The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Regulation of selective autophagy: the p62/SQSTM1 paradigm
Abstract
In selective autophagy, cytoplasmic components are selected and tagged before being sequestered into an autophagosome by means of selective autophagy receptors such as p62/SQSTM1. In this review, we discuss how selective autophagy is regulated. An important level of regulation is the selection of proteins or organelles for degradation. Components selected for degradation are tagged, often with ubiquitin, to facilitate recognition by autophagy receptors. Another level of regulation is represented by the autophagy receptors themselves. For p62, its ability to co-aggregate with ubiquitinated substrates is strongly induced by post-translational modifications (PTMs). The transcription of p62 is also markedly increased during conditions in which selective autophagy substrates accumulate. For other autophagy receptors, the LC3-interacting region (LIR) motif is regulated by PTMs, inhibiting or stimulating the interaction with ATG8 family proteins. ATG8 proteins are also regulated by PTMs. Regulation of the capacity of the core autophagy machinery also affects selective autophagy. Importantly, autophagy receptors can induce local recruitment and activation of ULK1/2 and PI3KC3 complexes at the site of cargo sequestration.
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Self-citationThe Role of Atg Proteins in Autophagosome Formation
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
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Self-citationNix is a selective autophagy receptor for mitochondrial clearance
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The mammalian ULK1 complex and autophagy initiation
Zachari, M., & Ganley, I. G. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170021 · Cited by 789
Roles of Autophagy in Oxidative Stress
Yun, H. R., Jo, Y. H., Kim, J., Shin, Y., Kim, S. S., & Choi, T. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093289 · Cited by 396
Bile acids and their receptors in metabolic disorders
Fiorucci, S., Distrutti, E., Carino, A., Zampella, A., & Biagioli, M. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101094 · Cited by 258
Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189
“(TB) motif, a KEAP1-interacting region (KIR), and a ubiquitin-associated (UBA) domain [85,86].”
BackgroundTargeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery
Pei, J., Wang, G., Feng, L., Zhang, J., Jiang, T., Sun, Q., & Ouyang, L. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01689 · Cited by 124
Metadata
- Authors
- Lamark, T., Svenning, S., & Johansen, T.
- Venue
- Essays in Biochemistry
- Publisher
- Portland Press Ltd.
- Published
- 2017-12-12
- Volume
- 61
- Issue
- 6
- Pages
- 609-624
- ISSN
- 0071-1365 (ISSN-L)
- 1744-1358
- OpenAlex
- W2773258360
- Cited by
- 743
- References
- 25
- FWCI
- 27.64
- Type
- journal article
- Language
- en
- Open access
- closed
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