Insulin action on the liver in vivo
Abstract
Insulin has a potent inhibitory effect on hepatic glucose production by direct action at hepatic receptors. The hormone also inhibits glucose production by suppressing both lipolysis in the fat cell and secretion of glucagon by the α-cell. Neural sensing of insulin levels appears to participate in control of hepatic glucose production in rodents, but a role for brain insulin sensing has not been documented in dogs or humans. The primary effect of insulin on the liver is its direct action.
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Under true physiological conditions, insulin action on the liver is mediated primarily via a direct effect.
“under true physiological conditions, insulin action on the liver is mediated primarily via a direct effect (32).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [32]
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- Authors
- Cherrington, A. D., Moore, M. C., Sindelar, D. K., & Edgerton, D. S.
- Affiliations
- Vanderbilt University (US)
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2007-10-25
- Volume
- 35
- Issue
- 5
- Pages
- 1171-1174
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2123285495
- Cited by
- 43
- References
- 16
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 1 · 2012: 1
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Society Transactions (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p60dk020593-31)
- National Institute of Diabetes and Digestive and Kidney Diseases (P60-DK020593, R37DK018243, R37 DK18243)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- insulin, liver, hepatic glucose production, insulin receptor, lipolysis, adipocytes, glucagon secretion, alpha cells, glucose homeostasis
- MeSH terms
- Animals, Humans, Insulin, Lipolysis, Liver, Nervous System Physiological Phenomena, Pancreas
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