Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery

Tissue-based map of the human proteome

Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286 · see citing works

Mechanisms of endocytosis

Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075 · see citing works

Mechanism and medical implications of mammalian autophagy

Dikic, I., & Elazar, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0003-4 · Cited by 2,771 · see citing works

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

Sakamoto, K. M., Kim, K. B., Kumagai, A., Mercurio, F., Crews, C. M., & Deshaies, R. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141230798 · Cited by 2,609 · see citing works

Eaten alive: a history of macroautophagy

Yang, Z., & Klionsky, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-814 · Cited by 2,096 · see citing works

The F-box protein TIR1 is an auxin receptor

Dharmasiri, N., Dharmasiri, S., & Estelle, M. (2005) · Nature · doi:10.1038/nature03543 · Cited by 2,083 · see citing works

Phthalimide conjugation as a strategy for in vivo target protein degradation

Winter, G. E., Buckley, D. L., Paulk, J., Roberts, J. M., Souza, A., Dhe-Paganon, S., & Bradner, J. E. (2015) · Science · doi:10.1126/science.aab1433 · Cited by 1,760 · see citing works

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

Säftig, P., & Klumperman, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2745 · Cited by 1,702 · see citing works

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

Settembre, C., Fraldi, A., Medina, D. L., & Ballabio, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3565 · Cited by 1,689 · see citing works

Pathways of clathrin-independent endocytosis

Mayor, S., & Pagano, R. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2216 · Cited by 1,556 · see citing works

Induced protein degradation: an emerging drug discovery paradigm

Lai, A. C., & Crews, C. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.211 · Cited by 1,486 · see citing works

The current state and future directions of RNAi-based therapeutics

Setten, R. L., Rossi, J. J., & Han, S.-P. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0017-4 · Cited by 1,443 · see citing works

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.657 · Cited by 1,361 · see citing works

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.

Pandey, U. B., Nie, Z., Batlevi, Y., McCray, B. A., Ritson, G. P., Nedelsky, N. B., Schwartz, S. L., DiProspero, N. A., Knight, M. A., Schuldiner, O., et al. (2007) · Nature · doi:10.1038/nature05853 · Cited by 1,234 · see citing works

A Role for Ubiquitin in Selective Autophagy

Kirkin, V., McEwan, D. G., Novak, I., & Đikić, I. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.026 · Cited by 1,227 · see citing works

Cargo recognition and trafficking in selective autophagy

Stolz, A., Ernst, A., & Dikic, I. (2014) · Nature Cell Biology · doi:10.1038/ncb2979 · Cited by 1,207 · see citing works

Lysosome-targeting chimaeras for degradation of extracellular proteins

Banik, S. M., Pedram, K., Wisnovsky, S., Ahn, G., Riley, N. M., & Bertozzi, C. R. (2020) · Nature · doi:10.1038/s41586-020-2545-9 · Cited by 1,199 · see citing works

The dTAG system for immediate and target-specific protein degradation

Nabet, B., Roberts, J. M., Buckley, D. L., Paulk, J., Dastjerdi, S., Yang, A., Leggett, A. L., Erb, M. A., Lawlor, M. A., Souza, A., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0021-8 · Cited by 1,118 · see citing works

Autophagy Defends Cells Against Invading Group A Streptococcus

Nakagawa, I., Amano, A., Mizushima, N., Yamamoto, A., Yamaguchi, H., Kamimoto, T., Nara, A., Funao, J., Nakata, M., Tsuda, K., et al. (2004) · Science · doi:10.1126/science.1103966 · Cited by 1,091 · see citing works

Mannose 6-phosphate receptors: new twists in the tale

Ghosh, P., Dahms, N. M., & Kornfeld, S. A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1050 · Cited by 1,086 · see citing works

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

Burslem, G. M., & Crews, C. M. (2020) · Cell · doi:10.1016/j.cell.2019.11.031 · Cited by 1,079 · see citing works

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

Cuervo, A. M., & Dice, J. F. (1996) · Science · doi:10.1126/science.273.5274.501 · Cited by 979 · see citing works

Targeted protein degradation: expanding the toolbox

Schapira, M., Calabrese, M. F., Bullock, A. N., & Crews, C. M. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0047-y · Cited by 960 · see citing works

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

Rupprecht, R., Papadopoulos, V., Rammes, G., Baghai, T. C., Fan, J., Akula, N., Groyer, G., Adams, D., & Schumacher, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3295 · Cited by 930 · see citing works

