Cited by 818Angiogenesis and VEGF in CancerLymphatic System and DiseasesVascular Tumors and Angiosarcomas

Increased Vascularization in Mice Overexpressing Angiopoietin-1

Suri, Chitra, McClain, Joyce, Thurston, Gavin, McDonald, Donald M., Zhou, Hao, Oldmixon, Eben H., Sato, Thomas N., Yancopoulos, George D.·1998·Science

Abstract

The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular endothelial cells. Targeted gene inactivation studies in mice have shown that VEGF is necessary for the early stages of vascular development and that angiopoietin-1 is required for the later stages of vascular remodeling. Here it is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more highly branched vessels. These results raise the possibility that angiopoietins can be used, alone or in combination with VEGF, to promote therapeutic angiogenesis.

Integrity signals

Registry

Crossref · 10.1126/science.282.5388.468

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Ang-2 is an antagonist for the Tie-2 receptor and is exclusively expressed in sites of vascular remodeling.

    “Ang-2, on the other hand, is an antagonist for the Tie-2 receptor and is exclu-sively expressed in sites of vascular remodeling (83,84,88)”

    From Adipose tissue remodeling and obesity (2011) · cites this paper as [88]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., & Yancopoulos, G. D.
Affiliations
University of California, San Francisco (US)
Corresponding author
Yancopoulos, George D.
Venue
Science
Published
1998-10-16
Volume
282
Issue
5388
Pages
468-471
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2051487747
Cited by
818
References
25
Citations by year
2026: 1 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 26 · 2014: 24 · 2013: 21 · 2012: 40
FWCI
15.61
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL059157, HL 24136, HL 59157, P01HL024136)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
Keywords
angiopoietin-1, transgenic overexpression, vascularization, skin vasculature, vascular branching, vascular remodeling, vascular endothelial growth factor, therapeutic angiogenesis, endothelial cells
MeSH terms
Animals, Capillaries, Endothelium, Vascular, Lymphokines, Membrane Glycoproteins, Mice, Transgenic, Skin, Venules, Keratinocytes, Gene Expression, Endothelial Growth Factors, Neovascularization, Physiologic, Transgenes, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Angiopoietin-1, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review