The methodology of TSPO imaging with positron emission tomography

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Items 101–200 of 237

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2. Clinical evaluation of neuroinflammation in child-onset focal epilepsy: a translocator protein PET study
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3. Brain Metabolism and Microglia Activation in Mild Cognitive Impairment: A Combined [18F]FDG and [11C]-(R)-PK11195 PET Study
   Giacomo Tondo, Cecilia Boccalini, Silvia Paola Caminiti, Luca Presotto, Massimo Filippi, Giuseppe Magnani, Giovanni Battista Frisoni, Sandro Iannaccone, Daniela Perani · 2021 · Journal of Alzheimer s Disease
4. (Micro)Glia as Effectors of Cortical Volume Loss in Schizophrenia
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5. Test-retest analysis of a non-invasive method of quantifying [11C]-PBR28 binding in Alzheimer’s disease
   Akshay Nair, Mattia Veronese, Xiaohui Xu, Charles J. C. Curtis, Federico Turkheimer, Robert J. Howard, Suzanne Reeves · 2016 · EJNMMI Research
6. Exploring the heterogeneity of MS lesions using positron emission tomography: a reappraisal of their contribution to disability
   Bruno Stankoff, Émilie Poirion, Mattéo Tonietto, Benedetta Bodini · 2018 · Brain Pathology
7. Resolving the cellular specificity of TSPO imaging in a rat model of peripherally-induced neuroinflammation
   Vicente-Rodríguez, Marta, Singh, Nisha, Turkheimer, Federico, Peris-Yague, Alba, Randall, Karen, Veronese, Mattia, Simmons, Camilla, Karim Haji-Dheere, Abdul, Bordoloi, Jayanta, Sander, Kerstin et al. · 2021 · Brain, Behavior, and Immunity
8. An In Vivo 11C-(R)-PK11195 PET and In Vitro Pathology Study of Microglia Activation in Creutzfeldt-Jakob Disease
   Leonardo Iaccarino, Rosa Maria Moresco, Luca Presotto, Orso Bugiani, Sandro Iannaccone, Giorgio Giaccone, Fabrizio Tagliavini, Daniela Perani · 2017 · Molecular Neurobiology
9. A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies
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10. PET Imaging Unveils Neuroinflammatory Mechanisms in Psychiatric Disorders: From Microglial Activation to Therapeutic Innovation
    Yu-dan Liu, Yiheng Chang, Xueting Xie, Xinyao Wang, Hao-yan Ma, Meichen Liu, Huimin Zhang · 2025 · Molecular Neurobiology
11. Microglia and schizophrenia: where next?
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12. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
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13. What value can TSPO PET bring for epilepsy treatment?
    Viviane Bouilleret, Stefanie Dedeurwaerdere · 2021 · European Journal of Nuclear Medicine and Molecular Imaging