Sorting of lysosomal proteins

Braulke, T., & Bonifacino, J. S. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.10.016 · Cited by 873 · see citing works

The mannose 6-phosphate receptor and the biogenesis of lysosomes

Griffiths, G. W., Hoflack, B., Simons, K., Mellman, I., & Kornfeld, S. A. (1988) · Cell · doi:10.1016/s0092-8674(88)80026-6 · Cited by 856 · see citing works

Chaperone-mediated autophagy: a unique way to enter the lysosome world

Kaushik, S., & Cuervo, A. M. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.05.006 · Cited by 850 · see citing works

Lysosome biology in autophagy

Yim, W. W., & Mizushima, N. (2020) · Cell Discovery · doi:10.1038/s41421-020-0141-7 · Cited by 800 · see citing works

Lysosomal membrane permeabilization and cell death

Wang, F., Gómez‐Sintes, R., & Boya, P. (2018) · Traffic · doi:10.1111/tra.12613 · Cited by 781 · see citing works

Autophagy and human diseases

Jiang, P., & Mizushima, N. (2013) · Cell Research · doi:10.1038/cr.2013.161 · Cited by 767 · see citing works

Lysosomes as a therapeutic target

Bonam, S. R., Wang, F., & Muller, S. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0036-1 · Cited by 764 · see citing works

Regulation of selective autophagy: the p62/SQSTM1 paradigm

Lamark, T., Svenning, S., & Johansen, T. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170035 · Cited by 742 · see citing works

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

Ding, W.-X., Ni, H.-M., Gao, W., Yoshimori, T., Stolz, D. B., Ron, D., & Yin, X.-M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070188 · Cited by 708 · see citing works

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

Takahashi, D., Moriyama, J., Nakamura, T., Miki, E., Takahashi, E., Sato, A., Akaike, T., Itto-Nakama, K., & Arimoto, H. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.009 · Cited by 675 · see citing works

The Lysosome as a Regulatory Hub

Perera, R. M., & Zoncu, R. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125125 · Cited by 664 · see citing works

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

Liu, H., Zhang, H., Wu, X., Ma, D., Wu, J., Wang, L., Jiang, Y., Fei, Y., Zhu, C., Tan, R., et al. (2018) · Nature · doi:10.1038/s41586-018-0629-6 · Cited by 651 · see citing works

Selective autophagy: ubiquitin-mediated recognition and beyond

Kraft, C., Peter, M., & Hofmann, K. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-836 · Cited by 639 · see citing works

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

Sin, N., Meng, L., Wang, M. Q. W., Wen, J., Bornmann, W. G., & Crews, C. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6099 · Cited by 634 · see citing works

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

Boland, B., Yu, W. H., Corti, O., Mollereau, B., Henriques, A., Bézard, E., Pastores, G., Rubinsztein, D. C., Nixon, R. A., Duchen, M. R., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.109 · Cited by 552 · see citing works

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

Li, Z., Wang, C., Wang, Z., Zhu, C., Li, J., Sha, T., Ma, L., Gao, C., Yang, Y., Sun, Y., et al. (2019) · Nature · doi:10.1038/s41586-019-1722-1 · Cited by 551 · see citing works

Ubiquitin: Same Molecule, Different Degradation Pathways

Clague, M. J., & Urbé, S. (2010) · Cell · doi:10.1016/j.cell.2010.11.012 · Cited by 535 · see citing works

A Method for the Acute and Rapid Degradation of Endogenous Proteins

Clift, D., McEwan, W. A., Labzin, L. I., Konieczny, V., Mogessie, B., James, L. C., & Schuh, M. (2017) · Cell · doi:10.1016/j.cell.2017.10.033 · Cited by 531 · see citing works

Autophagy: Basic Principles and Relevance to Disease

Kundu, M., & Thompson, C. B. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.091842 · Cited by 523 · see citing works

The asialoglycoprotein receptor: a model for endocytic transport receptors

Spiess, M. (1990) · Biochemistry · doi:10.1021/bi00495a001 · Cited by 488 · see citing works

A molecular chaperone complex at the lysosomal membrane is required for protein translocation

Agarraberes, F. A., & Dice, J. F. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.13.2491 · Cited by 404 · see citing works

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy

Li, J. Y., Perry, S. R., Muniz-Medina, V. M., Wang, X., Wetzel, L. K., Rebelatto, M. C., Hinrichs, M. J., Bezabeh, B. Z., Fleming, R. L., Dimasi, N., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2015.12.008 · Cited by 400 · see citing works

Transferrin receptor 1 in cancer: a new sight for cancer therapy.

