The DOI matches its Crossref record; 198 of the 198 references it cites were found in a registry or an index.
Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools
Abstract
H2S (hydrogen sulfide) is a well known and pungent gas recently discovered to be synthesized enzymatically in mammalian and human tissues. In a relatively short period of time, H2S has attracted substantial interest as an endogenous gaseous mediator and potential target for pharmacological manipulation. Studies in animals and humans have shown H2S to be involved in diverse physiological and pathophysiological processes, such as learning and memory, neurodegeneration, regulation of inflammation and blood pressure, and metabolism. However, research is limited by the lack of specific analytical and pharmacological tools which has led to considerable controversy in the literature. Commonly used inhibitors of endogenous H2S synthesis have been well known for decades to interact with other metabolic pathways or even generate NO (nitric oxide). Similarly, commonly used H2S donors release H2S far too quickly to be physiologically relevant, but may have therapeutic applications. In the present review, we discuss the enzymatic synthesis of H2S and its emerging importance as a mediator in physiology and pathology. We also critically discuss the suitability of proposed ‘biomarkers’ of H2S synthesis and metabolism, and highlight the complexities of the currently used pharmacological H2S ‘donor’ molecules and ‘specific’ H2S synthesis inhibitors in their application to studying the role of H2S in human disease.
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Cites
H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
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Hydrogen Sulfide and Cell Signaling
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Hydrogen sulfide is an endogenous modulator of leukocyte‐mediated inflammation
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Self-citation
Cited by
Hydrogen sulfide chemical biology: pathophysiological roles and detection
Kolluru, G. K., Shen, X., Bir, S. C., & Kevil, C. G. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.002 · Cited by 480
Asimakopoulou, A., Panopoulos, P., Chasapis, C. T., Coletta, C., Zhou, Z., Cirino, G., Giannis, A., Szabo, C., Spyroulias, G. A., & Papapetropoulos, A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12171 · Cited by 393
Chemical foundations of hydrogen sulfide biology
Li, Q., & Lancaster, J. R. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.001 · Cited by 334
Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis
Wilcock, D. M., & Griffin, W. S. T. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-84 · Cited by 230
Analytical measurement of discrete hydrogen sulfide pools in biological specimens
Shen, X., Peter, E. A., Bir, S., Wang, R., & Kevil, C. G. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.007 · Cited by 214
Metadata
- Authors
- Whiteman, M., Le Trionnaire, S., Chopra, M., Fox, B., & Whatmore, J.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2011-08-09
- Volume
- 121
- Issue
- 11
- Pages
- 459-488
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W1971154550
- Cited by
- 310
- References
- 198
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Whiteman, M., Le Trionnaire, S., Chopra, M., Fox, B., & Whatmore, J. (2011). Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. Clinical Science. https://doi.org/10.1042/cs20110267
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