Factors determining cardiac hypertrophy in hypertensive patients with or without peripheral vascular disease
Abstract
1. Coronary ischaemic disease and congestive heart failure are the principal causes of mortality in patients with peripheral vascular disease. Whether cardiac hypertrophy is present and even more pronounced in peripheral vascular disease than in other populations has never been explored.2.Twenty-five hypertensive patients were investigated, 11 without and 14 with peripheral vascular disease, matched for age, sex, mean arterial pressure and antihypertensive drug treatment. Cardiac mass was determined using echocardiography together with measurement of systemic blood pressure, ratio between ankle systolic pressure (ASP) and brachial systolic pressure (BSP), and standard biochemical parameters including natriuresis per 24 h.3. At the same mean arterial pressure, patients with peripheral vascular disease had a significantly higher cardiac mass (157+/-12 versus 116+/-6 g/m2; P<0.01), pulse pressure (81+/-5 versus 55+/-4 mmHg; P<0.01) and natriuresis (180+/-17 versus 144+/-6 mmol/24h; P<0. 01) than controls. Using univariate correlations, cardiac mass was positively associated with pulse pressure, mean arterial pressure and natriuresis, and negatively with the ASP/BSP ratio. On the basis of multivariate regression analysis, only natriuresis was positively correlated to cardiac mass.4. Patients with peripheral vascular disease develop a higher degree of cardiac hypertrophy in comparison with hypertensive subjects with the same level of mean arterial pressure. Sodium intake rather than mechanical factors seems to be the major modulating factor which influences the degree of cardiac hypertrophy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Patients with hypertension who have peripheral vascular disease have a greater degree of LVH than those without LVH.
“Indeed, it is known that patients with hypertension who have peripheral vascular disease have a greater degree of LVH than those without LVH (20)”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [20]
Cites
The prevalence of peripheral arterial disease in a defined population.
Criqui, M. H., Fronek, A. S., Barrett-Connor, E. L., Klauber, M. R., GABRIEL, S., & Goodman, D. (1985) · Circulation · doi:10.1161/01.cir.71.3.510 · Cited by 1,083 · see citing works
Ankle systolic pressure measurements in arterial disease affecting the lower extremities
Yao, S. T., Hobbs, J. T., & Irivne, W. T. (1969) · Journal of British Surgery · doi:10.1002/bjs.1800560910 · Cited by 542 · see citing works
Criqui, M. H., Coughlin, S. S., & Fronek, A. (1985) · Circulation · doi:10.1161/01.cir.72.4.768 · Cited by 156 · see citing works
Pulse pressure and echocardiographic findings in essential hypertension
Pannier, B., Brunei, P., Aroussy, W. E., Lacolley, P. J., & Safar, M. E. (1989) · Journal of Hypertension · doi:10.1097/00004872-198902000-00008 · Cited by 117 · see citing works
Self-citationArterial dynamics, cardiac hypertrophy, and antihypertensive treatment.
Safar, M. E., Toto-Moukouo, J. J., Bouthier, J. A., Asmar, R. G., Levenson, J. A., Simon, A. C., & London, G. M. (1987) · PubMed · Cited by 105 · see citing works
Self-citationRole of sodium in hypertensive cardiac hypertrophy.
Lindpaintner, K., & Sen, S. (1985) · Circulation Research · doi:10.1161/01.res.57.4.610 · Cited by 58 · see citing works
Epidemiology of systolic and diastolic systemic blood pressure elevation in the elderly
Schoenberger, J. A. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)91026-x · Cited by 31 · see citing works
Increased pulse pressure in patients with arteriosclerosis obliterans of the lower limbs.
Safar, M. E., Toto-Moukouo, J. J., Asmar, R., et al. (1987) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.7.3.232 · Cited by 30 · see citing works
Self-citationLevenson, J., Simon, A., Maarek, B. E., Gitelman, R. J., Fiessinger, J., & Safar, M. (1985) · Arteriosclerosis · doi:10.1161/01.atv.5.1.80 · Cited by 30 · see citing works
Self-citationLevenson, J., Simon, A. C., Fiessinger, J., et al. (1982) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.2.3.266 · Cited by 22 · see citing works
Salt intake as a determinant of cardiac hypertrophy.
Ah, B., & Schmieder, R. (1995) · PubMed · Cited by 16 · see citing works
Hugues, C., Asmar, R. G., London, G. M., et al. (1988) · Angiology · doi:10.1177/000331978803900303 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive
Greenwood, J. P., Scott, E. M., Stoker, J. B., & Mary, D. A. S. G. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01600-x · Cited by 161 · see citing works
- Authors
- BRAHIMI, M., LEVY, B. I., SAFAR, M. E., & DABIRÉ, H.
- Affiliations
- Hôpital Lariboisière (FR)
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1998-09-01
- Volume
- 95
- Issue
- 3
- Pages
- 261-267
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2084480592
- Cited by
- 9
- References
- 12
- Citations by year
- 2017: 2 · 2015: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- cardiac hypertrophy, hypertension, peripheral vascular disease, cardiac mass, sodium excretion, pulse pressure, sodium intake, mean arterial pressure, echocardiography
- MeSH terms
- Aged, Blood Pressure Determination, Cross-Sectional Studies, Echocardiography, Electrocardiography, Female, Cardiomegaly, Humans, Hypertension, Male, Middle Aged, Sodium, Sodium, Dietary, Peripheral Vascular Diseases, Statistics, Nonparametric
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
