The presence of a common mitochondrial DNA variant is associated with fasting insulin levels in Europeans in Auckland
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In European and Asian groups, the 16189T>C variant in the mtDNA D-loop is linked to obesity and type 2 diabetes.
“Analysis of both European126 and Asian populations127 showed that the 16189T>C substitution in the D-loop region of mtDNA is associated with obesity and T2DM.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [126]
Variations in mtDNA have been linked to higher risk for metabolic disorders.
“Interestingly, mtDNA polymorphisms have been associated with an increased risk of metabolic diseases.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [126]
Cites
van den Ouweland, J. M. W., Lemkes, H. H. P. J., Ruitenbeek, W., Sandkuijl, L. A., de Vijlder, M. F., Struyvenberg, P. A. A., van de Kamp, J. J. P., & Maassen, J. A. (1992) · Nature Genetics · doi:10.1038/ng0892-368 · Cited by 1,127 · see citing works
Phylogeography of mitochondrial DNA in western Europe
Richards, M. B., Macaulay, V. A., Bandelt, H. J., & Sykes, B. C. (1998) · Annals of Human Genetics · doi:10.1046/j.1469-1809.1998.6230241.x · Cited by 419 · see citing works
Self-citation(1995) · Europe PMC (PubMed Central) · Cited by 226 · see citing works
Poulton, J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.13.1581 · Cited by 218 · see citing works
Self-citationA common mitochondrial DNA variant is associated with insulin resistance in adult life
Poulton, J., Brown, M. S., Cooper, A., Marchington, D. R., & Phillips, D. I. W. (1998) · Diabetologia · doi:10.1007/s001250050866 · Cited by 160 · see citing works
Self-citationMitochondrial 16189 variant, thinness at birth, and type-2 diabetes
Dunger, D. B., Casteels, K., Ong, K. K., Phillips, D. I., Bendall, H., Pembrey, M. E., & Poulton, J. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05817-6 · Cited by 106 · see citing works
Self-citationKhogali, S., Mayosi, B. M., Beattie, J. M., McKenna, W. J., Watkins, H. C., & Poulton, J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04422-6 · Cited by 104 · see citing works
Self-citationMitochondrial DNA, diabetes and pancreatic pathology in Kearns-Sayre syndrome
Poulton, J., O'Rahilly, S., Morten, K., et al. (1995) · Diabetologia · doi:10.1007/s001250050366 · Cited by 70 · see citing works
Self-citationPolynesians: prone to obesity and Type 2 diabetes mellitus but not hyperinsulinaemia
Simmons, D. S., Thompson, C. F., & Volklander, D. (2001) · Diabetic Medicine · doi:10.1046/j.1464-5491.2001.00435.x · Cited by 69 · see citing works
Self-citationMitochondrial gene mutations and diabetes mellitus
Sue, C. M., Holmes-Walker, D. J., Morris, J. G., et al. (1993) · The Lancet · doi:10.1016/0140-6736(93)93032-v · Cited by 47 · see citing works
Poulton, J. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01529-7 · Cited by 43 · see citing works
Self-citationInsulin resistance associated with maternally inherited diabetes and deafness
Gebhart, S. S. P., Shoffner, J. M., Koontz, D. A., Kaufman, A. E., & Wallace, D. C. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90231-0 · Cited by 40 · see citing works
Mechanistn. of insulin secretion
Ashcroft, F. M., & Ashcroft, S. J. H. (1992) · doi:10.1093/oso/9780199632299.003.0004 · Cited by 29 · see citing works
Late-replicating satellites: something for all centromeres?
Schubert, I. A. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01570-4 · Cited by 12 · see citing works
Critical appraisal of published research evidence: treatment of gestational diabetes
Dornan, T., & Hollis, S. (2001) · Diabetic Medicine · doi:10.1046/j.1464-5491.2001.00001-2.x · Cited by 9 · see citing works
A common mtDNA variant may be a susceptibility factor in 3 multifactorial diseases.
Poulton, J., Macaulay, V. A., Livesey, K., et al. (2001) · The American Journal of Human Genetics · Cited by 2 · see citing works
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Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
Benton, M., Macartney-Coxson, D., Eccles, D., Griffiths, L., Chambers, G., & Lea, R. (2012) · PLoS ONE · doi:10.1371/annotation/08aca5be-f760-4595-8562-faf009899c46 · Cited by 13 · see citing works
- Authors
- Poulton, J., Bednarz, A. L., Scott‐Brown, M., Thompson, C., Macaulay, V. A., & Simmons, D.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2002-11
- Volume
- 19
- Issue
- 11
- Pages
- 969-971
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2053604560
- Cited by
- 27
- References
- 16
- Citations by year
- 2022: 1 · 2020: 2 · 2018: 1 · 2015: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- mitochondrial DNA, fasting insulin, insulin levels, type 2 diabetes risk, genetic association, Europeans, Auckland
- MeSH terms
- Adult, Aged, Blood Glucose, Diabetes Mellitus, Type 2, DNA, Mitochondrial, Europe, Fasting, Female, Humans, Insulin, Male, Middle Aged, New Zealand, Glucose Intolerance
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