The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
The Cellular and Molecular Biology of Periprosthetic Osteolysis
Abstract
The generation of prosthetic implant wear after total joint arthroplasty is recognized as the major initiating event in development of periprosthetic osteolysis and aseptic loosening, the leading complication of this otherwise successful surgical procedure. We review current concepts of how wear debris causes osteolysis, and report ideas for prevention and treatment. Wear debris primarily targets macrophages and osteoclast precursor cells, although osteoblasts, fibroblasts, and lymphocytes also may be involved. Molecular responses include activation of MAP kinase pathways, transcription factors (including NFkappaB), and suppressors of cytokine signaling. This results in up-regulation of proinflammatory signaling and inhibition of the protective actions of antiosteoclastogenic cytokines such as interferon gamma. Strategies to reduce osteolysis by choosing bearing surface materials with reduced wear properties should be balanced by awareness that reducing particle size may increase biologic activity. There are no approved treatments for osteolysis despite the promise of therapeutic agents against proinflammatory mediators (such as tumor necrosis factor) and osteoclasts (bisphosphonates and molecules blocking receptor activator of NFkappaB ligand [RANKL] signaling) shown in animal models. Considerable efforts are underway to develop such therapies, to identify novel targets for therapeutic intervention, and to develop effective outcome measures.
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Cites
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Ten Years' Experience with Alendronate for Osteoporosis in Postmenopausal Women
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Cited by
On the mechanisms of biocompatibility
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NF-κB signaling and bone resorption
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The Role of Autophagy and Mitophagy in Bone Metabolic Disorders
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Is Peri-Implant Probing Causing Over-Diagnosis and Over-Treatment of Dental Implants?
Coli, P., & Sennerby, L. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081123 · Cited by 55
Metadata
- Authors
- Purdue, P. E., Koulouvaris, P., Potter, H. G., Nestor, B. J., & Sculco, T. P.
- Venue
- Clinical Orthopaedics and Related Research
- Published
- 2007-01
- Volume
- 454
- Pages
- 251-261
- ISSN
- 0009-921X (ISSN-L)
- OpenAlex
- W1983332596
- Cited by
- 372
- References
- 128
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Purdue, P. E., Koulouvaris, P., Potter, H. G., Nestor, B. J., & Sculco, T. P. (2007). The Cellular and Molecular Biology of Periprosthetic Osteolysis. Clinical Orthopaedics and Related Research. https://doi.org/10.1097/01.blo.0000238813.95035.1b
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
