. A., Avitabile, D., Alvarez, R., Sundararaman, B., et al. (2011) · Physiological Reviews · doi:10.1152/physrev.00024.2010 · Cited by 229 · see citing works

SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34

Mallo, G. V., Espina, M., Smith, A. C., Terebiznik, M. R., Alemán, A., Finlay, B. B., Rameh, L. E., Grinstein, S., & Brumell, J. H. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200804131 · Cited by 218 · see citing works

AKT/GSK3 signaling pathway and schizophrenia

Emamian, E. S. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00033 · Cited by 218 · see citing works

Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway

Choi, S. M., Tucker, D. F., Gross, D. N., Easton, R., DiPilato, L. M., Dean, A. S., Monks, B. R., & Birnbaum, M. J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00797-10 · Cited by 211 · see citing works

PIKKing on PKB: regulation of PKB activity by phosphorylation

Bozulic, L., & Hemmings, B. A. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.02.002 · Cited by 208 · see citing works

Fine tuning the immune response with PI3K

Fruman, D. A., & Bismuth, G. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00750.x · Cited by 201 · see citing works

Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling

Gonzalez, E., & McGraw, T. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901933106 · Cited by 192 · see citing works

PHLiPPing the switch on Akt and protein kinase C signaling

Brognard, J., & Newton, A. C. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.04.001 · Cited by 183 · see citing works

Signaling pathways in schizophrenia: emerging targets and therapeutic strategies

Karam, C. S., Ballon, J. S., Bivens, N. M., Freyberg, Z., Girgis, R. R., Lizardi-Ortiz, J. E., Markx, S., Lieberman, J. A., & Javitch, J. A. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.05.004 · Cited by 178 · see citing works

Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane

Katan, M., & Cockcroft, S. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200041 · Cited by 176 · see citing works

The versatile role of curcumin in cancer prevention and treatment: A focus on PI3K/AKT pathway

Hamzehzadeh, L., Atkin, S. L., Majeed, M. A., Butler, A. E., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26620 · Cited by 174 · see citing works

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

Heerding, D. A., Rhodes, N., Leber, J. D., Clark, T. J., Keenan, R. M., LaFrance, L. V., Li, M., Safonov, I. G., Takata, D. T., Venslavsky, J. W., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8004527 · Cited by 167 · see citing works

Regulation of Akt signaling activation by ubiquitination

Yang, W.-L., Wu, C.-Y., Wu, J., & Lin, H.-K. (2010) · Cell Cycle · doi:10.4161/cc.9.3.10508 · Cited by 164 · see citing works

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

Agarwal, E., Brattain, M. G., & Chowdhury, S. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.03.025 · Cited by 164 · see citing works

Phosphatidylinositol 3-kinase/Akt signaling as a key mediator of tumor cell responsiveness to radiation

Toulany, M., & Rodemann, H. P. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.07.003 · Cited by 166 · see citing works

Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets

Horman, S. R., Janas, M. M., Litterst, C. M., Wang, B., MacRae, I. J., Sever, M. J., Morrissey, D. V., Graves, P. R., Luo, B., Umesalma, S., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.03.015 · Cited by 162 · see citing works

PI3K/AKT/mTOR Signaling Regulates the Virus/Host Cell Crosstalk in HPV-Positive Cervical Cancer Cells

Bossler, F., Hoppe‐Seyler, K., & Hoppe‐Seyler, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092188 · Cited by 145 · see citing works

Protein kinase B: signalling roles and therapeutic targeting

Sale, E. M., & Sale, G. J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7274-9 · Cited by 142 · see citing works

Posttranslational regulation of Akt in human cancer

Chan, C., Jo, U., Kohrman, A. Q., Rezaeian, A. H., Chou, P.-C., Logothetis, C. J., & Lin, H. (2014) · Cell & Bioscience · doi:10.1186/2045-3701-4-59 · Cited by 139 · see citing works

Akt as a therapeutic target in cancer

Steelman, L. S., Stadelman, K. M., Chappell, W. H., Horn, S., Bäsecke, J., Cervello, M., Nicoletti, F., Libra, M., Stivala, F., Martelli, A. M., et al. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.9.1139 · Cited by 141 · see citing works

DNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum Resistance

Stronach, E. A., Chen, M. M., Maginn, E. N., Agarwal, R., Mills, G. B., Wasan, H. S., & Gabra, H. (2011) · Neoplasia · doi:10.1593/neo.111032 · Cited by 138 · see citing works

AKT Signaling in Physiology and Disease

Vasudevan, K. M., & Garraway, L. A. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_66 · Cited by 131 · see citing works

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

Bayascas, J. R., Wullschleger, S., Sakamoto, K., García‐Martínez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lang, F. J. W., Lipina, C., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02032-07 · Cited by 131 · see citing works

