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Cited by 31Cellular transport and secretionPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking

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Yoshioka, Kazuaki·2021·Biochemical Society Transactions
DOI 10.1042/bst20200835PMC PMC8106491
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Abstract

Phosphatidylinositol 3-kinases (PI3Ks) are critical regulators of many cellular processes including cell survival, proliferation, migration, cytoskeletal reorganization, and intracellular vesicular trafficking. They are a family of lipid kinases that phosphorylate membrane phosphoinositide lipids at the 3' position of their inositol rings, and in mammals they are divided into three classes. The role of the class III PI3K Vps34 is well-established, but recent evidence suggests the physiological significance of class II PI3K isoforms in vesicular trafficking. This review focuses on the recently discovered functions of the distinct PI3K-C2α and PI3K-C2β class II PI3K isoforms in clathrin-mediated endocytosis and consequent endosomal signaling, and discusses recently reported data on class II PI3K isoforms in different physiological contexts in comparison with class I and III isoforms.

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  • The PI3K/AKT/mTOR pathway is a major downstream signaling cascade of EGFR and represents an important bypass mechanism contributing to resistance to cetuximab and panitumumab.

    “The phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway is a major downstream signaling cascade of EGFR and represents an important bypass mechanism contributing to resistance to cetuximab and panitumumab [40,41,42,43,44].”

    From Overcoming Resistance to Anti-EGFR Therapies: Mechanisms of Cetuximab and Panitumumab Resistance and Emerging Combination Strategies (2026) · cites this paper as [42]

    The ‘Cellular functions of class II PI3K isoforms’ section discusses PI3K regulation of Akt and mTORC1, but does not identify the PI3K/AKT/mTOR pathway as a major downstream cascade of EGFR. Neither that section nor the passages retrieved for cetuximab, panitumumab and resistance address a bypass mechanism for those drugs. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

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Authors
Yoshioka, K.
Affiliations
Kanazawa University (JP)
Corresponding author
Yoshioka, Kazuaki
ORCID
Yoshioka, Kazuaki
Venue
Biochemical Society Transactions
Publisher
Portland Press Ltd.
Published
2021-03-05
Volume
49
Issue
2
Pages
893-901
ISSN
  • 0300-5127 (ISSN-L)
  • 1470-8752
DOI
10.1042/bst20200835
PMC
PMC8106491
OpenAlex
W3135559486
Cited by
31
References
2
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FWCI
0.57
Type
journal article
Language
en
Open access
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Locations
  • Biochemical Society Transactions (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
PI3K-C2α, vesicle trafficking, clathrin-mediated endocytosis, endosomal signaling, phosphoinositide 3-phosphate, Vps34, lipid kinase, membrane trafficking
MeSH terms
Animals, Biological Transport, Endocytosis, Humans, Isoenzymes, Endosomes, Signal Transduction, Cytoplasmic Vesicles, Intracellular Space, Class II Phosphatidylinositol 3-Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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