14. Passive and receptor mediated brain delivery of an anti-GFAP nanobody.
    Silvio R. Meier, D. Sehlin, S. Syvänen · 2022 · Nuclear Medicine and Biology
15. Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An in vivo PET Study With Neuropathological Comparison
    Paul Kenneth Wright, Mattia Veronese, Ndaba Mazibuko, Federico Turkheimer, Eugenii A. Rabiner, Clive G. Ballard, Steven Williams, Avinash Kumar Hari Narayanan, Bahiya Osrah, Ricky Williams et al. · 2020 · Frontiers in Neurology
16. The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity
    Michele Frison, Danilo Faccenda, Rosella Abeti, Manuel Rigon, Daniela Strobbe, Britannie S. England-Rendon, Diana Cash, Katy Barnes, Mona Sadeghian, Marija Sajic et al. · 2021 · Molecular Psychiatry
17. Imaging brain inflammation and blood brain barrier permeability in neurological and psychiatric diseases: a review
    Zanetta Kovbasyuk, Eden Tefera, Chenyang Li, Steven H. Baete, Claude Steriade · 2025 · Journal of Neuroinflammation
18. Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis
    L. De Picker, M. Morrens · 2020 · Frontiers in Psychiatry
19. PET Neuroimaging in Dementia Conditions
    Daniela Perani, Silvia Paola Caminiti, Giulia Carli, Giacomo Tondo · 2020 · Springer eBooks
20. The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site
    Camilo J. Rojas, Marigo J. Stathis, Jennifer Marie Coughlin, Martin G. Pomper, Barbara Stauch Slusher · 2017 · Journal of Neuroimmune Pharmacology
21. Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge—Preliminary findings
    Maria Yanez Lopez, Marie‐Christine Pardon, Kerstin Baiker, Malcolm J. W. Prior, Yuchun Ding, Alessandra Agostini, Li Bai, Dorothee P. Auer, Henryk Faas · 2019 · PLoS ONE
22. Evaluation of [ 18 F]FNM biodistribution and dosimetry based on whole-body PET imaging of rats
    Anne‐Sophie Salabert, Erick Mora‐Ramirez, Marie Beaurain, Mathieu Alonso, Charlotte Fontan, Hafid Belhadj‐Tahar, Marie-Laure Boizeau, Mathieu Tafani, Manuel Bardiès, Pierre Payoux · 2017 · Nuclear Medicine and Biology
23. Mapping of Translocator Protein (18 kDa) in Peripheral Sterile Inflammatory Disease and Cancer through PET Imaging
    Anupriya Adhikari, Priya Singh, Kamalesh Singh Mahar, Manish Adhikari, Bhawana Adhikari, Ming‐Rong Zhang, Anjani K. Tiwari · 2021 · Molecular Pharmaceutics
24. In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease
    R. Schollhammer, S. Lepreux, N. Barthe, D. Vimont, A. Rullier, I. Sibon, X. Bérard, Andrea Zhang, Yasuyuki Kimura, M. Fujita et al. · 2021 · EJNMMI Research
25. Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies
    Junchao Tong, Belinda Williams, P. Rusjan, R. Mizrahi, J. Lacapere, T. McCluskey, Y. Furukawa, M. Guttman, L. Ang, I. Boileau et al. · 2020 · Journal of Cerebral Blood Flow and Metabolism
26. Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease
    Vicente-Rodríguez, Marta, Mancuso, Renzo, Peris-Yague, Alba, Simmons, Camilla, NIMA Consortium, Wlazly, Dominika, Dickinson, Amber, Foster, Andy, Knight, Clare, Leckey, Claire et al. · 2023 · Journal of Neuroinflammation
27. Innate immune cells and myelin profile in multiple sclerosis: a multi-tracer PET/MR study
    Milena Sales Pitombeira, Michel J. B. Koole, Kenia Repiso Campanholo, Araceli Belisario Pinto de Souza, Fábio Duran, Davi Jorge Fontoura Solla, María Fernanda Mendes, Samira Luísa Apóstolos‐Pereira, Carolina de Medeiros Rimkus, Geraldo F. Busatto et al. · 2022 · European Journal of Nuclear Medicine and Molecular Imaging
28. Synthesis and Evaluation of Tricarbonyl 99mTc-Labeled 2-(4-Chloro)phenyl-imidazo[1,2-a]pyridine Analogs as Novel SPECT Imaging Radiotracer for TSPO-Rich Cancer
    Ji Young Choi, Rosa Maria Iacobazzi, Maria Grazia Perrone, Nicola Margiotta, Annalisa Cutrignelli, Jae Ho Jung, Do Joong Park, Byung Moon, Nunzio Denora, Sang Kyum Kim et al. · 2016 · International Journal of Molecular Sciences
29. Temporal changes in neuroinflammation and brain glucose metabolism in a rat model of viral vector-induced α-synucleinopathy
    Melissa Crabbé, Anke Van der Perren, Savannah Kounelis-Wuillaume, Thomas Lavreys, Guy M Bormans, Veerle Baekelandt, Cindy Casteels, Koen Van Laere · 2019 · Experimental Neurology
30. Dopamine and Neuroinflammation in Schizophrenia – Interpreting the Findings from Translocator Protein (18kDa) PET Imaging
