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Cited by 55Cellular transport and secretionCholesterol and Lipid MetabolismCaveolin-1 and cellular processes

The emerging role of sorting nexins in cardiovascular diseases

Open access
Yang, Jian, Villar, Van Anthony M., Rozyyev, Selim, Jose, Pedro A., Zeng, Chunyu·2019·Clinical Science
DOI 10.1042/cs20190034PMC PMC6418407
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Abstract

The sorting nexin (SNX) family consists of a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play pivotal roles in the regulation of protein trafficking. This includes the entire endocytic pathway, such as endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX pathway are involved in several forms of cardiovascular disease (CVD). Moreover, SNX gene variants are associated with CVDs. In this review, we discuss the current knowledge on SNX-mediated regulatory mechanisms and their roles in the pathogenesis and treatment of CVDs.

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  • Impairment of SNX pathway is responsible for development of various forms of cardiovascular disease.

    “Impairment of SNX pathway is responsible for the development of various forms of cardiovascular disease (CVD) [126].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [126]

    The Conclusions and perspectives table reports that SNX1 loss raises blood pressure, while the section on other cardiovascular diseases describes a mechanism by which SNX13 loss promotes heart failure. But the coronary artery disease section explicitly says direct evidence of a causal relationship is lacking. The claim overstates the evidence by treating SNX impairment as an established cause of various forms of CVD. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • Several endocytic proteins including SNX, epsins, and Dab2 play an indispensable role in cardiovascular diseases.

    “Several endocytic proteins including sorting nexin (SNX), epsins, and disabled homolog 2 (Dab2) play an indispensable role in cardiovascular diseases [126].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [126]

    The Abstract and Conclusions and perspectives describe sorting nexins as endocytic-trafficking proteins with roles in cardiovascular disease. The supplied passages and searches for “epsins” and “Dab2” provide no support for attributing those proteins’ cardiovascular roles to this source. Page numbers were not available in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • SNX19 is associated with coronary artery disease.

    “Further, studies have also established the association of other SNX, such as SNX19, with coronary artery disease.”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [126]

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Cited by

Sorted by citations

Authors
Yang, J., Villar, V. A. M., Rozyyev, S., Jose, P. A., & Zeng, C.
Affiliations
  • Army Medical University (CN)
  • George Washington University (US)
  • Division of Renal Diseases and Hypertension, Department of Medicine, and Department of Pharmacology/Physiology, The George Washington University School of Medicine and Health Sciences, Washington, DC 20052, U.S.A.
Corresponding author
  • Yang, Jian
  • Zeng, Chunyu
ORCID
Venue
Clinical Science
Publisher
Portland Press Ltd.
Published
2019-03
Volume
133
Issue
5
Pages
723-737
ISSN
  • 0143-5221 (ISSN-L)
  • 1470-8736
DOI
10.1042/cs20190034
PMC
PMC6418407
OpenAlex
W2921179399
Cited by
55
References
4
Citations by year
2026: 3 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 7 · 2021: 11 · 2020: 10
FWCI
0.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Science (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81770425, 2018YFC1312700, 81570379, 81721001)
  • National Institutes of Health (and 5P01HL074940)
  • National Heart, Lung, and Blood Institute (P01HL074940, R01HL092196)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK039308)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords
sorting nexins, phosphoinositide-binding proteins, protein trafficking, endocytosis, endosomal sorting, endosomal signaling, cardiovascular disease, pathogenesis, cardiovascular disease treatment
MeSH terms
Animals, Cardiovascular Diseases, Cardiovascular System, Endocytosis, Humans, Prognosis, Endosomes, Signal Transduction, Protein Transport, Sorting Nexins

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