The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cardiovascular effects of air pollution
Abstract
Air pollution is a heterogeneous mixture of gases, liquids and PM (particulate matter). In the modern urban world, PM is principally derived from fossil fuel combustion with individual constituents varying in size from a few nanometres to 10 μm in diameter. In addition to the ambient concentration, the pollution source and chemical composition may play roles in determining the biological toxicity and subsequent health effects. Nevertheless, studies from across the world have consistently shown that both short- and long-term exposures to PM are associated with a host of cardiovascular diseases, including myocardial ischaemia and infarctions, heart failure, arrhythmias, strokes and increased cardiovascular mortality. Evidence from cellular/toxicological experiments, controlled animal and human exposures and human panel studies have demonstrated several mechanisms by which particle exposure may both trigger acute events as well as prompt the chronic development of cardiovascular diseases. PM inhaled into the pulmonary tree may instigate remote cardiovascular health effects via three general pathways: instigation of systemic inflammation and/or oxidative stress, alterations in autonomic balance, and potentially by direct actions upon the vasculature of particle constituents capable of reaching the systemic circulation. In turn, these responses have been shown to trigger acute arterial vasoconstriction, endothelial dysfunction, arrhythmias and pro-coagulant/thrombotic actions. Finally, long-term exposure has been shown to enhance the chronic genesis of atherosclerosis. Although the risk to one individual at any single time point is small, given the prodigious number of people continuously exposed, PM air pollution imparts a tremendous burden to the global public health, ranking it as the 13th leading cause of morality (approx. 800000 annual deaths).
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Citations
Cites
An association between air pollution and mortality in six U.S. cities
Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., & Speizer, F. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312093292401 · Cited by 8,018
Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J. (2004) · Circulation · doi:10.1161/01.cir.0000108927.80044.7f · Cited by 2,592
Long-term exposure to air pollution and incidence of cardiovascular events in women
Miller, K. A., Siscovick, D. S., Sheppard, L., Shepherd, K., Sullivan, J. H., Anderson, G. L., & Kaufman, J. D. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa054409 · Cited by 1,854
Passage of inhaled particles into the blood circulation in humans
Nemmar, A., Hoet, P. H. M., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., & Nemery, B. (2002) · Circulation · doi:10.1161/hc0402.104118 · Cited by 1,719
Spatial analysis of air pollution and mortality in Los Angeles
Jerrett, M., Burnett, R. T., Ma, R., Pope, C. A., Krewski, D., Newbold, K. B., Thurston, G., Shi, Y., Finkelstein, N., Calle, E. E., et al. (2005) · Epidemiology · doi:10.1097/01.ede.0000181630.15826.7d · Cited by 985
La Rovere, M. T., Pinna, G. D., Maestri, R., Mortara, A., Capomolla, S., Febo, O., Ferrari, R., Franchini, M., Gnemmi, M., Opasich, C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000047275.25795.17 · Cited by 917
Increased plasma viscosity during an air pollution episode: a link to mortality?
Peters, A., Döring, A., Wichmann, H.-E., & Koenig, W. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01211-7 · Cited by 706
Inflammatory markers and particulate air pollution: characterizing the pathway to disease
Zeka, A., Sullivan, J. R., Vokonas, P. S., Sparrow, D., & Schwartz, J. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl132 · Cited by 205
Noninvasive detection of hydroxyl radical generation in lung by diesel exhaust particles
Han, J.-Y., Takeshita, K., & Utsumi, H. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00501-3 · Cited by 148
Cited by
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548
Self-citationRapid DNA methylation changes after exposure to traffic particles
Baccarelli, A., Wright, R. O., Bollati, V., Tarantini, L., Litonjua, A. A., Suh, H. H., Zanobetti, A., Sparrow, D., Vokonas, P. S., & Schwartz, J. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200807-1097oc · Cited by 653
Respiratory health effects of air pollution: Update on biomass smoke and traffic pollution
Laumbach, R. J., & Kipen, H. M. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.021 · Cited by 474
Santos, C. Y., Snyder, P. J., Wu, W., Zhang, M., Echeverria, A., & Alber, J. (2017) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.01.005 · Cited by 431
A Systematic Review of Global Desert Dust and Associated Human Health Effects
Zhang, X., Zhao, L., Tong, D., Wu, G., Dan, M., & Teng, B. (2016) · Atmosphere · doi:10.3390/atmos7120158 · Cited by 236
Metadata
- Authors
- Brook, R. D.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2008-08-12
- Volume
- 115
- Issue
- 6
- Pages
- 175-187
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W1995655017
- Cited by
- 657
- References
- 9
- FWCI
- 29.79
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