    Sotiria Maria Iliopoulou, Stergios Tsartsalis, Stefan Kaiser, P. Millet, Benjamin B. Tournier · 2021 · Neuropsychiatric Disease and Treatment
31. Translocator Protein (18 kDa) Polymorphism (rs6971) in the Korean Population
    Hyon Lee, Young Noh, Woo‐Ram Kim, Ha‐Eun Seo, Hyeon-Mi Park · 2022 · Dementia and Neurocognitive Disorders
32. Quantitative assessment of translocator protein (TSPO) in the non-human primate brain and clinical translation of [18F]LW223 as a TSPO-targeted PET radioligand
    Zhiqiang Tan, Ahmed Haider, Shaojuan Zhang, Jiahui Chen, Junjie Wei, Kai Liao, Guocong Li, Huiyi Wei, Chenchen Dong, Wenqing Ran et al. · 2023 · Pharmacological Research
33. Physically informed deep neural networks for metabolite-corrected plasma input function estimation in dynamic PET imaging
    Matteo Ferrante, Marianna Inglese, Ludovica Brusaferri, Alexander C. Whitehead, Lucia Maccioni, Federico Turkheimer, Maria Antonietta Nettis, Valeria Mondelli, Oliver David Howes, Marco L. Loggia et al. · 2024 · Computer Methods and Programs in Biomedicine
34. In vivo quantification of glial activation in minipigs overexpressing human α‐synuclein
    Thea Pinholt Lillethorup, Andreas Nørgaard Glud, Natalie Landeck, Aage Kristian Olsen Alstrup, Steen Jakobsen, Kim Vang, Doris J. Doudet, David James Brooks, Deniz Kirik, Rainer Hinz et al. · 2018 · Synapse
35. Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge
    Oliver Cousins, Julia J. Schubert, Avinash Chandra, Mattia Veronese, Polena Valkimadi, Byron Creese, Zunera Khan, Ryan Arathimos, Adam Hampshire, Ivana Rosenzweig et al. · 2023 · Journal of Neuroinflammation
36. Glial cell crosstalk in Parkinson's disease: Mechanisms, implications, and therapeutic strategies
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37. In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration
    Jeanette M. Metzger, Colleen F. Moore, Carissa Boettcher, Kevin G. Brunner, Rachel A. Fleddermann, Helen N. Matsoff, Henry Resnikoff, Viktoriya Bondarenko, Timothy J. Kamp, Timothy A. Hacker et al. · 2018 · npj Parkinson s Disease
38. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
    Elena Rodriguez‐Vieitez, Amit Kumar, Mona‐Lisa Malarte, Konstantinos Ioannou, Filipa Monteiro Rocha, Konstantinos Chiotis · 2024 · Methods in molecular biology
39. Comparison of two different methods of image analysis for the assessment of microglial activation in patients with multiple sclerosis using (R)-[N-methyl-carbon-11]PK11195
    Yeona Kang, David J. Schlyer, Ulrike W. Kaunzner, Amy F. Kuceyeski, Paresh J. Kothari, Susan A. Gauthier · 2018 · PLoS ONE
40. Neuroinflammation in cognitive decline post-cardiac surgery (the FOCUS study): an observational study protocol
    Annemieke M. Peters van Ton, Harmke B. Duindam, Julia van Tuijl, Wilson W. L. Li, Hendrik-Jan Dieker, Niels Peter Riksen, Frederick J. A. Meijer, Roy P. C. Kessels, Nils Kohn, Johannes G. van der Hoeven et al. · 2021 · BMJ Open
41. Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration
    Jeanette M. Metzger, Helen N. Matsoff, Alexandra D. Zinnen, Rachel A. Fleddermann, Viktoriya Bondarenko, Heather A. Simmons, Andres F. Mejia, Colleen F. Moore, Marina Elena Emborg · 2020 · PLoS ONE
42. Neuroinflammation in Children With Infantile Spasms: A Prospective Study Before and After Treatment With Acthar Gel (Repository Corticotropin Injection)
    Harry T. Chugani, Ajay Kumar · 2020 · Journal of Child Neurology
43. Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain
    Daniel Martins, Alessio Giacomel, Steven Williams, Federico Turkheimer, Ottavia Dipasquale, Mattia Veronese, PET templates working group · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
44. Targeting the Translocator Protein (18 kDa) in Cardiac Diseases: State of the Art and Future Opportunities
    Emma Baglini, Valeria Poggetti, Chiara Cavallini, Debora Petroni, Francesca Forini, Giuseppina Nicolini, Elisabetta Barresi, Silvia Salerno, Barbara Costa, Patricia Iozzo et al. · 2023 · Journal of Medicinal Chemistry
45. The association of psychosocial risk factors for mental health with a brain marker altered by inflammation: A translocator protein (TSPO) PET imaging study
    Tarik Dahoun, Marilia Calcia, Mattia Veronese, Peter S. Bloomfield, Tiago Reis Marques, Federico Turkheimer, Oliver David Howes · 2019 · Brain Behavior and Immunity
46. Longitudinal mouse-PET imaging: a reliable method for estimating binding parameters without a reference region or blood sampling
