Stimulatory action of parathyroid hormone on renin secretion in vitro: a study using isolated rat kidney, isolated rabbit glomeruli and superfused dispersed rat juxtaglomerular cells
Abstract
1. We have previously reported that pharmacological concentrations (125 nmol/l) of parathyroid hormone may stimulate renin release in the stable recirculating and non-filtering isolated rat kidney. 2. In the present study we have attempted to extend these initial observations by examining the concentration-related response of renin release to parathyroid hormone, using the same model of isolated kidney, and determining whether the effect of parathyroid hormone on renin release can be demonstrated by more direct approaches. Thus, the effects of parathyroid hormone on renin secretion were investigated in two other renal preparations: isolated rabbit glomeruli and isolated rat juxtaglomerular cells. 3. In the isolated kidney, rat parathyroid hormone significantly stimulated renin accumulation in the perfusate in a concentration-related manner with a threshold of 1 nmol/l. 4. In both glomeruli and juxtaglomerular cells bovine [Nle8,18,Tyr34]parathyroid hormone-(1–34)amide effectively and repeatedly stimulated renin release. These results imply that there is a direct stimulatory effect of parathyroid hormone on renin release. 5. We also examined the effect of [Nle8,18, Tyr34]parathyroid hormone-(l-34)amide during extracellular calcium buffering in the glomeruli. [Nle8,18,Tyr34]parathyroid hormone-(1–34)amide was uneffective in calcium-free medium. Increasing the extracellular ionized calcium concentration to 2.5 mmol/l increased the extent of stimulation in accordance with the reported ability of parathyroid hormone to block calcium channels and relax vascular smooth muscle cells. 6. These results provide further support for the role of parathyroid hormone as a direct mediator of renin secretion; moreover, the renin-stimulating action of parathyroid hormone may be mediated through the inhibition of calcium influx.s
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The renin–angiotensin–aldosterone system and calcium-regulatory hormones
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Parathyroid hormone and the risk of incident hypertension
Taylor, E. N., Curhan, G. C., & Forman, J. P. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282ffb43b · Cited by 75 · see citing works
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Self-citationThe Interplay Between the Renin-Angiotensin-Aldosterone System and Parathyroid Hormone
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“reported that the renin stimulation of PTH may be mediated by the inhibition of calcium influx (106); however, a study by Hulter et al.”
ResultHuman kidney organoids produce functional renin
Shankar, A., Du, Z., Mora, H. T., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.08.008 · Cited by 57 · see citing works
Regulation of Renin Release by Local and Systemic Factors
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Renin-angiotensin-aldosterone system in primary hyperparathyroidism before and after surgery
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“These human studies corroborate in-vitro evidence of direct stimulation of renin by PTH [21,76] (Fig.”
BackgroundResultSAUSSINE, C., Massfelder, T., Parnin, F., et al. (1993) · Kidney International · doi:10.1038/ki.1993.311 · Cited by 37 · see citing works
Self-citationFritsch, S., Lindner, V., Welsch, S., Massfelder, T., Grima, M., Rothhut, S., Barthelmebs, M., & Helwig, J. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000141040.77536.af · Cited by 31 · see citing works
“PTH(1-34) not only vasodilates the kidney in vitro (3) and in vivo (4) but also has been proved to stimulate the release of renin activity in vitro (5).”
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Self-citationPostmenopausal osteoporosis is associated with elevated aldosterone/renin ratio
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“However, one study found PTH directly stimulated renin in vitro [23], but the association between PTH and renin was not observed in previous human studies [17, 24] or in the present study.”
ResultDevelopmental aspects of parathyroid hormone-related protein biology
Escande, B., Lindner, V., Massfelder, T., et al. (2001) · Seminars in Perinatology · doi:10.1053/sper.2001.23194 · Cited by 14 · see citing works
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Prognostic Value of Serum Parathyroid Hormone Level in Acute Decompensated Heart Failure
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“Further- more, PMSF stimulated renin release in the absence of PTH, suggesting that the stimulatory effect of their preparation on renin release was solely due to the presence of PMSF (34).”
BackgroundResultInfluentialDobreva, E. A., Евгеньевна, Б. Е., Константиновна, Е. А., Rebrova, O. Y., Nikankina, L. V., Malysheva, N. M., & Mokrysheva, N. G. (2020) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2019-25-6-630-638 · Cited by 5 · see citing works
Dobreva, E. A., Bibik, E. E., Eremkina, A. K., Ajnetdinova, A. R., Nikankina, L. V., Malysheva, N. M., & Mokrysheva, N. G. (2020) · Terapevticheskii Arkhiv · doi:10.26442/00403660.2020.10.000725 · Cited by 4 · see citing works
“При введении рекомбинантного ПТГ показана аналогичная стимуляция выработки ренина [16, 17].”
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- Authors
- Saussine, C., Judes, C., Massfelder, T., Musso, M.-J., Simeoni, U., Hannedouche, T., & Helwig, J.-J.
- Affiliations
- Université de Strasbourg (FR)
- Laboratoire de Physiologie Cellulaire Rénale, Université Louis Pasteur, Strasbourg, France
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1993-01-01
- Volume
- 84
- Issue
- 1
- Pages
- 11-19
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2407165539
- Cited by
- 32
- References
- 0
- Citations by year
- 2020: 6 · 2019: 2 · 2018: 1 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- parathyroid hormone, renin secretion, juxtaglomerular cells, glomeruli, isolated kidney, parathyroid hormone fragments, ionized calcium, calcium influx inhibition, concentration-dependent effects
- MeSH terms
- Animals, Calcium, Cells, Cultured, Dose-Response Relationship, Drug, Juxtaglomerular Apparatus, Kidney, Kidney Glomerulus, Male, Organ Culture Techniques, Parathyroid Hormone, Peptide Fragments, Rabbits, Renin, Stimulation, Chemical, Rats, Wistar, Teriparatide, Rats
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