The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems
Open accessAbstract
Endothelial cells that form the inner layer of blood and lymphatic vessels are important regulators of vascular functions and centrally involved in the pathogenesis of vascular diseases. In addition to the vascular endothelial growth factor (VEGF) receptor pathway, the angiopoietin (Ang)–Tie system is a second endothelial cell specific ligand–receptor signalling system necessary for embryonic cardiovascular and lymphatic development. The Ang–Tie system also regulates postnatal angiogenesis, vessel remodelling, vascular permeability and inflammation to maintain vascular homoeostasis in adult physiology. This system is implicated in numerous diseases where the vasculature has an important contribution, such as cancer, sepsis, diabetes, atherosclerosis and ocular diseases. Furthermore, mutations in the TIE2 signalling pathway cause defects in vascular morphogenesis, resulting in venous malformations and primary congenital glaucoma. Here, we review recent advances in the understanding of the Ang–Tie signalling system, including cross-talk with the vascular endothelial protein tyrosine phosphatase (VE-PTP) and the integrin cell adhesion receptors, focusing on the Ang–Tie system in vascular development and pathogenesis of vascular diseases.
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Liu, Z.-L., Chen, H.-H., Zheng, L.-L., Sun, L.-P., & Shi, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01460-1 · Cited by 1,300
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Lopes-Coelho, F., Martins, F., Pereira, S. A., & Serpa, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073765 · Cited by 416
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Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway
Itatani, Y., Kawada, K., Yamamoto, T., & Sakai, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041232 · Cited by 346
UK Biobank Eye and Vision Consortium, Khawaja, A. P., NEIGHBORHOOD Consortium, Cooke Bailey, J. N., Wareham, N. J., Scott, R. A., Simcoe, M., Igo, R. P., Song, Y. E., Wojciechowski, R., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0126-8 · Cited by 346
Metadata
- Authors
- Eklund, L., Kangas, J., & Saharinen, P.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2016-12-09
- Volume
- 131
- Issue
- 1
- Pages
- 87-103
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W2559967567
- Cited by
- 202
- References
- 17
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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