The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease
Abstract
The purpose of this investigation was to use molecular and immunological techniques to determine whether oral Treponema infected the human brain. Pieces of frontal lobe cortex from 34 subjects were analyzed with species‐specific PCR and monoclonal antibodies. PCR detected Treponema in 14/16 Alzheimer's disease (AD) and 4/18 non‐AD donors (P < 0.001), and AD specimens had more Treponema species than controls (P < 0.001). PCR also detected Treponema in trigeminal ganglia from three AD and two control donors. Cortex from 15/16 AD subjects and 6/18 controls contained Treponema pectinovorum and/or Treponema socranskii species‐specific antigens (P < 0.01). T. pectinovorum and/or T. socranskii antigens were also found in trigeminal ganglia and pons from four embalmed cadavers, and 2/4 cadavers also had Treponema in the hippocampus. These findings suggest that oral Treponema may infect the brain via branches of the trigeminal nerve.
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Cites
Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain
Balin, B. J., Gérard, H. C., Arking, E. J., Appelt, D. M., Branigan, P. J., Abrams, J. T., Whittum-Hudson, J. A., & Hudson, A. P. (1998) · Medical Microbiology and Immunology · doi:10.1007/s004300050071 · Cited by 506
Failure To Detect Chlamydia pneumoniae in the Late-Onset Alzheimer's Brain
Ring, R. H., & Lyons, J. M. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.7.2591-2594.2000 · Cited by 81
Cited by
Oral microbiomes: more and more importance in oral cavity and whole body
Gao, L., Xu, T., Huang, G., Jiang, S., Gu, Y., & Chen, F. (2018) · Protein & Cell · doi:10.1007/s13238-018-0548-1 · Cited by 770
Fan, X., Alekseyenko, A. V., Wu, J., Peters, B. A., Jacobs, E. J., Gapstur, S. M., Purdue, M. P., Abnet, C. C., Stolzenberg-Solomon, R., Miller, G., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312580 · Cited by 702
The Infectious Etiology of Alzheimer’s Disease
Sochocka, M., Zwolińska, K., & Leszek, J. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170313122937 · Cited by 399
Ilievski, V., Zuchowska, P. K., Green, S. J., Toth, P. T., Ragozzino, M. E., Le, K., Aljewari, H. W., O’Brien-Simpson, N. M., Reynolds, E. C., & Watanabe, K. (2018) · PLOS ONE · doi:10.1371/journal.pone.0204941 · Cited by 372
Miklossy, J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-90 · Cited by 355
Metadata
- Authors
- Riviere, G. R., Riviere, K. H., & Smith, K. S.
- Venue
- Oral Microbiology and Immunology
- Publisher
- Wiley
- Published
- 2002-03-19
- Volume
- 17
- Issue
- 2
- Pages
- 113-118
- ISSN
- 0902-0055 (ISSN-L)
- 1399-302X
- OpenAlex
- W1992031722
- Cited by
- 362
- References
- 2
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Riviere, G. R., Riviere, K. H., & Smith, K. S. (2002). Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease. Oral Microbiology and Immunology. https://doi.org/10.1046/j.0902-0055.2001.00100.x
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