The DOI matches its Crossref record.
Stereotactic co‐registration of magnetic resonance imaging and histopathology in post‐mortem multiple sclerosis brain
Abstract
A number of groups have examined the pathological substrate of signal changes on magnetic resonance imaging (MRI) in post-mortem (PM) brain of patients with multiple sclerosis (MS). Such studies will benefit from using a standardized method to reliably co-register regions of interest on MRI and tissue specimens. We investigated the usefulness of a stereotactic navigation system for this purpose. We also addressed the sensitivity of different standard MRI sequences with regard to lesion conspicuity in PM MS brain. Post-mortem brains of eight patients with MS were studied. Formalin-fixed coronal slices were placed in the head frame of a stereotactic system. Proton density-, T2-weighted and fast fluid-attenuated inversion recovery (FLAIR) scans were obtained and visually matched with scans that had been previously obtained on the same, but fresh, specimens. Guided by the stereotactic target points, the dissection of the fixed specimens was performed. After processing the blocks for embedding in paraffin, sections were stained with haematoxylin-eosin and Luxol fast blue. T2-weighted MRI of fixed brain revealed 24 areas suspected to be MS lesions, all of which were confirmed histologically. Three of these lesions were not visible on macroscopic inspection. There were 14 additional hyperintensities on T2-weighted or FLAIR MRI of the fresh specimens, five of which did not correlate to MS lesions histologically. Stereotactic navigation is a useful approach to co-register MRI and hist…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A stereotactic procedure was employed to optimize correspondence between ROIs defined on MRI and their pathological substrate in the specimens.
“In order to optimize correspondence between ROIs defined on MRI with their pathological substrate in the specimens a stereotactic procedure (StP) was employed (Schmierer et al., 2003).”
From Diffusion tensor imaging of post mortem multiple sclerosis brain (2007) · cites this paper as Schmierer et al., 2003
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 18
- 10.1002/ana.1053 · DOI
- 10.3109/02841859909175593 · DOI
- Boyko OB, 1994, Utility of postmortem magnetic resonance imaging in clinical neuropathology, Arch Pathol Lab Med, 118, 219
- 10.1002/ana.410420515 · DOI
- 10.1093/brain/124.8.1635 · DOI
- 10.1046/j.1365-2990.1999.00159.x · DOI
- 10.1177/135245850200800109 · DOI
- 10.1227/00006123-199410000-00015 · DOI
- 10.1093/brain/121.1.3 · DOI
- 10.1212/WNL.55.10.1506 · DOI · Paper page
- 10.1016/0165-0270(88)90126-4 · DOI
- 10.1016/0022-510X(87)90184-5 · DOI
- 10.1093/brain/114.2.1013 · DOI
- 10.1177/197140099200500413 · DOI
- Schmierer K, 2002, Quantitative assessment of lesion pathology in post‐mortem MS brain: a correlative MRI/histology study, Mult Scler, 8, S47
- Truyen L, 1996, Accumulation of hypointense lesions (‘black holes’) on T1 spin‐echo MRI correlates with disease progression in multiple sclerosis, Neurology, 47, 1469, 10.1212/WNL.47.6.1469 · DOI
- 10.1002/1531-8249(199911)46:5<747::AID-ANA10>3.0.CO;2-4 · DOI
- Van Walderveen MA, 1998, Histopathologic correlate of hypointense lesions on T1‐weighted spin‐echo MRI in multiple sclerosis, Neurology, 50, 1282, 10.1212/WNL.50.5.1282 · DOI · Paper page
Cited by
Sorted by citations
Diffusion tensor imaging of post mortem multiple sclerosis brain
Schmierer, K., Wheeler-Kingshott, C. A. M., Boulby, P. A., Scaravilli, F., Altmann, D. R., Barker, G. J., Tofts, P. S., & Miller, D. H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.010 · Cited by 395
Self-citation
Metadata
- Authors
- Schmierer, K., Scaravilli, F., Barker, G. J., Gordon, R., MacManus, D. G., & Miller, D. H.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Miller, D. H.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2003-11-03
- Volume
- 29
- Issue
- 6
- Pages
- 596-601
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W1999360135
- Cited by
- 35
- References
- 0
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Multiple Sclerosis Society
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- multiple sclerosis, stereotactic navigation, postmortem brain, T2-weighted MRI, FLAIR, lesion detection, hyperintensity, white matter lesions
- MeSH terms
- Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Postmortem Changes, Radiography, Sensitivity and Specificity, Stereotaxic Techniques, Tissue Fixation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