Akt: a key transducer in cancer

Tsai, P., Lai, Y., Manne, R., Tsai, Y.-S., Sarbassov, D. D., & Lin, H. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00860-9 · Cited by 131 · see citing works

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

Miao, L., Liu, Y., Huang, H., Liang, F., Ling, C., & Hu, Y. (2016) · eLife · doi:10.7554/elife.14908 · Cited by 122 · see citing works

Akt isoforms differentially regulate neutrophil functions

Chen, J., Tang, H., Hay, N., Xu, J., & Ye, R. D. (2010) · Blood · doi:10.1182/blood-2009-11-255323 · Cited by 122 · see citing works

PKB/Akt-dependent regulation of inflammation in cancer

Tang, F., Wang, Y., Hemmings, B. A., Rüegg, C., & Xue, G. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.018 · Cited by 120 · see citing works

G protein‐coupled receptor‐induced Akt activity in cellular proliferation and apoptosis

New, D. C., Wu, K. K. H., Kwok, A. W. S., & Wong, Y. H. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06116.x · Cited by 118 · see citing works

Use of Akt Inhibitor and a Drug-resistant Mutant Validates a Critical Role for Protein Kinase B/Akt in the Insulin-dependent Regulation of Glucose and System A Amino Acid Uptake

Green, C., Göransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, K., & Hundal, H. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802623200 · Cited by 113 · see citing works

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

Moore, S., Hunter, R. W., & Hers, I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202341 · Cited by 111 · see citing works

Redox regulation of the insulin signalling pathway

Lennicke, C., & Cochemé, H. M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101964 · Cited by 111 · see citing works

Potential role of Akt signaling in chronic kidney disease

Lan, A., & Du, J. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu196 · Cited by 109 · see citing works

PDK1: The Major Transducer of PI 3-Kinase Actions

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Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice

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Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development

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Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor

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The role of Akt1 in terminal stages of endochondral bone formation: Angiogenesis and ossification

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Helicobacter pyloriactivate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3β phosphorylation

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Intracellular Signaling by Akt: Bound to Be Specific

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Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function

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Akt Phosphorylates Connexin43 on Ser373, a “Mode-1” Binding Site for 14-3-3

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Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis

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Molecular substrates of schizophrenia: homeostatic signaling to connectivity

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Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation

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Integrated Akt/PKB Signaling in Immunomodulation and Its Potential Role in Cancer Immunotherapy

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JAM‐A regulates epithelial proliferation through Akt/β‐catenin signalling

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Biological chemistry and functionality of protein sulfenic acids and related thiol modifications

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Insulin Reveals Akt Signaling as a Novel Regulator of Norepinephrine Transporter Trafficking and Norepinephrine Homeostasis

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Arsenic Inhibits Myogenic Differentiation and Muscle Regeneration

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mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1

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Specific Roles of Akt iso Forms in Apoptosis and Axon Growth Regulation in Neurons

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Glibenclamide exerts an antitumor activity through reactive oxygen species–c-jun NH(2)-terminal kinase pathway in human gastric cancer cell line MGC-803

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Regulation of 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) by Src Involves Tyrosine Phosphorylation of PDK1 and Src Homology 2 Domain Binding

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FOSL1 Is Integral to Establishing the Maternal-Fetal Interface

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Akt3 is a privileged first responder in isozyme-specific electrophile response

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DNA-dependent Protein Kinase-mediated Phosphorylation of Protein Kinase B Requires a Specific Recognition Sequence in the C-terminal Hydrophobic Motif

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AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration

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Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape

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All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear

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Propofol-Induced Changes in Neurotrophic Signaling in the Developing Nervous System In Vivo

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AKT ISOFORMS-AS160-GLUT4: The defining axis of insulin resistance

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FKBP5 genetic variation

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Differential function of Akt1 and Akt2 in human adipocytes

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Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation

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Latent Inflammation and Insulin Resistance in Adipose Tissue

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Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells

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Chapter 13 Phosphorylation of IRS Proteins

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Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell Apoptosis

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PDK1 Regulates Vascular Remodeling and Promotes Epithelial-Mesenchymal Transition in Cardiac Development

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Modulation in Activation and Expression of Phosphatase and Tensin Homolog on Chromosome Ten, Akt1, and 3-Phosphoinositide-Dependent Kinase 1: Further Evidence Demonstrating Altered Phosphoinositide 3-Kinase Signaling in Postmortem Brain of Suicide Subjects

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Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions

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The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines

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Physiological roles of PKB isoforms in development, growth and glucose metabolism

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Protein kinase B : the beta version elucidating novel contributions of protein kinase B beta (PKBß/Akt2) to endocrine metabolism, PCOS and cancer

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Dissecting signalling by individual Akt/PKB isoforms, three steps at once

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Protein Kinase B (PKB/Akt), a Key Mediator of the PI3K Signaling Pathway

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The Akt kinases: Isoform specificity in metabolism and cancer

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