Shen, Y., Li, X., Dong, D., Zhang, B., Xue, Y., & Shang, P. (2018) · Europe PMC (PubMed Central) · Cited by 357 · see citing works

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

Wang, H., Yao, H., Li, C., Shi, H., Lan, J., Li, Z., Zhang, Y., Liang, L., Fang, J., & Xu, J. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0161-x · Cited by 327 · see citing works

Mutant NPM1 Maintains the Leukemic State through HOX Expression

Brunetti, L., Gundry, M. C., Sorcini, D., Guzman, A. G., Huang, Y., Ramabadran, R., Gionfriddo, I., Mezzasoma, F., Milano, F., Nabet, B., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.08.005 · Cited by 314 · see citing works

Mitochondria–Lysosome Crosstalk: From Physiology to Neurodegeneration

Deus, C. M., Yambire, K. F., Oliveira, P. J., & Raimundo, N. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.10.009 · Cited by 291 · see citing works

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

Bauer, P. O., Goswami, A., Wong, H. K., Okuno, M., Kurosawa, M., Yamada, M., Miyazaki, H., Matsumoto, G., Kino, Y., Nagai, Y., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1608 · Cited by 280 · see citing works

Protein S-guanylation by the biological signal 8-nitroguanosine 3′,5′-cyclic monophosphate

Sawa, T., Zaki, M. H., Okamoto, T., Akuta, T., Tokutomi, Y., Kim‐Mitsuyama, S., Ihara, H., Kobayashi, A., Yamamoto, M. P., Fujii, S., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.33 · Cited by 273 · see citing works

Targeting autophagy-related protein kinases for potential therapeutic purpose

Xiang, H., Zhang, J., Lin, C., Zhang, L., Liu, B., & Ouyang, L. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.10.003 · Cited by 254 · see citing works

Endolysosomal proteolysis and its regulation

Pillay, C. S., Elliott, E., & Dennison, C. (2002) · Biochemical Journal · doi:10.1042/bj3630417 · Cited by 247 · see citing works

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

Ohoka, N., Okuhira, K., Ito, M., Nagai, K., Shibata, N., Hattori, T., Ujikawa, O., Shimokawa, K., Sano, O., Koyama, R., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.768853 · Cited by 240 · see citing works

Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

Zimmermann, T. S., Karsten, V., Chan, A., Chiesa, J., Boyce, M. J., Bettencourt, B. R., Hutabarat, R. M., Nochur, S. V., Vaishnaw, A. K., & Gollob, J. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.10.019 · Cited by 216 · see citing works

Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation

Fan, X., Wu, J., Lu, J., Wang, J., & Wang, Y. T. (2014) · Nature Neuroscience · doi:10.1038/nn.3637 · Cited by 213 · see citing works

Critical Functions of the Lysosome in Cancer Biology

Davidson, S. M., & Heiden, M. G. V. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103101 · Cited by 209 · see citing works

Emerging New Concepts of Degrader Technologies

Ding, Y., Fei, Y., & Lu, B. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.04.005 · Cited by 204 · see citing works

Endocytosis and Autophagy: Exploitation or Cooperation?

Tooze, S. A., Abada, A., & Elazar, Z. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018358 · Cited by 202 · see citing works

The ubiquitin-proteasome system and autophagy: Coordinated and independent activities

Cohen‐Kaplan, V., Livneh, I., Avni, N., Cohen-Rosenzweig, C., & Ciechanover, A. J. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.019 · Cited by 196 · see citing works

Inhibition of Polyglutamine Protein Aggregation and Cell Death by Novel Peptides Identified by Phage Display Screening

Nagai, Y., Tucker, T. J., Ren, H., Kenan, D. J., Henderson, B. S., Keene, J. D., Strittmatter, W. J., & Burke, J. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10437 · Cited by 186 · see citing works

The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acidα2,6GalNAc

Park, E. I., Mi, Y., Unverzagt, C., Gabius, H., & Baenziger, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508537102 · Cited by 170 · see citing works

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

Yamazaki, Y., Painter, M. M., Bu, G., & Kanekiyo, T. (2016) · CNS Drugs · doi:10.1007/s40263-016-0361-4 · Cited by 166 · see citing works

MBSJ MCC Young Scientist Award 2009 REVIEW: Selective autophagy regulates various cellular functions

Komatsu, M., & Ichimura, Y. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01433.x · Cited by 159 · see citing works

