Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

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Phosphoinositides in cell regulation and membrane dynamics

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The PI3K Pathway in Human Disease

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Comprehensive Characterization of Cancer Driver Genes and Mutations

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The emerging mechanisms of isoform-specific PI3K signalling

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Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia

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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

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Architecture of the human interactome defines protein communities and disease networks

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211 · see citing works

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent <i>in vivo</i> antitumor activity

Maira, S.-M., Stauffer, F., Brueggen, J., Furet, P., Schnell, C., Fritsch, C., Brachmann, S., Chène, P., De Pover, A., Schoemaker, K., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0017 · Cited by 1,134 · see citing works

PI3Kγ is a molecular switch that controls immune suppression

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mTOR kinase structure, mechanism and regulation

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PI3K signalling: the path to discovery and understanding

Vanhaesebroeck, B., Stephens, L., & Hawkins, P. T. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3290 · Cited by 991 · see citing works

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

Lee, Y.-R., Chen, M., & Pandolfi, P. P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0015-0 · Cited by 917 · see citing works

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

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A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

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Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

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The Identification of 2-(1 H -Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2- d ]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

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De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes

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Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

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CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

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Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Hopkins, B. D., Pauli, C., Du, X., Wang, D. G., Li, X., Wu, D., Amadiume, S. C., Goncalves, M. D., Hodakoski, C., Lundquist, M. R., et al. (2018) · Nature · doi:10.1038/s41586-018-0343-4 · Cited by 706 · see citing works

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

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Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

Lucas, C. L., Kuehn, H. S., Zhao, F. R., Niemela, J. E., Deenick, E. K., Palendira, U., Avery, D. T., Moens, L., Cannons, J. L., Biancalana, M., et al. (2013) · Nature Immunology · doi:10.1038/ni.2771 · Cited by 677 · see citing works

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

Chong, L. D., Traynor‐Kaplan, A., Bokoch, G., & Schwartz, M. A. (1994) · Cell · doi:10.1016/0092-8674(94)90259-3 · Cited by 641 · see citing works

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Angulo, I., Vadas, O., Garçon, F., Banham-Hall, E., Plagnol, V., Leahy, T. R., Baxendale, H., Coulter, T. I., Curtis, J. W., Wu, C., et al. (2013) · Science · doi:10.1126/science.1243292 · Cited by 639 · see citing works

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

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PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER–plasma membrane contacts

Chung, J., Torta, F. T., Masai, K., Lucast, L. J., Czapla, H., Tanner, L. B., Narayanaswamy, P., Wenk, M. R., Nakatsu, F., & Camilli, P. V. D. (2015) · Science · doi:10.1126/science.aab1370 · Cited by 620 · see citing works

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

Pacold, M. E., Suire, S., Perišić, O., Lara‐González, S., Davis, C. T., Walker, E. H., Hawkins, P. T., Stephens, L., Eccleston, J. F., & Williams, R. L. (2000) · Cell · doi:10.1016/s0092-8674(00)00196-3 · Cited by 603 · see citing works

Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

Gupta, S., Ramjaun, A. R., Haiko, P., Wang, Y., Warne, P. H., Nicke, B., Nye, E. L., Stamp, G., Alitalo, K. K., & Downward, J. (2007) · Cell · doi:10.1016/j.cell.2007.03.051 · Cited by 589 · see citing works

Targeted therapy in patients with PIK3CA-related overgrowth syndrome

Venot, Q., Blanc, T., Hadj-Rabia, S., Berteloot, L., Ladraa, S., Huyen, J. D. V., Blanc, E., Johnson, S. C., Hoguin, C., Boccara, O., et al. (2018) · Nature · doi:10.1038/s41586-018-0217-9 · Cited by 588 · see citing works

The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations

Huang, C., Mandelker, D. L., Schmidt‐Kittler, O., Samuels, Y., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., Gabelli, S. B., & Amzel, L. M. (2007) · Science · doi:10.1126/science.1150799 · Cited by 564 · see citing works

PTEN-deficient cancers depend on PIK3CB

Wee, S., Wiederschain, D., Maira, S.-M., Loo, A. T., Miller, C., deBeaumont, R. S., Stegmeier, F. P., Yao, Y.-M., & Christoph Lengauer, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802655105 · Cited by 545 · see citing works

PI3K signalling in inflammation

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ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

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Somatic Mosaic Activating Mutations in PIK3CA Cause CLOVES Syndrome

Kurek, K. C., Luks, V. L., Ayturk, U. M., Alomari, A. I., Fishman, S. J., Spencer, S. A., Mulliken, J. B., Bowen, M. E., Yamamoto, G. L., Kozakewich, H. P., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.05.006 · Cited by 533 · see citing works

