The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Toll-like receptor polymorphisms and susceptibility to human disease
Abstract
Although several lines of evidence suggest that variation in human inflammation is genetically controlled, the genes which regulate these responses are largely unknown. TLRs (Toll-like receptors) mediate recognition of microbes, regulate activation of the innate immune response and influence the formation of adaptive immunity. Cellular and molecular studies over the past several years have identified a number of common TLR polymorphisms that modify the cellular immune response and production of cytokines in vitro. In addition, human genetic studies suggest that some of these polymorphisms are associated with susceptibility to a spectrum of diseases. In this review, we summarize studies of common TLR polymorphisms and how this work is beginning to illuminate the influence of human variation on inflammation and disease susceptibility.
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Cites
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Cited by
Molecular pathology of age-related macular degeneration
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“Association with a microbial component triggers upregulation of pro-inflammatory genes such as tissue necrosis factor, interleukin-1b, and interleukin-6, through the NFkB pathway (Misch and Hawn, 2008).”
BackgroundRutkowski, M. R., Stephen, T. L., Svoronos, N., Allegrezza, M. J., Tesone, A. J., Perales-Puchalt, A., Brencicova, E., Escovar-Fadul, X., Nguyen, J. M., Cadungog, M. G., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.009 · Cited by 311
The Control of Adaptive Immune Responses by the Innate Immune System
Schenten, D., & Medzhitov, R. (2011) · Advances in Immunology · doi:10.1016/b978-0-12-387664-5.00003-0 · Cited by 279
Lampropoulou, V., Calderon‐Gomez, E., Roch, T., Neves, P., Shen, P., Stervbo, U., Boudinot, P., Anderton, S. M., & Fillatreau, S. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00855.x · Cited by 130
Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly
George, J., Motshwene, P. G., Wang, H., Kubarenko, A. V., Rautanen, A., Mills, T. C., Hill, A. V. S., Gay, N. J., & Weber, A. N. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159996 · Cited by 66
Metadata
- Authors
- Misch, E. A., & Hawn, T. R.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2008-02-01
- Volume
- 114
- Issue
- 5
- Pages
- 347-360
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2079955793
- Cited by
- 263
- References
- 132
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- closed
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