    Catriona Wimberley, Duc Loc Nguyen, Charles Truillet, Marie‐Anne Peyronneau, Zuhal Gulhan, Mattéo Tonietto, Fawzi Boumezbeur, Raphaël Boisgard, Sylvie Chalon, Viviane Bouilleret et al. · 2020 · European Journal of Nuclear Medicine and Molecular Imaging
47. Glial activation positron emission tomography imaging in radiation treatment of breast cancer brain metastases
    S. Badiuk, J. Thiessen, S. Maleki Vareki, P. Foster, Jeff Z. Y. Chen, E. Wong · 2022 · Physics and Imaging in Radiation Oncology
48. Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies
    Daniela Perani, Leonardo Iaccarino, Andreas Hans Jacobs, IMBI Brain Imaging Working Group, Adriaan A. Lammertsma, Agneta K. Nordberg, Albert D. Windhorst, Alexander Gerhard, Alexandra Winkeler, Andreas Hans Jacobs et al. · 2019 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
49. Synthesis and biological evaluation of [18F]fluorovinpocetine, a potential PET radioligand for TSPO imaging.
    S. Nag, R. Krasikova, A. Airaksinen, R. Arakawa, M. Petukhovd, B. Gulyás · 2019 · Bioorganic & Medicinal Chemistry Letters
50. An in vivo 11C‐ PK PET study of microglia activation in Fatal Familial Insomnia
    Leonardo Iaccarino, Luca Presotto, Valentino Bettinardi, Luigi Gianolli, Ignazio Roiter, Sabina Capellari, Piero Parchi, Pietro Cortelli, Daniela Perani · 2017 · Annals of Clinical and Translational Neurology
51. Response to Narendran and Frankle: The Interpretation of PET Microglial Imaging in Schizophrenia
    Peter S. Bloomfield, Oliver David Howes, Federico Turkheimer, Sudhakar Selvaraj, Mattia Veronese · 2016 · American Journal of Psychiatry
52. Candidate Tracers for Imaging Colony-Stimulating Factor 1 Receptor in Neuroinflammation with Positron Emission Tomography: Issues and Progress
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53. Investigating the potential of minocycline in reducing brain inflammation in chronic low back pain: a randomized, placebo-controlled mechanistic clinical trial
    Mehrbod Mohammadian, Erin Janas Morrissey, Paulina C. Knight, Ludovica Brusaferri, Minhae Kim, Nikos Efthimiou, Jennifer P. Murphy, Zeynab Alshelh, Grace Grmek, Jack H. Schnieders et al. · 2025 · Pain
54. Microglial translocator protein and stressor-related disorder
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55. Efficient radiosynthesis and non-clinical safety tests of the TSPO radioprobe [18F]FEDAC: Prerequisites for clinical application
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56. From positron emission tomography to cell analysis of the 18-kDa Translocator Protein in mild traumatic brain injury
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57. Recent developments and challenges in positron emission tomography imaging of gliosis in chronic neuropathic pain
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58. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV
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59. The Immune System and Depression: From Epidemiological to Clinical Evidence
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60. Positron emission tomography to image cerebral neuroinflammation in ischaemic stroke: a pilot study
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61. PET Imaging of Neuroinflammation
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62. A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging
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63. A novel blood-free analytical framework for the quantification of neuroinflammatory load from TSPO PET imaging
    Lucia Maccioni, Ludovica Brusaferri, Leonardo Barzon, Julia J. Schubert, Maria Antonietta Nettis, Oliver Cousins, Ivana Rosenzweig, Yuya Mizuno, Marta Vicente‐Rodríguez, Nisha Singh et al. · 2025 · Journal of Cerebral Blood Flow & Metabolism
64. Radiosynthesis of [18F]AV1451 in pharmaceutical conditions and its biological characteristics
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65. [18F]FEDAC translocator protein positron emission tomography–computed tomography for early detection of mitochondrial dysfunction secondary to myocardial ischemia
    Rui Luo, Lei Wang, Fei Ye, Yan-Rong Wang, Wei Fang, Ming‐Rong Zhang, Feng Wang · 2021 · Annals of Nuclear Medicine
66. Unravelling neuroinflammation in abusive head trauma with radiotracer imaging
