The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Rho family GTPases
Abstract
Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton, although, in addition, they promote a wide range of other cellular activities. Changes in the actin cytoskeleton drive many dynamic aspects of cell behaviour, including morphogenesis, migration, phagocytosis and cytokinesis, and the dysregulation of Rho GTPases is associated with numerous human diseases and disorders.
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Cites
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002) · Nature · doi:10.1038/nature00859 · Cited by 835
Structure and control of the actin regulatory WAVE complex
Chen, Z., Borek, D., Padrick, S. B., Gomez, T. S., Metlagel, Z., Ismail, A. M., Umetani, J., Billadeau, D. D., Otwinowski, Z., & Rosen, M. K. (2010) · Nature · doi:10.1038/nature09623 · Cited by 500
Pai, S.-Y., Kim, C., & Williams, D. A. (2010) · Disease Markers · doi:10.1155/2010/380291 · Cited by 85
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Rab Proteins and the Compartmentalization of the Endosomal System
Wandinger-Ness, A., & Zerial, M. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022616 · Cited by 586
Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration
Stankiewicz, T. R., & Linseman, D. A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00314 · Cited by 391
Cook, D. R., Rossman, K. L., & Der, C. J. (2014) · Oncogene · doi:10.1038/onc.2013.362 · Cited by 378
Orgaz, J. L., Crosas-Molist, E., Sadok, A., Perdrix-Rosell, A., Maiques, O., Rodriguez-Hernandez, I., Monger, J., Mele, S., Georgouli, M., Bridgeman, V., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2019.12.003 · Cited by 151
Simvastatin suppresses breast cancer cell proliferation induced by senescent cells
Liu, S., Uppal, H., Demaria, M., Desprez, P.-Y., Campisi, J., & Kapahi, P. (2015) · Scientific Reports · doi:10.1038/srep17895 · Cited by 124
Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases
Guiler, W., Koehler, A., Boykin, C., & Lu, Q. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.661612 · Cited by 51
Namekata, K., Guo, X., Kimura, A., Arai, N., Harada, C., & Harada, T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007645 · Cited by 40
Amado-Azevedo, J., Valent, E. T., & Van Nieuw Amerongen, G. P. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1828-6 · Cited by 36
Systematic review of genome-wide association studies on susceptibility to endometriosis
Cardoso, J. V., Perini, J. A., Machado, D. E., Pinto, R., & Medeiros, R. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.10.017 · Cited by 36
RHO Family GTPases in the Biology of Lymphoma
Voena, C., & Chiarle, R. (2019) · Cells · doi:10.3390/cells8070646 · Cited by 35
Ly, N., & Cyert, M. S. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-06-0432 · Cited by 14
Metadata
- Authors
- Hall, A.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2012-11-21
- Volume
- 40
- Issue
- 6
- Pages
- 1378-1382
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2064843753
- Cited by
- 517
- References
- 3
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
