An intrinsic rhythm of urinary calcium excretion and the specific effect of bedrest on the excretory pattern
Abstract
1. The diurnal rhythms of urinary calcium excretion were studied in healthy subjects under four different regimens in which diet, activity and posture were varied. The excretory rhythms observed were compared with those of potassium, obtained under the same conditions. 2. When the subjects were active throughout the day and night and were either fasting or eating standard three-hourly meals, an intrinsic calcium rhythm was isolated with maximum amounts excreted between 06.00 and 09.00 hours. 3. Continuous supine bedrest was found to have a specific effect on calcium excretion. The total 24 h excretion was markedly increased compared with that found on constant activity but on the same dietary regimen, and 78% of the increase occurred between 09.00 and 18.00 hours.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
After several days of inactivity, the endocrine system is altered, characterized by an increase in insulin resistance and alterations in bone metabolism, with increased calcium excretion and bone resorption.
“The endocrine system is also altered after several days of inactivity, characterized by an increase in insulin resistance and alterations in bone metabolism, with the latter resulting in increased calcium excretion and bone resorption.32,33”
From Society for Maternal-Fetal Medicine Consult Series #50: The role of activity restriction in obstetric management (2020) · cites this paper as [33]
Cites
Effects of immobilization upon various metabolic and physiologic functions of normal men
Deitrick, J. E., Whedon, G. D., & Shorr, E. (1948) · The American Journal of Medicine · doi:10.1016/0002-9343(48)90370-2 · Cited by 614 · see citing works
Mills, J. N. (1966) · Physiological Reviews · doi:10.1152/physrev.1966.46.1.128 · Cited by 487 · see citing works
ELECTROLYTE EXCRETION IN RELATION TO DIURNAL CYCLES OF RENAL FUNCTION
Wesson, L. G. (1964) · Medicine · doi:10.1097/00005792-196409000-00002 · Cited by 175 · see citing works
Effect of prolonged bed rest on urinary calcium output.
Issekutz, B., Jr., Blizzard, J. J., Birkhead, N. C., & Rodahl, K. (1966) · Journal of Applied Physiology · doi:10.1152/jappl.1966.21.3.1013 · Cited by 152 · see citing works
Diurnal variation in electrolyte excretion.
Stanbury, S., & Thomson, A. E. (1951) · PubMed · Cited by 151 · see citing works
Effects of Recumbency and Space Flight on Bone Density
Mack, P. B., & LaChance, P. C.-I. (1967) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/20.11.1194 · Cited by 75 · see citing works
Lewis, P. R., & Lobban, M. C. (1957) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1957.sp001280 · Cited by 59 · see citing works
DIURNAL VARIATION IN URINARY EXCRETION OF CALCIUM AND PHOSPHATE AND ITS RELATION TO BLOOD LEVELS.
Carruthers, B. M., Dh, C., & Hw, M. (1964) · PubMed · Cited by 53 · see citing works
Lewis, P. R., & Lobban, M. C. (1956) · The Journal of Physiology · doi:10.1113/jphysiol.1956.sp005617 · Cited by 47 · see citing works
Heaton, F. W., & Hodgkinson, A. J. (1963) · Clinica Chimica Acta · doi:10.1016/0009-8981(63)90164-5 · Cited by 45 · see citing works
A POSSIBLE EXPLANATION FOR CUSHING'S SYNDROME ASSOCIATED WITH ADRENAL HYPERPLASIA*
Nugent, C. A., Eik‐Nes, K. B., KENT, H. S., Samuels, L. T., & Tyler, F. H. (1960) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-20-9-1259 · Cited by 45 · see citing works
Hk, M., Jones, J. E., & Flink, E. B. (1966) · PubMed · Cited by 37 · see citing works
METABOLISM OF FREE AND CONJUGATED 17-HYDROXYCORTICOSTEROIDS IN NORMAL SUBJECTS*
Brown, H., Englert, E., Wallach, S., & Simons, E. L. (1957) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-17-10-1191 · Cited by 34 · see citing works
Diurnal variations in calcium and magnesium excretion in man
Briscoe, A. M., & Ragan, C. A. (1966) · Metabolism · doi:10.1016/0026-0495(66)90048-5 · Cited by 24 · see citing works
A reciprocal relationship between K+ and H+ excretion in the diurnal excretory rhythm in man.
Jn, M., & Sw, S. (1954) · PubMed · Cited by 19 · see citing works
Reappearance of renal excretory rhythm after forced disruption
Mills, J. N., Thomas, S., & Yates, P. A. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005173 · Cited by 17 · see citing works
Diurnal variation in urinary excretion of calcium and strontium
Loutit, J. F. (1965) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1965.0050 · Cited by 15 · see citing works
Contribution of activity to the circadian rhythm in excretion of magnesium and calcium.
Fiorica, V. M., Burr, M. J., & Moses, R. (1968) · PubMed · Cited by 8 · see citing works
Effects of intravenous injections of calcium laevulinate on calcium and phosphate metabolism.
