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Cited by 128Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlCardiovascular and exercise physiology

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Effects of Leg Muscle Pumping and Tensing on Orthostatic Arterial Pressure: A Study in Normal Subjects and Patients with Autonomic Failure

Ten Harkel, A. D. J., Van Lieshout, J. J., Wieling, W.·1994·Clinical Science
DOI 10.1042/cs0870553
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Abstract

1. The effects of leg muscle pumping (tiptoeing) and tensing (leg-crossing) on orthostatic blood pressure were investigated in six healthy adult subjects (aged 28–34 years) and in seven patients with severe hypoadrenergic orthostatic hypotension (aged 20–65 years). 2. Finger arterial pressure was monitored. Relative changes in left ventricular stroke volume were computed by a pulse contour method. 3. Tiptoeing increased mean arterial pressure (7 ± 5 mmHg) in the healthy subjects, but not in the patients, whereas cardiac output increased in both groups, although by more in the healthy adults than in the patients (35 ± 10% versus 20 ± 11%, P < 0.05). Systemic vascular resistance decreased substantially in both groups while tiptoeing. Leg-crossing did not affect arterial pressure in the healthy subjects, although stroke volume had increased. In contrast, in the patients an increase in cardiac output (16 ± 12%) and mean blood pressure (13 ± 13 mmHg) was observed. 4. Tiptoeing and leg-crossing have different effects on orthostatic blood pressure in healthy adult subjects and in patients with autonomic failure. In normal humans, tiptoeing increases arterial pressure, whereas leg-crossing has little effect. In the patients, in contrast, tiptoeing has little effect, whereas leg-crossing increases arterial pressure considerably. Patients with autonomic failure should be instructed to apply leg-crossing to combat orthostatic dizziness.

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Crossref · 10.1042/cs0870553

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1 of 1 references verified0 citation errors · 0 not checkable

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  • Studies attempting to decrease orthostatic hypotension due to autonomic failure noted that a small increase in blood pressure produced considerable improvements in orthostatic tolerance.

    “Studies attempting to decrease orthostatic hypotension due to autonomic failure (e.g., ten Harkel et al., 1994; van Lieshout et al., 1992) noted that a small increase in BP produced considerable improvements in orthostatic tolerance.”

    From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as ten Harkel et al., 1994

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Metadata

Authors
Ten Harkel, A. D. J., Van Lieshout, J. J., & Wieling, W.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • 2Department of Medicine, Academic Medical Centre, Amsterdam, The Netherlands
ORCID
Venue
Clinical Science
Publisher
Portland Press Ltd.
Published
1994-11-01
Volume
87
Issue
5
Pages
553-558
ISSN
  • 0143-5221 (ISSN-L)
  • 1470-8736
DOI
10.1042/cs0870553
OpenAlex
W3334212
Cited by
128
References
1
Citations by year
2025: 8 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 14 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 5
FWCI
0.60
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Science (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
orthostatic hypotension, autonomic failure, leg crossing, orthostatic blood pressure, cardiac output, stroke volume, systemic vascular resistance, orthostatic dizziness, postural blood pressure
MeSH terms
Adult, Aged, Autonomic Nervous System Diseases, Blood Pressure, Cardiac Output, Female, Heart Rate, Humans, Hypotension, Orthostatic, Leg, Male, Middle Aged, Muscle Contraction, Stroke Volume, Supine Position, Muscle, Skeletal

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