The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation
Abstract
The aim of this cohort study was to determine whether periodontitis and gingivitis are associated with impaired salivary antioxidant status and increased oxidative injury. One hundred and twenty-nine patients attending a routine dental check-up were recruited for the study. Periodontal disease status was characterized using the Community Periodontal Index of Treatment Needs (CPITN) system. Total salivary antioxidant capacity and salivary ascorbate, urate and albumin were determined in a sample of whole unstimulated saliva. Protein carbonyl concentrations were determined as an index of oxidative injury. Patients in the lowest tertile of CPITN score exhibited decreased salivary delivery of antioxidants and specifically urate than patients in the upper tertile. Poor periodontal health was associated with increased concentrations of protein carbonyls in saliva. Women had significantly lower total antioxidant status than men, regardless of periodontal health. Periodontal disease is associated with reduced salivary antioxidant status and increased oxidative damage within the oral cavity.
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Cited by
The role of reactive oxygen and antioxidant species in periodontal tissue destruction
Chapple, I. L. C., & Matthews, J. B. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00178.x · Cited by 936
Dumitru, C. N., Mariana, L., Budacu, C. C., Mitea, G., Radu, M. D., Dumitru, A. O., Lupoae, A., Tatu, A., & Topor, G. (2025) · Dentistry Journal · doi:10.3390/dj13050222 · Cited by 17
Metadata
- Authors
- SCULLEY, D. V., & LANGLEY-EVANS, S. C.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2003-08-01
- Volume
- 105
- Issue
- 2
- Pages
- 167-172
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2015674218
- Cited by
- 261
- References
- 21
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