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67. Glial Cells in Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Frontiers
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68. Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types
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69. Assessment of simplified methods for quantification of [ 18 F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate
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70. Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs
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71. 11C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls: a cross-sectional study
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72. Perspectives in TSPO PET Imaging for Neurologic Diseases
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73. Reply
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74. Seizing the Neuroinflammatory Target: The Quest Continues
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75. Cigarette smoking is associated with reduced neuroinflammation and better cognitive control in people living with HIV
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76. Progress and Challenges in the Development of PET Ligands to Aid CNS Drug Discovery
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77. Parametric Mapping for TSPO PET Imaging with Spectral Analysis Impulsive Response Function
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81. Preclinical characterization of [18F]D2-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates
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82. Using the Mouse to Model Human Diseases: Cognitive Impairment in Systemic Lupus Erythematosus
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83. PET is necessary to make the next step forward in understanding MS pathophysiology – No
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84. Critical role of translocator protein (TSPO) in neuronal mitochondrial dysfunction and mental stress-exacerbated ischemic injury following stroke
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85. Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis
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86. A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([18F]GE-180) PET/MRI
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88. The 18 kDa Translocator Protein (TSPO): Cholesterol Trafficking and the Biology of a Prognostic and Therapeutic Mitochondrial Target
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89. [11C]PBR‐28 positron emission tomography in multiple sclerosis: Neuroinflammation or otherwise?
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90. Spinal cord metabolism in multiple sclerosis: a decade of missed opportunities and future directions
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91. Research progress in neuroimaging of sporadic early-onset Alzheimer’s disease
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92. Role of mitochondria in brain functions and related disorders
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93. Preliminary study on the dynamic positron emission tomography imaging with 11C‐ER176 to delineate macrophage activation in diabetic gastroparesis
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94. Potential of miRNA as Imaging Targets for PET
    Simon H. Zientek, Stephen Thompson, Franklin I. Aigbirhio, Selena Milicevic Sephton · 2024 · Helvetica Chimica Acta
95. Novel targets for positron emission tomography (PET) radiopharmaceutical tracers for visualization of neuroinflammation
    И. А. Щепеткин, Maria Shvedova, Yana Anfinogenova, Maxim M. Litvak, Dmitriy N. Atochin · 2017 · Journal of Physics Conference Series
96. Microglia and Psychiatric Disorders
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97. Validating the Utility of Supervised Clustering Algorithm for Precise [11C]DPA-713 PET Brain Image Quantification
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98. Finding the Fire: Mapping Brain Temperature Elevations as a Surrogate of Focal Neuroinflammation
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99. Multiparametric MRI assessment of acute neuroinflammation in a murine model of peripheral LPS stimulation
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100. Translocator Protein (TSPO)
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