The DOI matches its Crossref record.
Molecular and cellular mechanisms of action of angiotensin II (AT1) receptors in vascular smooth muscle.
Abstract
Angiotensin is an important regulator of blood pressure and exerts both pressor actions and influences growth in the cardiovascular system via the AT1 receptor. This review describes a number of signalling mechanisms involved in vasoconstriction and growth in response to AT1 receptor activation in vascular smooth muscle.
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In the citing paper
“Angiotensin II exerts vasoconstrictor effect (Hughes, 1998).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Hughes, 1998
Citations
Cited by
Beamish, J. A., He, P., Kottke-Marchant, K., & Marchant, R. E. (2010) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2009.0630 · Cited by 383
“The AT1 receptor mediates changes in intracellular calcium that are a major determinant of SMC contraction.(76) Ang-II may stimulate SMC proliferation(83,84) or stimulate hypertrophy without proliferation.”
Angiotensin receptors: distribution, signalling and function
DINH, D. T., FRAUMAN, A. G., JOHNSTON, C. I., & FABIANI, M. E. (2001) · Clinical Science · doi:10.1042/cs1000481 · Cited by 268
Elmarasi, M., Elmakaty, I., Elsayed, B., Elsayed, A., Zein, J. A., Boudaka, A., & Eid, A. H. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31200 · Cited by 169
“While AT1 is primarily implicated inVSMC contraction (Hughes, 1998; Yu et al., 2012), a characteristic of differentiated phenotype, AT2 is known to promote proliferation or hypertrophy of these cells (Chow & Allen, 2016; Lemarié & Schiffrin, 2010; Nguyen Dinh Cat & Touyz, 2011; Ruiz ‐ Ortega et…”
BackgroundTouyz, R. M., He, G., Wu, X., Park, J. B., Mabrouk, M. E., & Schiffrin, E. L. (2001) · Hypertension · doi:10.1161/01.hyp.38.1.56 · Cited by 105
Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation
Lin, C., & Pan, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7408-8 · Cited by 100
Metadata
- Authors
- Hughes, A.
- Venue
- Journal of Human Hypertension
- Published
- 1998-05-01
- Volume
- 12
- Issue
- 5
- Pages
- 275-281
- ISSN
- 0950-9240 (ISSN-L)
- 1476-5527
- OpenAlex
- W1963495404
- Cited by
- 29
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2012: 2
- Type
- other
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
- Locations
- Journal of Human Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- angiotensin II, angiotensin II type 1 receptor, vascular smooth muscle, vasoconstriction, cell growth, signalling mechanisms, blood pressure regulation, hypertension
- MeSH terms
- Angiotensin II, Animals, Cells, Cultured, Humans, Hypertension, Ion Channels, Muscle, Smooth, Vascular, Type C Phospholipases, Protein Kinase C, Receptors, Angiotensin, Vasoconstriction, Signal Transduction, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Molecular and cellular mechanisms of action of angiotensin II (AT1) receptors in vascular smooth muscle. https://app.cochat.ai/papers/10.1038/sj.jhh.1000635
- The paper
- Hughes, A. (1998). Molecular and cellular mechanisms of action of angiotensin II (AT1) receptors in vascular smooth muscle. Journal of Human Hypertension. https://doi.org/10.1038/sj.jhh.1000635
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