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

Walker, E. H., Perišić, O., Ried, C., Stephens, L., & Williams, R. L. (1999) · Nature · doi:10.1038/46319 · Cited by 501 · see citing works

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

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Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment

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Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

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High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Cheung, L. W. T., Hennessy, B. T., Li, J., Yu, S., Myers, A. P., Djordjevic, B., Lu, Y., Stemke‐Hale, K., Dyer, M. D., Zhang, F., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0039 · Cited by 469 · see citing works

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

Patrucco, E., Notte, A., Barberis, L., Selvetella, G., Maffei, A., Brancaccio, M., Marengo, S., Russo, G., Azzolino, O., Rybalkin, S. D., et al. (2004) · Cell · doi:10.1016/j.cell.2004.07.017 · Cited by 465 · see citing works

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

Okkenhaug, K. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095946 · Cited by 446 · see citing works

Targeting Plasmodium PI(4)K to eliminate malaria

McNamara, C. W., Lee, M., Lim, C. S., Lim, S. H., Roland, J. T., Nagle, A. S., Simon, O., Yeung, B. K. S., Chatterjee, A. K., McCormack, S., et al. (2013) · Nature · doi:10.1038/nature12782 · Cited by 435 · see citing works

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

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Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

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Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

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PI3Kδ and primary immunodeficiencies

Lucas, C. L., Chandra, A., Nejentsev, S., Condliffe, A. M., & Okkenhaug, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.93 · Cited by 342 · see citing works

Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complex

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Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

Lindhurst, M. J., Parker, V., Payne, F., Sapp, J. C., Rudge, S. A., Harris, J. R., Witkowski, A. M., Zhang, Q., Groeneveld, M. P., Scott, C. E., et al. (2012) · Nature Genetics · doi:10.1038/ng.2332 · Cited by 326 · see citing works

PIP5K-driven PtdIns(4,5) P 2 synthesis: regulation and cellular functions

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RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

Fritsch, R., de Krijger, I., Fritsch, K., George, R., Reason, B., Kumar, M. S., Diefenbacher, M. E., Stamp, G., & Downward, J. (2013) · Cell · doi:10.1016/j.cell.2013.04.031 · Cited by 309 · see citing works

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E. M., Shpiro, N., Ward, R. A., Cross, D. A. E., Ganley, I. G., et al. (2014) · Biochemical Journal · doi:10.1042/bj20140889 · Cited by 305 · see citing works

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α ( <i>PIK3CA</i> )

Burke, J. E., Perisic, O., Masson, G. R., Vadas, O., & Williams, R. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205508109 · Cited by 300 · see citing works

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

Vadas, O., Burke, J. E., Zhang, X., Berndt, A., & Williams, R. L. (2011) · Science Signaling · doi:10.1126/scisignal.2002165 · Cited by 299 · see citing works

A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

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Effective “activated PI3Kδ syndrome”–targeted therapy with the PI3Kδ inhibitor leniolisib

Rao, V. K., Webster, S., Dalm, V. A. S. H., Šedivá, A., van Hagen, P. M., Holland, S. M., Rosenzweig, S. D., Christ, A. D., Sloth, B., Cabanski, M., et al. (2017) · Blood · doi:10.1182/blood-2017-08-801191 · Cited by 297 · see citing works

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

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Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K

Lucas, C. L., Zhang, Y., Venida, A. C., Wang, Y., Hughes, J. D., McElwee, J. J., Butrick, M., Matthews, H. F., Price, S. M., Biancalana, M., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20141759 · Cited by 295 · see citing works

A human immunodeficiency caused by mutations in the PIK3R1 gene

Deau, M., Heurtier, L., Frange, P., Suárez, F., Bôle‐Feysot, C., Nitschké, P., Cavazzana, M., Pïcard, C., Durandy, A., Fischer, A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75746 · Cited by 289 · see citing works

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

Jaiswal, B. S., Janakiraman, V., Kljavin, N. M., Chaudhuri, S., Stern, H. M., Wang, W., Kan, Z., Dbouk, H. A., Peters, B. A., Waring, P., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.016 · Cited by 288 · see citing works

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

Miller, S., Tavshanjian, B., Oleksy, A., Perišić, O., Houseman, B. T., Shokat, K. M., & Williams, R. L. (2010) · Science · doi:10.1126/science.1184429 · Cited by 288 · see citing works

Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)

Fan, W., Nassiri, A., & Zhong, Q. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016472108 · Cited by 285 · see citing works

PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity

Nakatsu, F., Baskin, J. M., Chung, J., Tanner, L. B., Shui, G., Lee, S. Y., Pirruccello, M., Hao, M., Ingolia, N. T., Wenk, M. R., et al. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201206095 · Cited by 277 · see citing works