Elucidation and Structural Modeling of CD71 as a Molecular Target for Cell-Specific Aptamer Binding

Wu, X., Liu, H., Han, D., Peng, B., Zhang, H., Zhang, L., Li, J., Liu, J., Cui, C., Fang, S., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b03720 · Cited by 158 · see citing works

Pumilio1 Haploinsufficiency Leads to SCA1-like Neurodegeneration by Increasing Wild-Type Ataxin1 Levels

Gennarino, V. A., Singh, R. K., White, J. J., Maio, A. D., Han, K., Kim, J., Jafar‐Nejad, P., di Ronza, A., Kang, H., Sayegh, L. S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.012 · Cited by 149 · see citing works

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

Spangler, J. B., Neil, J. R., Abramovitch, S., Yarden, Y., White, F. M., Lauffenburger, D. A., & Wittrup, K. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913476107 · Cited by 147 · see citing works

Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila

Nagai, Y. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg144 · Cited by 145 · see citing works

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates

Bonam, S. R., Ruff, M., & Muller, S. (2019) · Cells · doi:10.3390/cells8080849 · Cited by 143 · see citing works

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

John, J. S. (2007) · Frontiers in bioscience · doi:10.2741/2714 · Cited by 134 · see citing works

Single-step detection of mutant huntingtin in animal and human tissues: A bioassay for Huntington’s disease

Weiss, A., Abramowski, D., Bibel, M., Bodner, R. A., Chopra, V., DiFiglia, M., Fox, J. H., Kegel, K. B., Klein, C., Grueninger, S., et al. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2009.08.001 · Cited by 126 · see citing works

Regulated exocytosis: new organelles for non-secretory purposes

Chieregatti, E., & Meldolesi, J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1572 · Cited by 125 · see citing works

Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins — A review

Yang, C., Qin, C., Bai, L., & Wang, S. (2019) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2019.04.001 · Cited by 125 · see citing works

Autophagy: links with the proteasome

Lamark, T., & Johansen, T. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.002 · Cited by 124 · see citing works

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

Pan, B., Li, J., Parajuli, N., Tian, Z., Wu, P., Lewno, M. T., Zou, J., Wang, W., Bedford, L., Mayer, R. J., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316007 · Cited by 122 · see citing works

A shortcut to the lysosome: The mannose-6-phosphate-independent pathway

Coutinho, M. F., Prata, M. J., & Alves, S. (2012) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2012.07.012 · Cited by 120 · see citing works

Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria

Ito, C., Saito, Y., Nozawa, T., Fujii, S., Sawa, T., Inoue, H., Matsunaga, T., Khan, S., Akashi, S., Hashimoto, R., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.024 · Cited by 115 · see citing works

Proteasome functional insufficiency activates the calcineurin–NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

Tang, M., Li, J., Huang, W., et al. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq217 · Cited by 114 · see citing works

CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis

di Ronza, A., Bajaj, L., Sharma, J., Sanagasetti, D., Lotfi, P., Adamski, C. J., Collette, J. R., Palmieri, M., Amawi, A., Popp, L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0228-7 · Cited by 112 · see citing works

Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications

Guruceaga, X., Perez‐Cuesta, U., Abad, A., González, O., Alonso, R. M., Hernando, F. L., Ramirez‐Garcia, A., & Rementerı́a, A. (2019) · Toxins · doi:10.3390/toxins12010007 · Cited by 105 · see citing works

Nanoformulation of PROteolysis Targeting Chimera TArgeting ‘Undruggable’ C-Myc for The Treatment of Pancreatic Cancer

Saraswat, A. L., Patki, M., Fu, Y., Barot, S., Dukhande, V. V., & Patel, K. R. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0156 · Cited by 105 · see citing works

Cullin E3 Ligases and Their Rewiring by Viral Factors

Mahon, C., Krogan, N., Craik, C., & Pick, E. (2014) · Biomolecules · doi:10.3390/biom4040897 · Cited by 101 · see citing works

Targeting selective autophagy by AUTAC degraders

Takahashi, D., & Arimoto, H. (2020) · Autophagy · doi:10.1080/15548627.2020.1718362 · Cited by 96 · see citing works

PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders

Tomoshige, S., & Ishikawa, M. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202004746 · Cited by 84 · see citing works

TR-FRET-Based Duplex Immunoassay Reveals an Inverse Correlation of Soluble and Aggregated Mutant huntingtin in Huntington's Disease

