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Cited by 517

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Rho family GTPases

Hall, Alan·2012·Biochemical Society Transactions

Abstract

Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton, although, in addition, they promote a wide range of other cellular activities. Changes in the actin cytoskeleton drive many dynamic aspects of cell behaviour, including morphogenesis, migration, phagocytosis and cytokinesis, and the dysregulation of Rho GTPases is associated with numerous human diseases and disorders.

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Crossref · 10.1042/bst20120103

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Metadata

Authors
Hall, A.
Venue
Biochemical Society Transactions
Published
2012-11-21
Volume
40
Issue
6
Pages
1378-1382
ISSN
  • 0300-5127 (ISSN-L)
  • 1470-8752
OpenAlex
W2064843753
Cited by
517
References
3
FWCI
14.87
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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