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

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Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy

Okkenhaug, K., Graupera, M., & Vanhaesebroeck, B. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0716 · Cited by 264 · see citing works

BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models

Liu, N., Rowley, B. R., Bull, C. O., Schneider, C., Haegebarth, A., Schatz, C. A., Fracasso, P. R., Wilkie, D. P., Hentemann, M. F., Wilhelm, S. M., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0993-t · Cited by 263 · see citing works

PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models

Winkler, D. G., Faia, K. L., DiNitto, J. P., Ali, J. A., White, K., Brophy, E. E., Pink, M. M., Proctor, J., Lussier, J., Martin, C. M., et al. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.09.017 · Cited by 262 · see citing works

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Kato, N., Comer, E., Sakata, T., Sharma, A., Sharma, M., Maetani, M., Bastien, J., Brancucci, N. M. B., Bittker, J. A., Corey, V. C., et al. (2016) · Nature · doi:10.1038/nature19804 · Cited by 255 · see citing works

Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer

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Structural Insights into Assembly and Regulation of the Plasma Membrane Phosphatidylinositol 4-Kinase Complex

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Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons

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Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

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PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

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GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

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Structural basis of nSH2 regulation and lipid binding in PI3Kα

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The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis

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Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization

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Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex

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Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

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Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology

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Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein

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Structural and Membrane Binding Analysis of the Phox Homology Domain of Phosphoinositide 3-Kinase-C2α

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Selective Inhibition of Phosphoinositide 3-Kinase p110α Preserves Lymphocyte Function*

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Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

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Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

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The crystal structure of the phosphatidylinositol 4‐kinase IIα

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Exploring phosphatidylinositol 5-phosphate 4-kinase function

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Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles

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Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα

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Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module

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Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled

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Phosphoinositides and host–pathogen interactions

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PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells

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A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation

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The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3

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Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein.

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Structural analysis of phosphatidylinositol 4-kinase IIIβ (PI4KB) – 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro

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Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta

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Crystal Structure of the C2 Domain of Class II Phosphatidylinositide 3-Kinase C2α

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Mechanism of substrate specificity of phosphatidylinositol phosphate kinases

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Molecular Basis for Association of PIPKIγ-p90 with Clathrin Adaptor AP-2

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Development of First Lead Structures for Phosphoinositide 3-Kinase-C2γ Inhibitors

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The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design

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Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins

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PI(4)P homeostasis: Who controls the controllers?

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Isoform-Selective Phosphatidylinositol 3-Kinase Inhibition in Cancer

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Targeting PI3K/Akt signal transduction for cancer therapy

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PI3K isoforms in cell signalling and vesicle trafficking

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PI3K inhibitors are finally coming of age

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Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

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Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme

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The present and future of PI3K inhibitors for cancer therapy

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Recent advances in activity-based probes (ABPs) and affinity-based probes (A f BPs) for profiling of enzymes

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Novel roles of phosphoinositides in signaling, lipid transport, and disease

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PI3K/Akt/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment

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Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane

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The Opposing Roles of PIK3R1/p85α and PIK3R2/p85β in Cancer

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Clinical, Immunological, and Genetic Features in Patients with Activated PI3Kδ Syndrome (APDS): a Systematic Review

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Beyond PI3Ks: targeting phosphoinositide kinases in disease

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Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease

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Current State and Future Challenges for PI3K Inhibitors in Cancer Therapy

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Optimal targeting of PI3K-AKT and mTOR in advanced oestrogen receptor-positive breast cancer

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Targeting PI3K signaling in cancer: Challenges and advances

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The 3.2-Å resolution structure of human mTORC2

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The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke

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Defining the subcellular distribution and metabolic channeling of phosphatidylinositol

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Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities

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Naturally occurring T cell mutations enhance engineered T cell therapies

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Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells

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Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies

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PI3K inhibitors in thrombosis and cardiovascular disease

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Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus

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The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases

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Kinase Inhibitors as Underexplored Antiviral Agents

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PI4P/PS countertransport by ORP10 at ER–endosome membrane contact sites regulates endosome fission

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Lipid metabolism and identification of biomarkers in asthma by lipidomic analysis

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ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors

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A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion

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Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility

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Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides

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The membrane surface as a platform that organizes cellular and biochemical processes

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Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca 2+ efflux and disrupted by PSEN1 loss of function

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Phosphoinositide 3-kinase (PI3K) classes: From cell signaling to endocytic recycling and autophagy

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Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

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BiallelicPI4KAvariants cause a novel neurodevelopmental syndrome with hypomyelinating leukodystrophy

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