Induction of osteoclasts from CD14-positive human peripheral blood mononuclear cells by receptor activator of nuclear factor κB ligand (RANKL)

NICHOLSON, Geoffrey C.; MALAKELLIS, Mary; COLLIER, Fiona M.; CAMERON, Paul U.; HOLLOWAY, Wayne R.; GOUGH, Tamara J.; GREGORIO-KING, Claudia; KIRKLAND, Mark A.; MYERS, Damian E.

doi:10.1042/cs0990133

Induction of osteoclasts from CD14-positive human peripheral blood mononuclear cells by receptor activator of nuclear factor κB ligand (RANKL)

Osteoclasts are bone-resorbing cells that are derived from haemopoietic precursors, including cells present in peripheral blood. The recent identification of RANKL [receptor activator of nuclear factor (NF)-κB ligand], a new member of the tumour necrosis factor ligand superfamily that has a key r…