Bax-inhibiting peptides derived from Ku70 and cell-penetrating pentapeptides

Cellular uptake of the tat protein from human immunodeficiency virus

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Arginine-rich Peptides

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Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis

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Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

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Double identity for proteins of the Bcl-2 family

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Adv. Drug Delivery Rev.

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Cell-penetrating peptides: mechanism and kinetics of cargo delivery

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Conformation of the Bax C‐terminus regulates subcellular location and cell death

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Cell penetration by transportan

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Antennapedia homeobox peptide regulates neural morphogenesis.

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Acetylation of the C Terminus of Ku70 by CBP and PCAF Controls Bax-Mediated Apoptosis

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Transduction peptides: from technology to physiology

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Cellular uptake of an α-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically

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Membrane-permeable arginine-rich peptides and the translocation mechanisms

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A means to a DNA end: the many roles of Ku

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Cell Penetrating Peptides in Drug Delivery

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Cell-Penetrating Peptides: Mechanisms and Applications

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Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii.

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Flavokawain A, a Novel Chalcone from Kava Extract, Induces Apoptosis in Bladder Cancer Cells by Involvement of Bax Protein-Dependent and Mitochondria-Dependent Apoptotic Pathway and Suppresses Tumor Growth in Mice

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Cellular translocation of proteins by transportan

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Handbook of Cell-Penetrating Peptides

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Cell penetration by transportan

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Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors

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DNA repair: How Ku makes ends meet

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The kinetics and tissue distribution of protein transduction in mice

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Influence of protein transduction domains on intracellular delivery of macromolecules

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Membrane permeability commonly shared among arginine‐rich peptides

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Bax-inhibiting peptide derived from mouse and rat Ku70

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GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway

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Interaction of a Cyclin E Fragment with Ku70 Regulates Bax-Mediated Apoptosis

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Yeast as a tool for apoptosis research

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Hypoxia-induced retinal ganglion cell death and the neuroprotective effects of beta-adrenergic antagonists

Chen, Y., Yamada, H., Mao, W., Matsuyama, S., Aihara, M., & Araie, M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.027 · Cited by 56 · see citing works

The role of Bax-inhibiting peptide in retinal ganglion cell apoptosis after optic nerve transection

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Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it

Rashmi, R. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh213 · Cited by 45 · see citing works

Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis

Gama, V., Yoshida, T., Gómez, J. A., Basile, D. P., Mayo, L. D., Haas, A. L., & Matsuyama, S. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.11.016 · Cited by 34 · see citing works

Prolonged Survival of Mice with Acute Liver Failure with Transplantation of Monkey Hepatocytes Cultured with an Antiapoptotic Pentapeptide V5

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Assays for Studying Bax-Induced Lethality in the Yeast Saccharomyces cereνisiae

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Cell-Permeable Penta-Peptides Derived from Bax-Inhibiting Peptide

Gómez, J. A., Gama, V., & Matsuyama, S. (2006) · Pharmacology & toxicology · doi:10.1201/9781420006087.ch27 · Cited by 5 · see citing works

Cell-penetrating peptides: classes, origin, and current landscape

Milletti, F. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.03.002 · Cited by 811 · see citing works

Cell penetration: scope and limitations by the application of cell-penetrating peptides

Reißmann, S. (2014) · Journal of Peptide Science · doi:10.1002/psc.2672 · Cited by 267 · see citing works

Involvement of All-trans-retinal in Acute Light-induced Retinopathy of Mice

Maeda, A., Maeda, T., Golczak, M., Chou, S., Desai, A., Hoppel, C. L., Matsuyama, S., & Palczewski, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900322200 · Cited by 248 · see citing works

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

Grunnet, L. G., Aikin, R. A., Tonnesen, M., Paraskevas, S., Blaabjerg, L., Størling, J., Rosenberg, L. C., Billestrup, N., Maysinger, D., & Mandrup-Poulsen, T. R. (2009) · Diabetes · doi:10.2337/db08-0178 · Cited by 210 · see citing works

Cell penetrating peptides: the potent multi-cargo intracellular carriers

Kardani, K., Milani, A., Shabani, S. H., & Bolhassani, A. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1676720 · Cited by 199 · see citing works

Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis

Dumitru, R., Gama, V., Fagan, B. M., Bower, J. J., Swahari, V., Pevny, L., & Deshmukh, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.002 · Cited by 157 · see citing works

Predicting cell-penetrating peptides

Hansen, M., Kilk, K., & Langel, Ü. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.09.003 · Cited by 157 · see citing works

Deletion of Ku70, Ku80, or Both Causes Early Aging without Substantially Increased Cancer

Li, H., Vogel, H. S., Holcomb, V. B., Gu, Y., & Hasty, P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00785-07 · Cited by 151 · see citing works

Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity

Kudo, W., Hp, L., Smith, M. A., Zhu, X., Matsuyama, S., & Lee, H.-G. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.43 · Cited by 104 · see citing works

Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation

Amsel, A. D., Rathaus, M., Kronman, N., & Cohen, H. Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706700105 · Cited by 104 · see citing works

HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension

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Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties

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Brain-targeted drug delivery - nanovesicles directed to specific brain cells by brain-targeting ligands

Moreira, R., Nóbrega, C., de Almeida, L. P., & Mendonça, L. S. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02511-7 · Cited by 93 · see citing works

Peptides as Pharmacological Carriers to the Brain: Promises, Shortcomings and Challenges

Parrasia, S., Szabó, I., Zoratti, M., & Biasutto, L. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00523 · Cited by 90 · see citing works

Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer

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Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation

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Recent Developments in Peptide-Based Nucleic Acid Delivery

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Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery

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Classes of Cell-Penetrating Peptides

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Neuroprotective Effect of Bax-Inhibiting Peptide on Neonatal Brain Injury

Wang, X., Han, W., Du, X., Zhu, C., Carlsson, Y., Mallard, C. E., Jacotot, E. D., & Hagberg, H. (2010) · Stroke · doi:10.1161/strokeaha.110.589051 · Cited by 76 · see citing works

Cell-Penetrating Penta-Peptides (CPP5s): Measurement of Cell Entry and Protein-Transduction Activity

Gómez, J. A., Chen, J., Ngo, J., Hájková, D., Yeh, I., Gama, V., Miyagi, M., & Matsuyama, S. (2010) · Pharmaceuticals · doi:10.3390/ph3123594 · Cited by 74 · see citing works

Biodistribution of TAT or QLPVM coupled to receptor targeted liposomes for delivery of anticancer therapeutics to brain in vitro and in vivo

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The secret life of Bcl-2: Apoptosis-independent inhibition of DNA repair by Bcl-2 family members

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All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis

Sawada, O., Perusek, L., Kohno, H., Howell, S. J., Maeda, A., Matsuyama, S., & Maeda, T. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.04.003 · Cited by 67 · see citing works

A MedChem toolbox for cereblon-directed PROTACs

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Cell penetrating peptide inhibitors of Nuclear Factor-kappa B

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1988–2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research

Gallo, M., Defaus, S., & Andreu, D. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.11.010 · Cited by 64 · see citing works

Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax

Jensen, K. M., WuWong, D. J., Wong, S., Matsuyama, M., & Matsuyama, S. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219833624 · Cited by 60 · see citing works

Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization

Gama, V, Gomez, J. A., Mayo, L. D., Jackson, M. W., Danielpour, D., Song, K., Haas, A. L., Laughlin, M. J., & Matsuyama, S. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.6 · Cited by 46 · see citing works

Transduction of peptides and proteins into live cells by cell penetrating peptides

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The Ku complex: recent advances and emerging roles outside of non-homologous end-joining

Abbasi, S., Parmar, G., Kelly, R. D., Balasuriya, N., & Schild‐Poulter, C. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03801-1 · Cited by 47 · see citing works

Relationships between Cargo, Cell Penetrating Peptides and Cell Type for Uptake of Non-Covalent Complexes into Live Cells

Keller, A., Mußbach, F., Breitling, R., Hemmerich, P. H., Schaefer, B., Stefan Lorkowski, A., & Reißmann, S. (2013) · Pharmaceuticals · doi:10.3390/ph6020184 · Cited by 45 · see citing works

