The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Herb–drug interactions: Review and assessment of report reliability
Open accessAbstract
Aims The aim of this systematic review was to assess the published clinical evidence on interactions between herbal and conventional drugs. Methods Four electronic databases were searched for case reports, case series or clinical trials of such interactions. The data were extracted and validated using a scoring system for interaction probability. Results One hundred and eight cases of suspected interactions were found. 68.5% were classified as ‘unable to be evaluated’, 13% as ‘well‐documented’ and 18.5% as ‘possible’ interactions. Warfarin was the most common drug (18 cases) and St John's wort the most common herb (54 cases) involved. Conclusion Herb–drug interactions undoubtedly do occur and may put individuals at risk. However our present knowledge is incomplete and more research is urgently needed.
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Fugh-Berman, A. (2000) · The Lancet · doi:10.1016/s0140-6736(99)06457-0 · Cited by 1,099
Self-citationMedical Toxicology: Diagnosis and Treatment of Human Poisoning.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-502_9 · Cited by 948
(2006) · Pharmacodynamic Basis of Herbal Medicine, Second Edition · doi:10.1201/9781420006452.ch4 · Cited by 905
Indinavir concentrations and St John's wort
Piscitelli, S. C., Burstein, A. H., Chaitt, D., Alfaro, R. M., & Falloon, J. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05712-8 · Cited by 874
Herbal Medicines: A Guide for Healthcare Professionals
Newall, C. A., Anderson, L. A., & Phillipson, J. D. (1996) · Medical Entomology and Zoology · Cited by 842
Miller, L. G. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.20.2200 · Cited by 809
Acute heart transplant rejection due to Saint John's wort
Ruschitzka, F., Meier, P. J., Turina, M., Lüscher, T. F., & Noll, G. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05467-7 · Cited by 644
JOHNE, A. (1999) · Clinical Pharmacology & Therapeutics · doi:10.1053/cp.1999.v66.a101944 · Cited by 586
St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4
Dürr, D. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.112240 · Cited by 584
Interactions of Warfarin with Drugs and Food
Wells, P. S., Holbrook, A. M., Crowther, N. R., & Hirsh, J. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-9-199411010-00009 · Cited by 536
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Interactions Between Herbal Medicines and Prescribed Drugs: An Updated Systematic Review
Izzo, A. A., & Ernst, E. (2009) · Drugs · doi:10.2165/11317010-000000000-00000 · Cited by 801
Self-citationBorrelli, F., & Izzo, A. A. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9146-8 · Cited by 288
Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes
Wang, H., & LeCluyse, E. L. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342150-00003 · Cited by 278
Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review
Nazari, S., Rameshrad, M., & Hosseinzadeh, H. (2017) · Phytotherapy Research · doi:10.1002/ptr.5893 · Cited by 266
Herbal bioactivation: The good, the bad and the ugly
Zhou, S., Koh, H.-L., Gao, Y., Gong, Z.-Y., & Lee, E. J. D. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.09.035 · Cited by 256
Metadata
- Authors
- Fugh‐Berman, A., & Ernst, E.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2001-11
- Volume
- 52
- Issue
- 5
- Pages
- 587-595
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W2124288520
- Cited by
- 364
- References
- 57
- FWCI
- 39.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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