Baldo, B., Paganetti, P., Grueninger, S., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.12.020 · Cited by 81 · see citing works

Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy

Landry, J. P., Zhu, X. D., & Gregg, J. (2004) · Optics Letters · doi:10.1364/ol.29.000581 · Cited by 74 · see citing works

TRAF6 coordinates the activation of autophagy and ubiquitin-proteasome systems in atrophying skeletal muscle

Paul, P. K., & Kumar, A. (2011) · Autophagy · doi:10.4161/auto.7.5.15102 · Cited by 72 · see citing works

Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical reactions in a microarray format

Zhu, X. D., Landry, J. P., Sun, Y.-S., Gregg, J. P., Lam, K. S., & Guo, X. (2007) · Applied Optics · doi:10.1364/ao.46.001890 · Cited by 70 · see citing works

Targeting BET bromodomain proteins in cancer: The example of lymphomas

Spriano, F., Stathis, A., & Bertoni, F. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107631 · Cited by 69 · see citing works

FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6

Galfrè, E., Pitt, S. J., Venturi, E., Sitsapesan, M., Zaccai, N. R., Tsaneva-Atanasova, K. T., O'Neill, S. C., & Sitsapesan, R. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031956 · Cited by 68 · see citing works

Translocator protein (18 kDa), a potential molecular imaging biomarker for non-invasively distinguishing non-alcoholic fatty liver disease

Xie, L., Yui, J., Hatori, A., Yamasaki, T., Kumata, K., Wakizaka, H., Yoshida, Y., Fujinaga, M., Kawamura, K., & Zhang, M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.002 · Cited by 67 · see citing works

Emerging drug development technologies targeting ubiquitination for cancer therapeutics

Veggiani, G., Gerpe, M. C. R., Sidhu, S. S., & Zhang, W. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.003 · Cited by 64 · see citing works

The sorting and trafficking of lysosomal proteins.

Ni, X., Canuel, M., & Morales, C. R. (2006) · PubMed · doi:10.14670/hh-21.899 · Cited by 63 · see citing works

Autophagy Regulates Homeostasis of Pluripotency-Associated Proteins in hESCs

Cho, Y.-H., Han, K.-M., Kim, D., Lee, J., Lee, S., Choi, K., Kim, J., & Han, Y. (2013) · Stem Cells · doi:10.1002/stem.1589 · Cited by 60 · see citing works

Autophagy: A new concept in autoimmunity regulation and a novel therapeutic option

Bonam, S. R., Wang, F., & Muller, S. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.08.009 · Cited by 55 · see citing works

Characterization of Receptor Binding Profiles of Influenza A Viruses Using An Ellipsometry-Based Label-Free Glycan Microarray Assay Platform

Fei, Y., Sun, Y.-S., Li, Y., et al. (2015) · Biomolecules · doi:10.3390/biom5031480 · Cited by 54 · see citing works

Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation

Tucker, L. A., Zhang, Q., Sheppard, G. S., Lou, P., Jiang, F., McKeegan, E. M., Lesniewski, R., Davidsen, S. K., Bell, R. L., & Wang, J. (2008) · Oncogene · doi:10.1038/onc.2008.14 · Cited by 51 · see citing works

Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types

Wang, G., Zhao, Y., Liu, Y., Sun, D., Zhen, Y., Liu, J., Fu, L., Zhang, L., & Ouyang, L. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01896 · Cited by 49 · see citing works

Molecular Mechanisms of Lysosome and Nucleus Communication

Zhao, Q., Gao, S. M., & Wang, M. C. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.06.004 · Cited by 48 · see citing works

A Bifunctional Molecule That Displays Context-Dependent Cellular Activity

Braun, P. D., Barglow, K. T., Lin, Y., et al. (2003) · Journal of the American Chemical Society · doi:10.1021/ja035176q · Cited by 46 · see citing works

BRD4 regulates key transcription factors that drive epithelial–mesenchymal transition in castration-resistant prostate cancer

Shafran, J. S., Jafari, N., Casey, A. N., et al. (2020) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-020-0246-y · Cited by 43 · see citing works

The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke

Zhou, Y., Wang, J., Deng, M., Chi, B., Wei, N., Chen, J., Liu, D., Yin, X., Lu, Y., & Zhu, L. (2019) · Aging and Disease · doi:10.14336/ad.2018.1225 · Cited by 38 · see citing works

Evolution of the 12 kDa FK506‐binding protein gene

Somarelli, J. A., & Herrera, R. J. (2007) · Biology of the Cell · doi:10.1042/bc20060125 · Cited by 33 · see citing works

Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer

Heinrich, T., Seenisamy, J., Becker, F., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01070 · Cited by 33 · see citing works

Endothelial cells are intrinsically defective in xenophagy of Streptococcus pyogenes

Lu, S.-L., Kawabata, T., Cheng, Y., Omori, H., Hamasaki, M., Kusaba, T., Iwamoto, R., Arimoto, H., Noda, T., Lin, Y.-S., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006444 · Cited by 31 · see citing works

Ubiquitination at the interface of tumor viruses and DNA damage responses

Dybas, J. M., Herrmann, C., & Weitzman, M. D. (2018) · Current Opinion in Virology · doi:10.1016/j.coviro.2018.08.017 · Cited by 31 · see citing works

Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors

Heinrich, T., Seenisamy, J., Blume, B., Bomke, J., Calderini, M., Eckert, U., Friese‐Hamim, M., Kohl, R., Lehmann, M., Leuthner, B., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00041 · Cited by 30 · see citing works

Discovering Small Molecule Ligands of Vascular Endothelial Growth Factor That Block VEGF–KDR Binding Using Label-Free Microarray-Based Assays

Landry, J. P., Fei, Y., Zhu, X. D., Ke, Y., Yu, G., & Lee, P. (2013) · Assay and Drug Development Technologies · doi:10.1089/adt.2012.485 · Cited by 27 · see citing works

Targeted protein degradation in antibacterial drug discovery?

Gopal, P., & Dick, T. (2019) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2019.11.005 · Cited by 24 · see citing works

Locus-Specific Knock-In of a Degradable Tag for Target Validation Studies

Brand, M., & Winter, G. E. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9145-7_7 · Cited by 23 · see citing works

Role of LIMP-2 in the intracellular trafficking of β-glucosidase in different human cellular models

Malini, E., Zampieri, S., Deganuto, M., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-271148 · Cited by 22 · see citing works

The Long and the Short of BRD4: Two Tales in Breast Cancer

Zhang, S., & Roeder, R. G. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.033 · Cited by 16 · see citing works

New class of molecule targets proteins outside cells for degradation

Whitworth, C., & Ciulli, A. (2020) · Nature · doi:10.1038/d41586-020-02211-w · Cited by 16 · see citing works

Lysosome Targeting Chimeras (LYTACs) That Engage a Liver-Specific Asialoglycoprotein Receptor for Targeted Protein DegradationPreprint

Ahn, G., Banik, S. M., Miller, C. L., et al. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12736778.v1 · Cited by 13 · see citing works

Fast Focal Point Correction in Prism-Coupled Total Internal Reflection Scanning Imager Using an Electronically Tunable Lens

Zhu, C., Ge, B., Chen, R., et al. (2018) · Sensors · doi:10.3390/s18020524 · Cited by 12 · see citing works

Strategy to selectively remove mutant proteins could combat neurodegeneration

Zoghbi, H. Y. (2019) · Nature · doi:10.1038/d41586-019-03243-7 · Cited by 2 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Tumor cell plasticity in targeted therapy-induced resistance: Mechanisms and new strategies

Shi, Z.-D., Pang, K., Wu, Z.-X., Dong, Y., Hao, L., Qin, J.-X., Wang, W., Chen, Z.-S., & Han, C.-H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01383-x · Cited by 256 · see citing works

Application of Novel Degraders Employing Autophagy for Expediting Medicinal Research

Li, X., Liu, Q., Xie, X., Peng, C., Pang, Q., Liu, B., & Han, B. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01712 · Cited by 46 · see citing works

Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes

Ovaa, H., Overkleeft, H. S., Kessler, B. M., & Ploegh, H. L. (2005) · doi:10.1002/9783527620210.ch3 · Cited by 2 · see citing works

Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes

Ovaa, H., Overkleeft, H. S., Kessler, B. M., & Ploegh, H. L. (2007) · doi:10.1002/9783527619320.ch3a

Regulation of proteolysis

Attaix, D., Combaret, L., Pouch-Pélissier, M.-N., & Taillandier, D. (2001) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200101000-00009 · Cited by 74 · see citing works

Proteasomes: protein degradation machines of the cell

Peters, J. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90115-5 · Cited by 311 · see citing works

Regulation of Protein Degradation by Proteasomes in Cancer

Jang, H. H. (2018) · Journal of Cancer Prevention · doi:10.15430/jcp.2018.23.4.153 · Cited by 101 · see citing works