Birkenhäger, W. H., Hellendoorn, H. B. A., & Gerbrandy, J. (1959) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Fuleihan, G. E., Klerman, E. B., Brown, E. N., Choe, Y. S., Brown, E. M., & Czeisler, C. A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.1.3683 · Cited by 148 · see citing works
Calvo, M. S., Eastell, R., Offord, K. P., Bergstralh, E. J., & Burritt, M. F. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-1-69 · Cited by 136 · see citing works
The Circadian Clock in the Regulation of Renal Rhythms
Solocinski, K., & Gumz, M. L. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415610879 · Cited by 94 · see citing works
Maternal activity restriction and the prevention of preterm birth
Sciscione, A. C. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.07.005 · Cited by 79 · see citing works
Parry, E. S., & Lister, I. S. (1975) · The Lancet · doi:10.1016/s0140-6736(75)91830-9 · Cited by 78 · see citing works
Osteoporosis: Pathogenesis and Therapy
Avioli, L. V. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-068701-5.50012-9 · Cited by 77 · see citing works
New insights in regulation of calcium homeostasis
Felsenfeld, A. J., Rodríguez, M., & Levine, B. (2013) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328362141e · Cited by 59 · see citing works
Urinary calcium excretion in healthy children and adolescents
Manz, F., Kehrt, R., Lausen, B., & Merkel, A. (1999) · Pediatric Nephrology · doi:10.1007/s004670050723 · Cited by 51 · see citing works
Serum Concentration of 1,25-Dihydroxyvitamin D in the Human: Diurnal Variation*
Halloran, B. P., Portale, A. A., de Castro, M., Morris, R. C., & Goldsmith, R. S. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-6-1104 · Cited by 49 · see citing works
Lauder, J., Sciscione, A., Biggio, J., & Osmundson, S. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.04.031 · Cited by 46 · see citing works
�ber Reproduzierbarkeit circadianer Rhythmen beim Menschen
Aschoff, J., & Wever, R. A. (1980) · Journal of Molecular Medicine · doi:10.1007/bf01477275 · Cited by 31 · see citing works
Effects of Inactivity on Bone and Calcium Metabolism
Arnaud, S. B., SCHNEIDER, V., & Morey, E. R. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-618510-2.50007-5 · Cited by 28 · see citing works
Disruption of circadian rhythm as a potential pathogenesis of nocturia
Song, Q., Suadicani, S. O., Negoro, H., Jiang, H., Jabr, R. I., Fry, C. H., Xue, W., & Damaser, M. S. (2024) · Nature Reviews Urology · doi:10.1038/s41585-024-00961-0 · Cited by 24 · see citing works
The renal molecular clock: broken by aging and restored by exercise
Schmitt, E. E., Johnson, E. C., Yusifova, M., & Bruns, D. R. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00301.2019 · Cited by 22 · see citing works
MCCARTY-SINGLETON, S., & SCISCIONE, A. C. (2014) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000048 · Cited by 19 · see citing works
Jm, M.-M., Dequeker, J., & Gevers, G. (1988) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(88)80005-0 · Cited by 19 · see citing works
Circadian regulation of kidney function: finding a role for Bmal1
Zhang, D., & Pollock, D. M. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00580.2017 · Cited by 18 · see citing works
Psychosocial and Chronophysiological Effects Of Inactivity and Immobilization
Winget, C. M., & DEROSHIA, C. W. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-618510-2.50010-5 · Cited by 12 · see citing works
Walker, A. R. P., Walker, B. F., & Wadvalla, M. (1975) · Ecology of Food and Nutrition · doi:10.1080/03670244.1975.9990418 · Cited by 9 · see citing works
Extracellular calcium homeostasis
Perault-Staub, A. M., Staub, J. F., & MILHAUD, G. (1990) · Elsevier eBooks · doi:10.1016/b978-0-444-81371-8.50007-8 · Cited by 8 · see citing works
Aschoff, J. (1973) · Verhandlungen der Deutschen Gesellschaft für Innere Medizin · doi:10.1007/978-3-642-47087-5_4 · Cited by 6 · see citing works
Clinical Physiology: Urinary Excretion of Hydroxyprolines in Man under the Influence of Cold
Lennquist, S. (1975) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365517509087212 · Cited by 5 · see citing works
The Kidney and Hormones Affecting it
Minors, D. S., & Waterhouse, J. M. (1981) · Elsevier eBooks · doi:10.1016/b978-0-7236-0592-8.50010-7 · Cited by 5 · see citing works
Sixty Days in a Submarine: The Pathophysiological and Metabolic Cost
Davies, D. M. (1973) · Journal of the Royal College of Physicians of London · doi:10.1016/s0035-8819(25)03192-7 · Cited by 3 · see citing works
Skeletal disease in the elderly.
Leeming, J. T. (1973) · BMJ · doi:10.1136/bmj.4.5890.472 · Cited by 3 · see citing works
P60. Effect of calcium supplementation on the circadian rhythm of bone resorption
Blumsohn, A., Al-Dehaimi, A., Herrington, K. A., Shao, P., Eyre, D., & Eastell, R. (1994) · Bone · doi:10.1016/8756-3282(94)90793-5 · Cited by 1 · see citing works
The Impact of Activity Restriction on Obstetric Management
O'Sullivan, C., & Sciscione, A. C. (2026) · Topics in Obstetrics & Gynecology · doi:10.1097/01.pgo.0001240828.58381.9b
- Authors
- Ede, M. C. M., Faulkner, M. H., & Tredre, B. E.
- Affiliations
- Department of Physiology, Guy's Hospital Medical School, London
- Guy's Hospital (GB)
- National Institute for Medical Research (GB)
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1972-04-01
- Volume
- 42
- Issue
- 4
- Pages
- 433-445
- ISSN
- 0009-9287 (ISSN-L)
- OpenAlex
- W2303675933
- Cited by
- 27
- References
- 19
- Citations by year
- 2026: 1 · 2024: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Kidney Stones and Urolithiasis Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- urinary calcium excretion, diurnal cycle, bed rest, potassium excretion, physical activity, posture, fasting, meal timing, circadian rhythm
- MeSH terms
- Adult, Calcium, Circadian Rhythm, Diet, Fasting, Humans, Male, Posture, Potassium, Rest
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