A Gold Nanoparticle Pentapeptide: Gene Fusion To Induce Therapeutic Gene Expression in Mesenchymal Stem Cells

Muroski, M. E., Morgan, T. J., Levenson, C. W., & Strouse, G. F. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505190q · Cited by 45 · see citing works

Therapeutic Modulation of Apoptosis: Targeting the BCL-2 Family at the Interface of the Mitochondrial Membrane

Nemec, K. N., & Khaled, A. R. (2008) · Yonsei Medical Journal · doi:10.3349/ymj.2008.49.5.689 · Cited by 44 · see citing works

CRM1 Protein-mediated Regulation of Nuclear Clusterin (nCLU), an Ionizing Radiation-stimulated, Bax-dependent Pro-death Factor

Leskov, K., Araki, S., Lavik, J., Gómez, J. A., Gama, V., Gonos, E. S., Trougakos, I. P., Matsuyama, S., & Boothman, D. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252957 · Cited by 41 · see citing works

Application of Cell Penetrating Peptides as a Promising Drug Carrier to Combat Viral Infections

Khairkhah, N., Namvar, A., & Bolhassani, A. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00679-1 · Cited by 43 · see citing works

The many futures for cell-penetrating peptides: how soon is now?

Howl, J., Nicholl, I. D., & Jones, S. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350767 · Cited by 41 · see citing works

Exploring the Chemical Features and Biomedical Relevance of Cell-Penetrating Peptides

Moreno‐Vargas, L. M., & Prada‐Gracia, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010059 · Cited by 39 · see citing works

Neuronal apoptosis in cerebral ischemia/reperfusion area following electrical stimulation of fastigial nucleus

Liu, J., Li, J., Yang, Y., Wang, X., Zhang, Z., & Zhang, L. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.131577 · Cited by 37 · see citing works

The World of Cell Penetrating: the Future of Medical Applications

Falanga, A., Lombardi, L., Galdiero, E., Genio, V. D., & Galdiero, S. (2020) · Future Medicinal Chemistry · doi:10.4155/fmc-2020-0140 · Cited by 37 · see citing works

Enhancing cellular uptake of GFP via unfolded supercharged protein tags

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The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond

Sui, H., Hao, M., Chang, W., & Imamichi, T. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.761983 · Cited by 35 · see citing works

A nanomedicine based combination therapy based on QLPVM peptide functionalized liposomal tamoxifen and doxorubicin against Luminal A breast cancer

Wang, X., Chen, X., Yang, X., Gao, W., He, B., Dai, W., Zhang, H., Wang, X., Wang, J., Zhang, X., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.12.360 · Cited by 33 · see citing works

Considerations on the Rational Design of Covalently Conjugated Cell-Penetrating Peptides (CPPs) for Intracellular Delivery of Proteins: A Guide to CPP Selection Using Glucarpidase as the Model Cargo Molecule

Behzadipour, Y., & Hemmati, S. (2019) · Molecules · doi:10.3390/molecules24234318 · Cited by 33 · see citing works

Post-treatment of Bax-inhibiting peptide reduces neuronal death and behavioral deficits following global cerebral ischemia

Han, B., Wang, Q., Cui, G., Shen, X., & Zhu, Z. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.12.008 · Cited by 33 · see citing works

Selective Uptake Into Drug Resistant Mammalian Cancer by Cell Penetrating Peptide-Mediated Delivery

Carnevale, K. J. F., Muroski, M. E., Vakil, P. N., Foley, M. E., Laufersky, G., Kenworthy, R., Zorio, D. A. R., Morgan, T. J., Levenson, C. W., & Strouse, G. F. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00429 · Cited by 30 · see citing works

The six amino acid antimicrobial peptide bLF cin6 penetrates cells and delivers siRNA

Fang, B., Guo, H., Zhang, M., Lu, J., & Ren, F. (2012) · FEBS Journal · doi:10.1111/febs.12093 · Cited by 30 · see citing works

Endogenous H2S resists mitochondria-mediated apoptosis in the adrenal glands via ATP5A1 S-sulfhydration in male mice

Wang, C., Du, J., Du, S., Liu, Y., Li, D., Zhu, X., & Ni, X. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.02.011 · Cited by 28 · see citing works

Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases

Ngo, J., Matsuyama, M., Kim, C., Poventud‐Fuentes, I., Bates, A., Siedlak, S. L., Lee, H.-G., Doughman, Y. Q., Watanabe, M., Liner, A. G., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.11 · Cited by 26 · see citing works

Synthesis and Fluorescent Properties of β-Pyridyl α-Amino Acids

Harkiss, A. H., Bell, J. D., Knuhtsen, A., Jamieson, A. G., & Sutherland, A. J. (2019) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.9b00036 · Cited by 26 · see citing works

Interaction of Caveolin-1 with Ku70 Inhibits Bax-Mediated Apoptosis

Zou, H., Volonté, D., & Galbiati, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039379 · Cited by 25 · see citing works

Deletion of Individual Ku Subunits in Mice Causes an NHEJ-Independent Phenotype Potentially by Altering Apurinic/Apyrimidinic Site Repair

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Ku70 is stabilized by increased cellular SUMO

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Ku80-deleted cells are defective at base excision repair

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Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells

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Bax-induced apoptosis shortens the life span of DNA repair defect Ku70-knockout mice by inducing emphysema

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Ku70 regulates Bax-mediated pathogenesis in laminin- 2-deficient human muscle cells and mouse models of congenital muscular dystrophy

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Hydrophobic and electrostatic interactions between cell penetrating peptides and plasmid DNA are important for stable non-covalent complexation and intracellular delivery

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Cell-Penetrating Penta-Peptides and Bax-Inhibiting Peptides: Protocol for Their Application

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Conditional Cell-Penetrating Peptide Exposure as Selective Nanoparticle Uptake Signal

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An evolutionary perspective on the role of mesencephalic astrocyte-derived neurotrophic factor (MANF): At the crossroads of poriferan innate immune and apoptotic pathways

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Bax-inhibiting peptide attenuates bleomycin-induced lung injury in mice

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Novel, tightly structurally related N-myristoyltransferase inhibitors display equally potent yet distinct inhibitory mechanisms

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Internalization of Nucleoside Phosphates into Live Cells by Complex Formation with Different CPPs and JBS-Nucleoducin

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Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death

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The C-terminus of interferon gamma receptor beta chain (IFNγR2) has antiapoptotic activity as a bax inhibitor

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Cell-Penetrating Peptides Targeting Mitochondria

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Identification of Ku70 Domain-Specific Interactors Using BioID2

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Protein and peptide nanostructures for drug and gene delivery

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Role of KU70, SIRT1, and SIRT6 Proteins in Diabetic Rat Testis Tissue

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Differential Regulation of Clusterin Isoforms by the Androgen Receptor

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Selective suppression of a subset of Bax‐dependent neuronal death by a cell permeable peptide inhibitor of Bax, BIP

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Apoptosis and inflammation regulation after injury to the developing brain

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Dual Functionalized Liposomes for Co-delivery of Anti-cancer Chemotherapeutics for Treatment of Brain Tumor

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Peptide Structure: Electrophysiological Analysis, Nuclear Magnetic Resonance Analysis, and Molecular Dynamics Simulation of Direct Penetration of Cell‐Penetrating Peptides through Bilayer Lipid Membranes

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Cellular Stress Responses to DNA Damage: An Intracellular Balance between Life, Senescence, and Death

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Improvement of Adeno-Associated Virus (AAV)-Based Technologies by Cell-Penetrating Penta-Peptides (CPP5s)

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Vecteurs peptidiques pour la délivrance d'oligonucléotides : conception, mécanisme d'internalisation cellulaire et applications à la régulation de l'épissage.

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Quantification of Cell Penetrating Peptide Uptake By Fluorescent Techniques

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Cell-Penetrating Peptides 797 Bax-inhibiting peptides derived from Ku70 and

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Cell-Penetrating Penta-Peptides and Bax-Inhibiting Peptides: Protocol for Their Application

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Cell Penetrating Activity of Bax Inhibiting Peptides (BIPs) and Its Utilization for Protein Transduction.

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Bax-inhibiting peptide derived from mouse and rat Ku70

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Cell-Permeable Penta- Peptides Derived from Bax-Inhibiting Peptide

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