The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The role of protein phosphorylation in human health and disease.: Delivered on June 30th 2001 at the FEBS Meeting in Lisbon
Open accessAbstract
The reversible phosphorylation of proteins regulates almost all aspects of cell life, while abnormal phosphorylation is a cause or consequence of many diseases. Mutations in particular protein kinases and phosphatases gives rise to a number of disorders and many naturally occurring toxins and pathogens exert their effects by altering the phosphorylation states of intracellular proteins. In this lecture, I present an overview of the progress that is being made in developing specific inhibitors of protein kinases for the treatment of cancer and chronic inflammatory diseases and describe how recent advances in our understanding of the specificity and regulation of one particular protein kinase (GSK3) may facilitate the development of drugs to treat diabetes that would not have the potential to be oncogenic. I also discuss the exploitation of specific protein kinase inhibitors for the study of cell signalling and make recommendations for their effective use in cell‐based assays.
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Citations
Cites
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Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Self-citationCalcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
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Cited by
Marchetti, A., Martella, C., Felicioni, L., Barassi, F., Salvatore, S., Chella, A., Camplese, P. P., Iarussi, T., Mucilli, F., Mezzetti, A., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.08.043 · Cited by 788
The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601
Ward, P., Equinet, L., Packer, J., & Doerig, C. (2004) · BMC Genomics · doi:10.1186/1471-2164-5-79 · Cited by 507
The ErbB/HER receptor protein-tyrosine kinases and cancer
Roskoski, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.150 · Cited by 395
Ten things you should know about protein kinases: IUPHAR R eview 14
Fabbro, D., Cowan‐Jacob, S. W., & Moebitz, H. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13096 · Cited by 347
Metadata
- Authors
- Cohen, P.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 2001-10
- Volume
- 268
- Issue
- 19
- Pages
- 5001-5010
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W1538925875
- Cited by
- 634
- References
- 3
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cohen, P. (2001). The role of protein phosphorylation in human health and disease.: Delivered on June 30th 2001 at the FEBS Meeting in Lisbon. European Journal of Biochemistry. https://doi.org/10.1046/j.0014-2956.2001.02473.x
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